Device and method for particle therapy verification

• US 8,481,951 B2
• Filed: 07/03/2009
• Issued: 07/09/2013
• Est. Priority Date: 07/03/2008
• Status: Active Grant

• Current Assignee: Ion Beam Applications s.a.
• Original Assignee: Ion Beam Applications s.a.
• Inventors: Jongen, Yves, Stichelbaut, Frdric
• Primary Examiner(s): Sung, Christine
• Application Number:
  US13/002,484
• Publication Number:
  US 20110186720A1
• Time in Patent Office: 1,467 Days
• Field of Search: 250/363.1, 250/363.05, 250/363.08
• US Class Current: 250/363.1
• CPC Class Codes: A61B 6/4258 for detecting non x-ray radiation, e.g. gamma radiation A61B6/037 takes precedence
• CPC Class Codes: A61N 2005/1052 using positron emission tomography [PET] single photon emission computer tomography [SPECT] imaging
• CPC Class Codes: A61N 2005/1087 Ions; Protons
• CPC Class Codes: A61N 5/1048 Monitoring, verifying, controlling systems and methods
• CPC Class Codes: G01T 1/1642 using a scintillation crystal and position sensing photodetector arrays, e.g. ANGER cameras
• CPC Class Codes: G01T 1/169 Exploration, location of contaminated surface areas

Abstract

The invention is related to the field of charged Hadron Therapy, i.e. radiation therapy using strongly interacting particles. More particularly, the invention relates to a detector and method for measuring the beam range of a charged hadron beam in a target object as well as the particle dose distribution in the target object.

Claims

1. A device for charged hadron therapy verification by detecting and/or quantifying prompt gammas produced when irradiating an object or a body with a charged hadron beam, said device comprising a gamma-ray pin-hole camera arranged to acquire a number of said prompt gammas emitted while the charged hadron beam is penetrating the object or body, wherein the pinhole camera comprises at least one scintillating crystal optically coupled to a plurality of photomultiplier tubes which form a linear or two-dimensional array, and wherein said pin-hole camera comprises a pinhole collimator made of a high atomic number material and having a conically shaped hole enabling detection of prompt gammas that are not emitted from 90°

of the beam direction.

2. The device according to claim 1, wherein said gamma-ray pinhole camera further comprises additional shielding means to avoid detection of unwanted particles.

3. The device according to claim 1, wherein said gamma-ray pin-hole camera comprises electronic means for data acquisition.

4. The device according to claim 3, further comprising computing means connected to said electronic means to enable determination from the counted said prompt gammas, of a measured penetration depth or range of said charged hadron beam in said object or body.

5. The device according to claim 4, wherein said computing means enables comparison of the measured penetration depth with the theoretical or planned penetration depth.

6. The device according to claim 4, wherein said computing means connected to said electronic means enables building an image representing a relative dose deposition.

7. The device according to claim 6, wherein said image is a two-dimensional or three-dimensional representation of the relative dose deposition.

8. The device according to claim 1, wherein an optical axis of the camera is perpendicular to the direction of the beam.

9. The device according to claim 1, wherein an inner diameter of the pinhole is strictly superior to a value of a wavelength of emitted prompt gammas which are most energetic.

10. The device according to claim 1 further comprising electronic means to acquire the number of said prompt gammas in synchrony with a time structure of said charged hadron beam.

11. A method for charged hadron therapy verification by detecting prompt gammas obtained by irradiating a phantom with a particle beam comprising the steps of:

positioning a prompt gamma detector in a fixed position relatively to the phantom;

irradiating the phantom with a charged hadron beam;

detecting emitted prompt gammas during irradiation;

deducing from the detected prompt gammas a range or penetration depth of the charged hadron beam;

measuring the range of the charged hadron beam in the phantom with a dedicated range measuring device;

comparing the deduced range based on the prompt gamma detection with the range measured with the dedicated range measuring device,

wherein the prompt gamma detector is a gamma-ray pin-hole camera comprising at least one scintillating crystal optically coupled to a plurality of photomultiplier tubes which form a linear or two-dimensional array, and wherein said pin-hole camera comprises a pinhole collimator made of a high atomic number material and having a conically shaped hole, enabling to detect prompt gammas that are not emitted from 90°

of the beam direction.

12. The method according to claim 11 further comprising the step of calculating a radiation dose given to a phantom based on the detected prompt gammas.

13. A device for charged hadron therapy verification by detecting and/or quantifying prompt gammas produced when irradiating an object or a body with a charged hadron beam, said device comprising a gamma-ray pin-hole camera arranged to acquire a number of said prompt gammas emitted while the charged hadron beam is penetrating the object or body, and wherein said pin-hole camera comprises a pinhole collimator made in a high atomic number material and having a conically shaped hole which enables detection of prompt gammas that are not emitted from 90°

of the beam direction.

14. A device used in combination with charged hadron therapy, which therapy uses a charged hadron beam, the device configured and arranged to detect prompt gammas produced when irradiating and penetrating an object with the charged hadron beam, the device comprising:

a pinhole camera arranged and configured in the device to detect the prompt gammas emitted when the charged hadron beam penetrates the object, the pinhole camera including;

a shielding housing; and

at least one scintillating crystal in the shielding housing;

at least one photomultiplier tube optically coupled to the at least one scintillating crystal in the shielding housing,

the shielding housing having an access hole through the shielding housing, the access hole having side walls which define a hole cross section which angles inward as the hole extends from outside to inside the housing, the pinhole camera configured and arranged in the device such that the pinhole camera is effective to detect prompt gammas that are not emitted 90°

from the hadron beam direction.

15. The device according to claim 14, wherein the shielding housing is effective to avoid detection of unwanted particles.

16. The device according to claim 15, wherein the device further comprises an electronic device which is effective for data acquisition.

17. The device according to claim 16, further comprising a computer connected to the electronic device, the computer in combination with the electronic device effective for determining from counted prompt gammas a measured penetration depth or range of the charged hadron beam in the object or body.

18. The device according to claim 17, wherein the computer is effective to compare a measured penetration depth with a theoretical or planned penetration depth.

19. The device according to claim 17, wherein the computer connected to the electronic device is effective to build an image representing a relative dose deposition.

20. The device according to claim 19, wherein the image is a two-dimensional or three-dimensional representation of the relative dose deposition.

21. The device according to claim 14, wherein an optical axis of the camera is perpendicular to the direction of the beam.

22. The device according to claim 14, wherein an inner diameter of the pinhole is strictly superior to a value of a wavelength of emitted prompt gammas which are most energetic.

23. The device according to claim 14 further comprising an electronic device which is effective to acquire a number of prompt gammas in synchrony with a time structure of the charged hadron beam.

24. A device for use in charged hadron therapy verification by detecting and/or quantifying prompt gammas produced when irradiating and penetrating an object or a body with a charged hadron beam, the device comprising:

a gamma-ray pin-hole camera arranged to acquire a number of the prompt gammas emitted while the charged hadron beam is penetrating the object or body; and

a shielding housing, the shielding housing having an access hole through the shielding housing, the access hole having side walls which define a hole cross section which angles inward as the hole extends from outside to inside the housing, the pinhole camera configured and arranged in the device such that the pinhole camera is effective to detect prompt gammas that are not emitted 90°

from the hadron beam direction.

25. The device according to claim 24, wherein the device further comprises an electronic device which is effective for data acquisition.

26. The device according to claim 25, further comprising a computer connected to the electronic device, the computer in combination with the electronic device effective for determining from counted prompt gammas a measured penetration depth or range of the charged hadron beam in the object or body.

27. The device according to claim 26, wherein the computer is effective to compare a measured penetration depth with a theoretical or planned penetration depth.

28. The device according to claim 27, wherein the computer connected to the electronic device is effective to build an image representing a relative dose deposition.

29. The device according to claim 28, wherein the image is a two-dimensional or three-dimensional representation of the relative dose deposition.

30. The device according to claim 24, wherein an optical axis of the camera is perpendicular to the direction of the beam.

31. The device according to claim 24, wherein an inner diameter of the pinhole is strictly superior to a value of a wavelength of emitted prompt gammas which are most energetic.

32. The device according to claim 24 further comprising an electronic device which is effective to acquire a number of prompt gammas in synchrony with a time structure of the charged hadron beam.