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Magnetic beads for reducing leukocyte interference in immunoassays

  • US 8,486,721 B2
  • Filed: 07/27/2012
  • Issued: 07/16/2013
  • Est. Priority Date: 06/14/2010
  • Status: Active Grant
First Claim
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1. A method of reducing interference from leukocytes in an analyte immunoassay, comprising:

  • contacting a biological sample containing leukocytes with magnetic beads opsonized to said leukocytes under conditions sufficient to substantially bind the leukocytes in the biological sample to the opsonized magnetic beads; and

    magnetically retaining the opsonized magnetic beads in the biological sample substantially out of contact from an immunosensor to prevent leucocyte interference;

    wherein the opsonized magnetic beads are present in an amount in excess of the leukocytes in the sample sufficient to substantially sequester any leukocytes present in the sample.

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