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Releasable nonvolatile mass-label molecules

  • US 8,486,623 B2
  • Filed: 10/19/2006
  • Issued: 07/16/2013
  • Est. Priority Date: 12/10/1996
  • Status: Expired due to Fees
First Claim
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1. A method for multiplexing the detection of a target molecule comprising:

  • (a) obtaining a plurality of probes, each comprising a reactive group, a release group and a mass label comprising a biopolymer;

    (b) contacting the target molecule with the plurality of probes to produce probe;

    target molecule complexes, wherein the target molecule is attached to the reactive group of the probe;

    (c) releasing the mass labels from the probe;

    target molecule complexes to produce released mass labels; and

    (d) determining the mass of the released mass labels by mass spectrometry, whereineach reactive group in a probe;

    target molecule complex is associated with a unique set of mass labels.

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