Devices and methods for controlling expandable prostheses during deployment

• US 8,486,132 B2
• Filed: 03/22/2007
• Issued: 07/16/2013
• Est. Priority Date: 03/22/2007
• Status: Active Grant

• Current Assignee: JW Medical Systems Ltd
• Original Assignee: JW Medical Systems Ltd
• Inventors: Snow, David W., Demarais, Denise, Lin, Stuart
• Primary Examiner(s): Jackson, Gary
• Assistant Examiner(s): EVERAGE, KEVIN D
• Application Number:
  US11/689,927
• Publication Number:
  US 20080234795A1
• Time in Patent Office: 2,308 Days
• Field of Search: 623/6.12, 623/6.16
• US Class Current: 623/1.16
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2/915 with bands having a meander structure, adjacent bands being connected to each other
• CPC Class Codes: A61F 2/95 Instruments specially adapted for placement or removal of stents or stent-grafts
• CPC Class Codes: A61F 2/9517 handle assemblies therefor
• CPC Class Codes: A61F 2/966 with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod
• CPC Class Codes: A61F 2002/826 more than one stent being applied sequentially
• CPC Class Codes: A61F 2002/91541 Adjacent bands are arranged out of phase
• CPC Class Codes: A61F 2002/91558 connected peak to peak
• CPC Class Codes: A61F 2002/91591 Locking connectors, e.g. using male-female connections

Abstract

A catheter for delivering a prosthesis to a treatment site in a body lumen comprises an elongate flexible member and a sheath slidably disposed thereover. A plurality of self-expanding tubular prostheses are carried in axially spaced apart locations along the elongate member, within the sheath. The prostheses may be selectively interlocked with one another and are constrained by the sheath in a radially contracted configuration. The prostheses are separately releasable from the sheath when the sheath is retracted relative to the elongate member. The catheter also has a pusher member slidably disposed along the elongate member within the sheath. The pusher is adapted to move past the prostheses in a first direction without displacing the prostheses, while in a second direction the pusher engages a selected prosthesis so as to move the prosthesis with the pusher to interlock the selected prosthesis with a second prosthesis.

Claims

1. A method for delivering a prosthesis to a body lumen, the method comprising:

introducing into the body lumen one or more self-expanding tubular prostheses carried at axially spaced apart locations along an elongate flexible member, the self-expanding tubular prostheses being axially separated and unlocked within a sheath and constrained in a contracted configuration within the sheath, the body lumen having a lesion with a lesion length;

selecting a first group of the self-expanding tubular prostheses for delivery by proximally retracting a pusher member disposed proximal of the first group of prostheses, the first group of prostheses having a combined length that substantially traverses the lesion length;

distally advancing the pusher member to axially translate the selected first group of prostheses within the sheath to bring the first group of prostheses into locking engagement with each other within the sheath; and

uncovering the first group of prostheses from the sheath so that they are unconstrained from expansion, wherein the first group expands at the first treatment site.

2. The method of claim 1, wherein the first group expands at the first treatment site while at least a second group of prostheses is retained within the sheath.

3. The method of claim 1, further comprising:

selecting one or more additional self-expanding tubular prostheses; and

bringing the additional self-expanding tubular prostheses into engagement with the first group within the sheath so that the additional prostheses interlock with the first group.

4. The method of claim 1, wherein the pusher member has a flexible engagement member that is deflected by the prostheses as the pusher member is retracted proximally.

5. The method of claim 4, wherein the flexible engagement member comprises a plurality of resilient fingers.

6. The method of claim 5, wherein each of the plurality of resilient fingers extend radially away from the pusher member, and wherein one or more of the plurality of resilient fingers engages a proximal-most prosthesis of the first group when advanced distally to bring the first group into engagement with each other.

7. The method of claim 1, wherein axially translating the at least one prosthesis comprises engaging the prosthesis with a flexible engagement member disposed on the pusher member.

8. The method of claim 1, further comprising stopping the first group of prostheses from moving distally with a stopping element disposed on the elongate flexible member.

9. The method of claim 1, wherein uncovering the first group comprises proximally retracting the sheath.

10. The method of claim 1, further comprising releasing a therapeutic agent from the first group after expansion at the treatment site.

11. The method of claim 10, wherein the therapeutic agent comprises an anti-restenosis agent.

12. The method of claim 1, wherein the plurality of self-expanding tubular prostheses have a length in the range of about 5 mm to about 50 mm.

13. The method of claim 1, wherein each of the plurality of self-expanding tubular prostheses has the same length.

14. The method of claim 1, wherein at least one of the plurality of self-expanding tubular prostheses has a different length than at least another of the prostheses.

15. The method of claim 1, wherein the prosthesis comprises a plurality of substantially parallel columns of open cells, the columns spaced apart and formed from a zig-zag pattern of substantially axial struts joined together with a connector.

16. The method of claim 15, wherein the connector comprises a U-shaped portion.

17. The method of claim 15, wherein the open cells in a first column are out of phase with the open cells in an adjacent column.

18. The method of claim 1, wherein a plurality of bridges join the columns of open cells together.

19. The method of claim 18, wherein the bridges are sigmoidally shaped.

20. The method of claim 1, wherein a prosthesis comprises an interlocking tab disposed on a first end of the prosthesis and adapted to interlock with an adjacent prosthesis.

21. The method of claim 20, wherein the prosthesis comprises a mating tab disposed on a second end of the prosthesis opposite the first end, the mating tab adapted to interlock with an interlocking tab on an adjacent prosthesis.

22. The method of claim 20, wherein the interlocking tab comprises one or more struts defining an aperture therein.

23. The method of claim 20, wherein the interlocking tab comprises a radiopaque marker.

24. The method of claim 1, wherein the interlocked prostheses prevent the prostheses from jumping away from the elongate flexible member when the first group is unconstrained.

25. The method of claim 1, wherein each of the prostheses comprises a distal U-shaped interlocking member and a proximal U-shaped interlocking member, and wherein the first group of prostheses are interlocked by mating distal U-shaped interlocking members and proximal U-shaped interlocking members of adjacent prostheses.

26. The method of claim 1, wherein the elongate flexible member comprises a radiopaque marker at a distal end of the elongate flexible member, and wherein the pusher member disposed within the elongate flexible member comprises a radiopaque marker at a distal end of the pusher member, the method further comprising:

retracting the pusher member proximally to select the first group of prostheses; and

bringing the first group of prostheses into engagement with each other by advancing the pusher member distally, wherein the radiopaque marker at the distal end of the elongate flexible member and the radiopaque marker at the distal end of the pusher member facilitate in selecting the first group of prostheses so that the combined length of the first group substantially traverses the lesion length.