Handheld reflectometer for measuring macular pigment

• US 8,485,664 B2
• Filed: 10/13/2011
• Issued: 07/16/2013
• Est. Priority Date: 10/13/2010
• Status: Active Grant

• Current Assignee: Ocular Prognostics, LLC
• Original Assignee: Ocular Prognostics, LLC
• Inventors: Rowe, T. Scott
• Primary Examiner(s): HASAN, MOHAMMED A
• Application Number:
  US13/273,050
• Publication Number:
  US 20120092619A1
• Time in Patent Office: 642 Days
• Field of Search: 351200-246
• US Class Current: 351/221
• CPC Class Codes: A61B 3/0016 Operational features thereof
• CPC Class Codes: A61B 3/12 for looking at the eye fundus, e.g. ophthalmoscopes A61B3/13 takes precedence
• CPC Class Codes: A61B 3/1241 specially adapted for observation of ocular blood flow, e.g. by fluorescein angiography
• CPC Class Codes: A61B 3/152 for aligning

Abstract

A macular pigment reflectometer is handheld, light, and portable. It can be provided as a part of a self-contained system. The self-contained system includes a docking station in which the macular pigment reflectometer is placed between uses. The docking station is used to recharge the battery of the handheld macular pigment reflectometer. The docking station also has one or more types of communication ports, such as one for a wired or wireless internet connection, through which the handheld macular pigment reflectometer can communicate with a computer or an electronic medical records system. The instrument operates in a pulsed operating mode wherein relative instrument-to-eye motion is reduced and, preferably, nearly eliminated. The handheld macular pigment reflectometer contains an on-board spectrometer which is designed to capture spectra in very short intervals of time. A trigger on the instrument allows for a rapid, intuitive, and sequential alignment followed by rapid data gathering.

Claims

1. A reflectometry instrument to measure macular pigment of a macula of a human eye, comprising:

a housing including a lower hand-held portion;

an assembly of optical elements arranged within the housing to sequentially image the eye with multiple fields of view and to illuminate the eye with multiple light sources;

an actuatable trigger having a first trigger switch position, a second trigger switch position and a third trigger switch position;

a spectrally-modifiable light source for emitting an illumination beam in a direction toward the macula, the spectrally-modifiable light source providing a range of spectra depending on the position of the actuatable trigger; and

a spectrometer for measuring one or more spectra measurements of a detection beam, the detection beam being reflected from the macula, each of the one or more spectra measurements being indicative of the amount of the macular pigment in the macula, and combining the one or more spectra measurements to result in a macular pigment optical density measurement.

2. The reflectometry instrument according to claim 1, wherein the macular pigment optical density measurement includes lutein and zeaxanthin optical densities.

3. The reflectometry instrument according to claim 1, wherein combining the one or more spectra includes statistical averaging and filtering.

4. The reflectometry instrument according to claim 1, wherein the first trigger switch position corresponds to spectra in the range of 680-900 nm.

5. The reflectometry instrument according to claim 1, wherein the second trigger switch position corresponds to spectra in the range of 630-880 nm.

6. The reflectometry instrument according to claim 1, wherein the third trigger switch position corresponds to spectra in the range of 400-880 nm.

7. A hand-held reflectometry instrument to measure macular pigment of a macula of a human eye, comprising:

a housing including an actuatable trigger having a first switch position, a second switch position and a third switch position;

a first light source within the housing for emitting an illumination beam in a direction toward the macula; and

a spectrometer within the housing for measuring a detection beam, the detection beam being a portion of the illumination beam reflected from the macula, the detection beam being indicative of the amount of the macular pigment in the macula.

8. The hand-held reflectometry instrument of claim 7, wherein a hand-held portion is graspable by an operator for assisting in manual alignment of the illumination beam with the macula.

9. The hand-held reflectometry instrument of claim 7, further comprising a light source engine, wherein in the first switch position, the actuatable trigger permits alignment of the instrument relative to an anterior portion of the eye, and in the second switch position, the actuatable trigger causes the operation of the light source engine and facilitates alignment to a posterior portion of the eye.

10. The hand-held reflectometry instrument of claim 7, further comprising a second light source for aligning the instrument, and wherein in the first switch position, the actuatable trigger activates the first light source for assisting in aligning the instrument to the eye, and in the second switch position, the actuatable trigger activates the second light source for completion of the alignment of the eye, and wherein the second light source includes a different spectral composition than the first light source.

11. The hand-held reflectometry instrument of claim 10, wherein in the third switch position, the actuatable trigger activates a measurement function of the instrument for providing that all returning light is directed down a posterior optical path to the spectrometer.

12. The hand-held reflectometry instrument of claim 7, further comprising a display on the housing that provides at least one of (i) an image of an output corresponding to the amount of the macular pigment in the macula, and (ii) an image of the eye for alignment or measurement purposes.

13. The hand-held reflectometry instrument of claim 7, further comprising a first port, the first port being connectable to a second port of a docking station for receiving the hand-held reflectometry instrument.

14. The hand-held reflectometry instrument of claim 13, wherein the first port and the second port are connectable when the instrument is docked on the docking station, the first port and the second port transmitting power to a rechargeable battery within the instrument.

15. The hand-held reflectometry instrument of claim 13, wherein the first port and the second port are connectable when the instrument is docked on the docking station, the first port and the second port transmitting data regarding the macular pigment measured by the instrument.

16. The hand-held reflectometry instrument of claim 13, wherein at least one of the instrument and docking station includes a port for communicating macular pigment data measured by the instrument to a medical data system.

17. The hand-held reflectometry instrument of claim 13, wherein at least one of the instrument and docking station includes a port for communicating macular pigment data measured by the instrument to a computer.

18. The hand-held reflectometry instrument of claim 7, wherein the instrument measures the relative amounts of zeaxanthin and lutein in the macular pigment.

19. A method of determining an amount of macular pigment in the macula of a human eye, comprising:

using a multi-step alignment process involving (i) a first light source to provide an alignment relative to a patient'"'"'s pupil, and (ii) a second light source to provide alignment relative to the patient'"'"'s retina after alignment relative to the patient'"'"'s pupil;

after the alignment process, (iii) activating a measurement process by passing an illumination beam through a lens system and onto the macula;

receiving, with a spectrometer, a detection beam reflected from the macula; and

measuring characteristics of the detection beam at the spectrometer.

20. The method of claim 19, wherein the multi-step alignment process includes receiving multiple signals from a switch associated with a trigger on a handheld instrument, a first one of the trigger signals activating the first light source, a second one of the trigger signals activating the second light source, and a third one of the trigger signals activating the measurement process.

21. The method of claim 20, wherein the third one of the trigger signals activates the illumination beam for passing the illumination beam through the lens system and onto the macula and back to the spectrometer for multiple measurements, the multiple measurements being combined, through statistical averaging and filtering, to result in a macular pigment optical density measurement, including lutein and zeaxanthin optical densities.

22. The method of claim 19, wherein additional characteristics of the eye may be determined using the multi-step alignment process, including melanin density and lens optical density.