Techniques for purposing a new compound and for re-purposing a drug
First Claim
1. A method for repurposing a pharmaceutical compound, resulting in a new treatment protocol to salvage a failed drug or an approved drug, the method comprising:
- a) identifying a pharmaceutical compound, wherein the pharmaceutical compound is a drug that has failed in clinical development or an approved drug;
b) creating a computer model for pharmacokinetics and pharmacodynamics of the drug from in vitro or in vivo data obtained from administration of at least a single dose of the drug of (a) from a pre-clinical trial wherein the computer model created is adjusted based on data from in vitro or in vivo studies in animals;
c) performing computer simulations using the computer model with data obtained from administration of different doses of the drug and dosing intervals for different indications and patient populations in at least one phase I clinical trial;
wherein the computer model is an in silico patient that is adjusted according to results of the pre-clinical trial or the at least one phase I clinical trial.
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Abstract
A method for repurposing a pharmaceutical compound. The method includes identifying a pharmaceutical compound, the pharmaceutical compound corresponding to a drug that has failed in clinical development or an approved drug. A mathematical model describing the physiological processes related to at least one disease and the effects of the pharmaceutical compound on the disease is created. The model is adjusted based upon information from preclinical or clinical trials. A new treatment protocol is suggested to salvage the failed drug or a new way to use an approved drug. The suggested treatment protocol is displayed. Systems and computer program products encompassing the above techniques are also disclosed.
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Citations
33 Claims
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1. A method for repurposing a pharmaceutical compound, resulting in a new treatment protocol to salvage a failed drug or an approved drug, the method comprising:
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a) identifying a pharmaceutical compound, wherein the pharmaceutical compound is a drug that has failed in clinical development or an approved drug; b) creating a computer model for pharmacokinetics and pharmacodynamics of the drug from in vitro or in vivo data obtained from administration of at least a single dose of the drug of (a) from a pre-clinical trial wherein the computer model created is adjusted based on data from in vitro or in vivo studies in animals; c) performing computer simulations using the computer model with data obtained from administration of different doses of the drug and dosing intervals for different indications and patient populations in at least one phase I clinical trial; wherein the computer model is an in silico patient that is adjusted according to results of the pre-clinical trial or the at least one phase I clinical trial. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method for repurposing a pharmaceutical compound, resulting in a new treatment protocol to salvage a failed drug or an approved drug, the method comprising
creating a computer model for pharmacokinetics and pharmacodynamics of a drug that has failed in clinical development or an approved drug from in vitro or in vivo data obtained from administration of at least a single dose of the drug from at least one clinical trial to predict one or more clinical outcomes; -
wherein the prediction of one or more clinical outcomes is compared with clinical results from at least one clinical trial and the comparison is used to adjust the computer model, wherein the computer model is an in silico patient that is adjusted according to the clinical results at least from at least one pre-clinical trial; and wherein a new treatment protocol to salvage the failed drug or the approved drug is determined based on computer simulation results. - View Dependent Claims (14)
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15. A method for repurposing a pharmaceutical compound, resulting in a new treatment protocol to salvage a failed drug or an approved drug, the method comprising
creating a computer model for pharmacokinetics and pharmacodynamics of a drug that has failed in clinical development or an approved drug from in vitro or in vivo data obtained from administration of at least a single dose of the drug from at least one clinical trial to predict one or more clinical outcomes; -
wherein the prediction of one or more clinical outcomes is compared with clinical results from at least one clinical trial and the comparison is used to adjust the computer model, wherein the computer model is an in silico patient that is adjusted according to the clinical results at least from at least one phase I clinical trial; and wherein a new treatment protocol to salvage the failed drug or the approved drug is determined based on results of the computer simulation predictions. - View Dependent Claims (16, 17)
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18. A method for repurposing a pharmaceutical compound, resulting in a new treatment protocol to salvage a failed drug or an approved drug, the method comprising
creating a computer model for pharmacokinetics and pharmacodynamics of a drug that has failed in clinical development or an approved drug from in vitro or in vivo data obtained from administration of at least a single dose of the drug from at least one clinical trial to predict one or more clinical outcomes; -
wherein the prediction of one or more clinical outcomes is compared with clinical results from at least one clinical trial and the comparison is used to adjust the computer model, wherein the computer model is an in silico patient that is adjusted according to the clinical results at least from at least phase II clinical trial; and wherein a new treatment protocol to salvage the failed drug or the approved drug is determined based on the computer simulation results. - View Dependent Claims (19)
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20. A method for repurposing a pharmaceutical compound, resulting in a new treatment protocol to salvage a failed drug or an approved drug, the method comprising
creating a computer model for pharmacokinetics and pharmacodynamics of a drug that has failed in clinical development or an approved drug from in vitro or in vivo data obtained from administration of at least a single dose of the drug from at least one clinical trial to predict one or more clinical outcomes; -
wherein the prediction of one or more clinical outcomes is compared with clinical results from at least one clinical trial and the comparison is used to adjust the computer model, wherein the computer model is an in silico patient that is adjusted according to the clinical results at least from at least one phase III clinical trial; and wherein a new treatment protocol to salvage the failed drug or the approved drug is determined based on the computer simulation results. - View Dependent Claims (21)
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22. A method for repurposing a pharmaceutical compound, resulting in a new treatment protocol to salvage a failed drug or an approved drug, the method comprising
creating a computer model for pharmacokinetics and pharmacodynamics of a drug that has failed in clinical development or an approved drug from in vitro or in vivo data obtained from administration of at least a single dose of the drug from at least one clinical trial to predict post-marketing efficacy of the drug, and long term efficacy of the drug, resulting in prediction of one or more clinical outcomes; -
wherein the prediction of one or more clinical outcomes is compared with clinical results from at least one clinical trial and the comparison is used to adjust the computer model, wherein the computer model is an in silico patient that is adjusted according to the clinical results at least from at least one phase IV clinical trial; and wherein a new treatment protocol to salvage the failed drug or the approved drug is determined based on the computer simulation results. - View Dependent Claims (23)
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24. A system for repurposing a pharmaceutical compound, the system comprising:
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identifying a pharmaceutical compound, wherein the pharmaceutical compound is a drug that has failed in clinical development or an approved drug; a computer model for pharmacokinetics and pharmacodynamics of the drug is created based on data of effects of the drug administered in vitro or in vivo to determine the physiological effect of the drug on a disease; a model adjustor that adjusts the computer model based upon results of computer simulations from at least one pre-clinical or at least one clinical trial; a treatment protocol generator that determines a new treatment protocol to salvage the drug that has failed in a clinical development or the approved drug. - View Dependent Claims (25, 26, 27, 28, 29, 30, 31, 32)
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33. A computer program product comprising a non-transitory computer readable media having instructions that allows a computer to implement a process comprising:
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a) identifying a pharmaceutical compound, the pharmaceutical compound corresponding to a drug that has failed in clinical development or an approved drug; b) creating a computer model for pharmacokinetics and pharmacodynamics of the drug based on data of effects of the drug administered in vitro or in vivo to determine the physiological effect of the drug on a disease; c) adjusting the computer model based upon results of computer simulations from at least one pre-clinical or at least one clinical trial; d) determining a new treatment protocol to salvage the failed drug or the approved drug based on the results of computer simulation results; and e) displaying the new treatment protocol in an output window.
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Specification