Anti-obesity devices

• US 8,486,153 B2
• Filed: 12/08/2006
• Issued: 07/16/2013
• Est. Priority Date: 12/02/2002
• Status: Active Grant

• Current Assignee: GI Dynamics Incorporated
• Original Assignee: GI Dynamics Incorporated
• Inventors: Levine, Andy H., Melanson, David A., Meade, John C.
• Primary Examiner(s): Lucchesi, Nicholas
• Assistant Examiner(s): PATEL, PRITESH ASHOK
• Application Number:
  US11/635,890
• Publication Number:
  US 20070083271A1
• Time in Patent Office: 2,412 Days
• Field of Search: 424/443, 604/502, 623/23.65, 623/23.64
• US Class Current: 623/23.65
• CPC Class Codes: A61B 17/0401 Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors A61B17/0642 takes precedence; fixation devices for tendons or ligaments A61F2/0811
• CPC Class Codes: A61B 17/0469 Suturing instruments for use in minimally invasive surgery, e.g. endoscopic surgery
• CPC Class Codes: A61B 17/0482 Needle or suture guides guides for drills, pins or wire A61B17/17; for puncturing needles A61B17/3403
• CPC Class Codes: A61B 17/1114 of the digestive tract, e.g. bowels or oesophagus
• CPC Class Codes: A61B 2017/00238 Type of minimally invasive operation A61B2017/00805 takes precedence
• CPC Class Codes: A61B 2017/00867 shape memory effect for prostheses A61F2210/0014
• CPC Class Codes: A61B 2017/0419 H-fasteners
• CPC Class Codes: A61B 2017/061 hollow or tubular suture extending inside a hollow needle A61B2017/06052; hollow sutures A61B2017/06185
• CPC Class Codes: A61F 2/04 Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts A61F2/18, A61F2/20 take precedence; devices, other than stent-grafts, providing patency to, or preventing collapsing of, tubular structures of the body other than stent-grafts, e.g. stents A61F2/82; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95
• CPC Class Codes: A61F 2/07 Stent-grafts
• CPC Class Codes: A61F 2/848 having means for fixation to the vessel wall, e.g. barbs
• CPC Class Codes: A61F 2/90 characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2/95 Instruments specially adapted for placement or removal of stents or stent-grafts
• CPC Class Codes: A61F 2002/044 Oesophagi or esophagi or gullets
• CPC Class Codes: A61F 2002/045 Stomach, intestines
• CPC Class Codes: A61F 2002/075 the stent being loosely attached to the graft material, e.g. by stitching
• CPC Class Codes: A61F 2002/8483 Barbs
• CPC Class Codes: A61F 2002/8486 provided on at least one of the ends
• CPC Class Codes: A61F 2002/9528 for retrieval of stents
• CPC Class Codes: A61F 2220/0016 with sharp anchoring protrusions, e.g. barbs, pins, spikes
• CPC Class Codes: A61F 2250/0039 : differing in diameter
• CPC Class Codes: A61F 5/0076 : preventing normal digestion, e.g. Bariatric or gastric sleeves
• CPC Class Codes: A61F 5/0089 : Instruments for placement or removal

Abstract

Method and apparatus for limiting absorption of food products in specific parts of the digestive system is presented. A gastrointestinal implant device is anchored in the pyloric portion of the gastrointestinal system and extends beyond the ligament of Treitz. All food exiting the stomach is funneled through the device. The gastrointestinal device includes an anchor for anchoring the device in the pyloric portion and a flexible sleeve that extents into the duodenum. The anchor is collapsible for endoscopic delivery and removal.

Claims

1. A gastrointestinal implant device comprising:

a flexible sleeve, open at both ends and configured to extend into the intestine and to receive chyme from the stomach, the flexible sleeve within the intestine being impregnated with a drug, the drug being peptide-YY; and

a collapsible anchor coupled to a proximal end of the sleeve to anchor the proximal portion of the sleeve at the proximal end of the intestine.

2. A gastrointestinal implant device comprising:

a flexible sleeve, open at both ends and configured to extend into the intestine and to receive chyme from the stomach, the flexible sleeve within the intestine being impregnated with a drug; and

a collapsible anchor coupled to a proximal end of the sleeve to anchor the proximal portion of the sleeve at the proximal end of the intestine,

wherein the drug is selected from a group consisting of Leptin, Glucagon-Like Peptide-1 (GLP-1), Cholecystokinin (CCK), and insulin.

3. A gastrointestinal implant device comprising:

a flexible sleeve, open at both ends and configured to extend into the intestine and to receive chyme from the stomach, the flexible sleeve being impregnated with a drug; and

a collapsible anchor coupled to a proximal end of the sleeve to anchor the proximal portion of the sleeve at the proximal end of the intestine,

wherein the drug is selected from a group consisting of aminosalicylates and corticosteroids.

4. A gastrointestinal implant device comprising:

a flexible sleeve, open at both ends and configured to extend into the intestine and to receive chyme from the stomach, the flexible sleeve within the intestine being impregnated with a drug; and

a collapsible anchor coupled to a proximal end of the sleeve to anchor the proximal portion of the sleeve at the proximal end of the intestine,

wherein the drug is an immune modifier such as azathioprine and methotrexate.

5. A gastrointestinal implant device comprising:

a flexible sleeve, open at both ends and configured to extend into the intestine and to receive chyme from the stomach, the flexible sleeve within the intestine being impregnated with a drug; and

a collapsible anchor coupled to a proximal end of the sleeve to anchor the proximal portion of the sleeve at the proximal end of the intestine,

wherein the drug is an antibiotic such as ampicillin and cipro.