RNA interference suppression of neurodegenerative diseases and methods of use thereof
First Claim
Patent Images
1. An isolated RNA duplex comprising a first strand of RNA and a second strand of RNA, wherein the first strand comprises at least 15 contiguous nucleotides encoded by shSCA1.F10 (SEQ ID NO:
- 102), SEQ ID NO;
59, SEQ ID NO;
68, SEQ ID NO;
72, SEQ ID NO;
74, SEQ ID NO;
78, SEQ ID NO;
82, SEQ ID NO;
84, or SEQ ID NO;
88, SEQ ID NO;
106, SEQ ID NO;
107, SEQ ID NO;
110, SEQ ID NO;
112, SEQ ID NO;
113, SEQ ID NO;
115, SEQ ID NO;
117, SEQ ID NO;
119, SEQ ID NO;
122, SEQ ID NO;
124, SEQ ID NO;
125, SEQ ID NO;
126, SEQ ID NO;
127, SEQ ID NO;
129, SEQ ID NO;
131, SEQ ID NO;
132, SEQ ID NO;
134, SEQ ID NO;
138, or SEQ ID NO;
142, and wherein the second strand is complementary to at least 12 contiguous nucleotides of the first strand.
3 Assignments
0 Petitions
Accused Products
Abstract
The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.
96 Citations
22 Claims
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1. An isolated RNA duplex comprising a first strand of RNA and a second strand of RNA, wherein the first strand comprises at least 15 contiguous nucleotides encoded by shSCA1.F10 (SEQ ID NO:
- 102), SEQ ID NO;
59, SEQ ID NO;
68, SEQ ID NO;
72, SEQ ID NO;
74, SEQ ID NO;
78, SEQ ID NO;
82, SEQ ID NO;
84, or SEQ ID NO;
88, SEQ ID NO;
106, SEQ ID NO;
107, SEQ ID NO;
110, SEQ ID NO;
112, SEQ ID NO;
113, SEQ ID NO;
115, SEQ ID NO;
117, SEQ ID NO;
119, SEQ ID NO;
122, SEQ ID NO;
124, SEQ ID NO;
125, SEQ ID NO;
126, SEQ ID NO;
127, SEQ ID NO;
129, SEQ ID NO;
131, SEQ ID NO;
132, SEQ ID NO;
134, SEQ ID NO;
138, or SEQ ID NO;
142, and wherein the second strand is complementary to at least 12 contiguous nucleotides of the first strand. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
- 102), SEQ ID NO;
Specification