Rejuvenation or preservation of germ cells

• US 8,489,337 B2
• Filed: 06/24/2010
• Issued: 07/16/2013
• Est. Priority Date: 06/24/2010
• Status: Active Grant

• Current Assignee: Enterprise Science Fund, LLC (Intellectual Ventures LLC)
• Original Assignee: The Invention Science Fund I, L.L.C. (Intellectual Ventures LLC)
• Inventors: Hyde, Roderick A., Jung, Edward K. Y., Wood, Lowell L. Jr.
• Primary Examiner(s): Brusca, John S
• Application Number:
  US12/803,448
• Publication Number:
  US 20110319984A1
• Time in Patent Office: 1,118 Days
• Field of Search: None
• US Class Current: 702/19
• CPC Class Codes: A01N 1/0226 Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
• CPC Class Codes: A61K 35/54 Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
• CPC Class Codes: A61P 15/00 Drugs for genital or sexual disorders for disorders of sex hormones A61P5/24; Contraceptives

Abstract

Certain embodiments disclosed herein include, but are not limited to, at least one of compositions, methods, devices, systems, kits, or products regarding rejuvenation or preservation of germ cells or gametes. Certain embodiments disclosed herein include, but are not limited to, methods of modifying germ cells or gametes, or methods of administering modified germ cells or gametes to at least one biological tissue.

Claims

1. A delivery device, comprising:

a housing including at least one reservoir containing at least one composition including at least one exogenous energy supplying factor including one or more of creatine, phosphocreatine, NADH, FADH₂, or ATP;

the reservoir configured to receive and retain the composition, as well as dispense at least a portion of the composition to at least one reproductive cell or tissue and deliver by way of liposomal endocytosis or electroporation;

further including at least one control circuitry configured to control release of the composition or a portion thereof in response to a signal from a sensor.

2. The delivery device of claim 1, wherein the delivery device is implantable.

3. The delivery device of claim 1, wherein the housing includes one or more ports.

4. The delivery device of claim 3, wherein at least one of the one or more ports includes at least one outlet port or at least one inlet port.

5. The delivery device of claim 3, further including one or more controllable output mechanisms operably linked to the one or more ports to control dispensing of at least a portion of the composition from the at least one reservoir.

6. The delivery device of claim 5, wherein the at least one controllable output mechanism includes at least one of a micropump, valve, or actuator.

7. The delivery device of claim 5, wherein the at least one controllable output mechanism includes at least one thermal or nonthermal gate in communication with the at least one outlet port of the at least one reservoir.

8. The delivery device of claim 5, further including at least one control circuitry configured to control the at least one controllable output mechanism.

9. The delivery device of claim 8, wherein the at least one control circuitry is configured to generate and transmit an electromagnetic control signal.

10. The delivery device of claim 8, further including at least one memory mechanism for storing instructions for generating and transmitting the electromagnetic control signal.

11. The delivery device of claim 8, wherein the at least one control circuitry is configured for time-release of at least a portion of the at least one composition from the at least one reservoir.

12. The delivery device of claim 8, wherein the at least one control circuitry is configured for variable programming control of the at least one controllable output mechanism.

13. The delivery device of claim 8, wherein the at least one control circuitry is configured to control the release of the composition.

14. The delivery device of claim 8, wherein the at least one control circuitry is configured to control at least one of the rate of release, amount of release, or time of release of the composition.

15. The delivery device of claim 8, wherein the at least one control circuitry is configured to generate and transmit an electromagnetic control signal configured to control the at least one controllable output mechanism.

16. The delivery device of claim 11, wherein the at least one control circuitry is configured to control the at least one controllable output mechanism for time-release of at least a portion of the composition from the at least one reservoir.

17. The delivery device of claim 1, wherein the signal represents information from at least one reproductive cell indicator.

18. The delivery device of claim 17, wherein the at least one or more reproductive cell indicator includes at least one of a property of the reproductive cell, a property of administering the at least one energy supplying factor to the reproductive cell;

a property of the modified reproductive cell;

a property of administering at least one additional round of an energy supplying factor to a modified reproductive cell;

reproductive cell or tissue apoptosis;

reproductive cell division;

reproductive cell cytoskeletal rearrangement;

reproductive cell mitochondrial quality, quantity, or arrangement;

reproductive cell fertilization success or failure;

or reproductive cell or tissue secretion.

19. The delivery device of claim 1, further including at least one transducer.

20. The delivery device of claim 1, further including at least one receiver.

21. The delivery device of claim 20, wherein the at least one receiver is configured to receive information from at least one distal or remote sensor.

22. The delivery device of claim 20, wherein the receiver is configured to obtain release instructions or authorization to release the composition.

23. The delivery device of claim 20, wherein the receiver is configured to receive programming instructions or data for the controller.

24. The delivery device of claim 1, further including at least one transmitter.

25. The delivery device of claim 24, wherein the at least one transmitter is configured to transmit information regarding one or more of the date, time, presence or approximate quantity of release of the at least one composition, or information regarding at least one reproductive cell or substance associated with the release of the composition.

26. The delivery device of claim 1, further including at least one power source.

27. The delivery device of claim 1, further including at least one detection material.

28. The delivery device of claim 27, wherein the reservoir is configured for controlled release of at least one detection material.

29. The delivery device of claim 27, wherein the at least one detection material includes at least one of a radioactive, luminescent, colorimetric, fluorescent, or odorous substance.

30. The delivery device of claim 27, wherein the at least one detection material includes at least one of a taggant, contrast agent, or electronic identification device.

31. The delivery device of claim 30, wherein the at least one electronic identification device includes at least one radio frequency identification device.

32. The delivery device of claim 27, wherein the at least one detection material includes at least one of a diamagnetic particle, ferromagnetic particle, paramagnetic particle, super paramagnetic particle, particle with altered isotope, or other magnetic particle.

33. The delivery device of claim 27, wherein the at least one detection material is responsive to at least one of the presence or level of the composition;

or the presence or level of at least one reproductive cell or substance associated with the dispensing of the composition.

34. The delivery device of claim 27, wherein the at least one detection material is responsive to the approximate quantity of at least one of the composition, or at least one reproductive cell or substance associated with the release of the composition.

35. The delivery device of claim 27, wherein the at least one detection material is responsive to at least one of:

enzyme, acid, amino acid, peptide, polypeptide, protein, oligonucleotide, nucleic acid, ribonucleic acid, oligosaccharide, polysaccharide, glycopeptide, glycolipid, lipoprotein, sphingolipid, glycosphingolipid, glycoprotein, peptidoglycan, lipid, carbohydrate, metalloprotein, proteoglycan, chromosome, adhesion molecule, cytokine, chemokine, immunoglobulin, antibody, antigen, platelet, extracellular matrix, blood plasma, cell wall, hormone, organic compound, inorganic compound, salt, or cell ligand.

36. The delivery device of claim 1, further including at least one sensor.

37. The delivery device of claim 36, wherein the at least one sensor is configured to receive information associated with at least one of temperature, pH, inflammation, presence of at least one substance, detection material, or biological response to administration of the composition.

38. The delivery device of claim 36, further including a controller configured to respond to the at least one sensor.

39. The delivery device of claim 1, further including at least one imaging apparatus capable of imaging the approximate quantity within a treatment region relating to at least one of the composition;

at least one reproductive cell, or at least one substance associated with dispensing the composition.

40. The delivery device of claim 1, further including at least one memory location for recording information related to sensing information, imaging information, transmitting information, or other information related to the delivery device.

41. The delivery device of claim 40, wherein the at least one memory location is configured to record information regarding at least one sensor.

42. The delivery device of claim 40, wherein the at least one memory location is configured to record information regarding at least one of a sensed condition, history, or performance of the device.

43. The delivery device of claim 40, wherein the at least one memory location is configured to record information regarding one or more of the date, time, presence or approximate quantity of at least one of the administered composition;

or at least one reproductive cell or substance associated with the dispensing of the composition.

44. The delivery device of claim 43, wherein the at least one reproductive cell or substance associated with dispensing of the composition includes at least one of an organic or inorganic small molecule, nucleic acid, amino acid, peptide, polypeptide, protein, glycopeptide, glycoprotein, glycolipid, lipopolysaccharide, peptidoglycan, proteoglycan, lipid, lipoprotein, glycospingolipid, metalloprotein, liposome, chromosome, nucleus, acid, base, buffer, protic solvent, aprotic solvent, carbohydrate, ATP, creatine, lactate, phosphocreatine, pyruvate, glucose, lipopolysaccharide, vitamin, mineral, cytokine, chemokine, antibody, element, hormone, virus, enzyme, oligonucleotide, ribonucleic acid, oligosaccharide, polysaccharide, adhesion molecule, NADH, FADH₂, estrogen, progesterone, testosterone, thyroxine, corticotrophin-releasing hormone, follicle-stimulating hormone, gonadotropin-releasing hormone, growth hormone, growth hormone-releasing hormone, insulin, oxytocin, luteinizing hormone, leptin, prolactin, cortisol, aldosterone, estradiol, estriol, estrone, DHEA, DHT, germ cell, gametegonium, gamete, reproductive supporting cell, oogonium, primary oocyte, secondary oocyte, ootid, ovum, polar body, follicular cell, granulosa cell, cumulus cell, spermatogonia, primary spermatocyte, secondary spermatocyte, spermatid, spermatozoa, Sertoli cell, or Leydig cell.

45. The delivery device of claim 40, further including at least one information transmission mechanism configured to transmit information recorded by the at least one memory location.

46. The delivery device of claim 1, wherein the device is substantially in the form of one or more of a patch, oral inhaler, nasal spray or other orifice spray, iontophoretic apparatus, oral consumable, ocular or otic dropper or spray, stent, shunt, orifice insert, ductal implant, organ implant, orifice spray or inhaler, sutures, surgical staples, bandages, micro-electromechanical device, nano-electromechanical device, or absorbable mesh.

47. The delivery device of claim 1, further including one or more inlet mechanisms for receiving external delivery of the at least one composition.

48. A delivery device, comprising:

a housing including at least one reservoir containing at least one composition including at least one exogenous energy supplying factor including one or more of creatine, phosphocreatine, NADH, FADH₂, or ATP;

the reservoir configured to receive and retain the at least one composition, as well as dispense at least a portion of the composition to at least one reproductive cell or tissue by way of liposomal endocvstosis or electroporation; and

further including a receiver, wherein the receiver is configured to obtain release instructions or authorization to release the composition.

49. The delivery device of claim 48, wherein the delivery device is implantable.

50. The delivery device of claim 48, wherein the housing includes one or more ports.

51. The delivery device of claim 48, further including one or more controllable output mechanisms operably linked to the one or more ports to control dispensing of at least a portion of the composition from the at least one reservoir.

52. The delivery device of claim 51, wherein the at least one controllable output mechanism includes at least one of a micropump, valve, or actuator.

53. The delivery device of claim 51, wherein the at least one controllable output mechanism includes at least one thermal or nonthermal gate in communication with the at least one outlet port of the at least one reservoir.

54. The delivery device of claim 51, further comprising at least one control circuitry configured to control the at least one controllable output mechanism.

55. The delivery device of claim 54, wherein the at least one control circuitry is configured to generate and transmit an electromagnetic control signal.

56. The delivery device of claim 55, further including at least one memory mechanism for storing instructions for generating and transmitting the electromagnetic control signal.

57. The delivery device of claim 56, wherein the signal represents information from at least one reproductive cell indicator.

58. The delivery device of claim 48, wherein the at least one or more reproductive cell indicator includes at least one of a property of the reproductive cell, a property of administering the at least one energy supplying factor to the reproductive cell;

a property of the modified reproductive cell;

a property of administering at least one additional round of an energy supplying factor to a modified reproductive cell;

reproductive cell or tissue apoptosis;

reproductive cell division;

reproductive cell cytoskeletal rearrangement;

reproductive cell mitochondrial quality, quantity, or arrangement;

reproductive cell fertilization success or failure;

or reproductive cell or tissue secretion.

59. The delivery device of claim 48, further including at least one transducer.

60. The delivery device of claim 48, wherein the at least one receiver is configured to receive information from at least one distal or remote sensor.

61. The delivery device of claim 48, wherein the receiver is configured to receive programming instructions or data for the controller.

62. The delivery device of claim 48, further including at least one transmitter.

63. The delivery device of claim 62, wherein the at least one transmitter is configured to transmit information regarding one or more of the date, time, presence or approximate quantity of release of the at least one composition, or information regarding at least one reproductive cell or substance associated with the release of the composition.

64. The delivery device of claim 48, further including at least one detection material.

65. The delivery device of claim 48, wherein the reservoir is configured for controlled release of at least one detection material.

66. The delivery device of claim 65, wherein the at least one detection material includes at least one of a diamagnetic particle, ferromagnetic particle, paramagnetic particle, super paramagnetic particle, particle with altered isotope, or other magnetic particle.

67. The delivery device of claim 65, wherein the at least one detection material is responsive to at least one of the presence or level of the composition;

or the presence or level of at least one reproductive cell or substance associated with the dispensing of the composition.

68. The delivery device of claim 65, wherein the at least one detection material is responsive to the approximate quantity of at least one of the composition, or at least one reproductive cell or substance associated with the release of the composition.

69. The delivery device of claim 48, further including at least one sensor.

70. The delivery device of claim 69, wherein the at least one sensor is configured to receive information associated with at least one of temperature, pH, inflammation, presence of at least one substance, detection material, or biological response to administration of the composition.

71. The delivery device of claim 69, further including a controller configured to respond to the at least one sensor.

72. The delivery device of claim 48, further including at least one imaging apparatus capable of imaging the approximate quantity within a treatment region relating to at least one of the composition;

at least one reproductive cell, or at least one substance associated with dispensing the composition.

73. The delivery device of claim 48, further including at least one memory location for recording information related to sensing information, imaging information, transmitting information, or other information related to the delivery device.

74. The delivery device of claim 73, further including at least one information transmission mechanism configured to transmit information recorded by the at least one memory location.

75. The delivery device of claim 48, wherein the device is substantially in the form of one or more of a patch, oral inhaler, nasal spray or other orifice spray, iontophoretic apparatus, oral consumable, ocular or otic dropper or spray, stent, shunt, orifice insert, ductal implant, organ implant, orifice spray or inhaler, sutures, surgical staples, bandages, micro-electromechanical device, nano-electromechanical device, or absorbable mesh.

76. The delivery device of claim 48, further including one or more inlet mechanisms for receiving external delivery of the at least one composition.

77. A delivery device, comprising:

a housing including at least one reservoir containing at least one composition including at least one exogenous energy supplying factor including one or more of creatine, phosphocreatine, NADH, FADH₂, or ATP;

the reservoir configured to receive and retain the at least one composition, as well as dispense at least a portion of the composition to at least one reproductive cell or tissue and deliver the composition by way of liposomal endocytosis or electroporation; and

further including a detection material, wherein the at least one detection material includes at least one of a diamagnetic particle, ferromagnetic particle, paramagnetic particle, super paramagnetic particle, particle with altered isotope, or other magnetic particle.

78. The delivery device of claim 77, wherein the delivery device is implantable.

79. The delivery device of claim 77, wherein the housing includes one or more ports.

80. The delivery device of claim 79, further including one or more controllable output mechanisms operably linked to the one or more ports to control dispensing of at least a portion of the composition from the at least one reservoir.

81. The delivery device of claim 80, wherein the at least one controllable output mechanism includes at least one of a micropump, valve, or actuator.

82. The delivery device of claim 80, wherein the at least one controllable output mechanism includes at least one thermal or nonthermal gate in communication with the at least one outlet port of the at least one reservoir.

83. The delivery device of claim 80, further including at least one control circuitry configured to control the at least one controllable output mechanism.

84. The delivery device of claim 83, wherein the at least one control circuitry is configured to generate and transmit an electromagnetic control signal.

85. The delivery device of claim 84, further including at least one memory mechanism for storing instructions for generating and transmitting the electromagnetic control signal.

86. The delivery device of claim 85, wherein the signal represents information from at least one reproductive cell indicator.

87. The delivery device of claim 86, wherein the at least one or more reproductive cell indicator includes at least one of a property of the reproductive cell, a property of administering the at least one energy supplying factor to the reproductive cell;

a property of the modified reproductive cell;

a property of administering at least one additional round of an energy supplying factor to a modified reproductive cell;

reproductive cell or tissue apoptosis;

reproductive cell division;

reproductive cell cytoskeletal rearrangement;

reproductive cell mitochondrial quality, quantity, or arrangement;

reproductive cell fertilization success or failure;

or reproductive cell or tissue secretion.

88. The delivery device of claim 77, further including at least one transducer.

89. The delivery device of claim 77, further including at least one receiver.

90. The delivery device of claim 89, wherein the at least one receiver is configured to receive information from at least one distal or remote sensor.

91. The delivery device of claim 89, wherein the receiver is configured to obtain release instructions or authorization to release the composition.

92. The delivery device of claim 89, wherein the receiver is configured to receive programming instructions or data for the controller.

93. The delivery device of claim 77, further including at least one transmitter.

94. The delivery device of claim 93, wherein the at least one transmitter is configured to transmit information regarding one or more of the date, time, presence or approximate quantity of release of the at least one composition, or information regarding at least one reproductive cell or substance associated with the release of the composition.

95. The delivery device of claim 77, wherein the reservoir is configured for controlled release of at least one detection material.

96. The delivery device of claim 95, wherein the at least one detection material includes at least one of a diamagnetic particle, ferromagnetic particle, paramagnetic particle, super paramagnetic particle, particle with altered isotope, or other magnetic particle.

97. The delivery device of claim 95, wherein the at least one detection material is responsive to at least one of the presence or level of the composition;

or the presence or level of at least one reproductive cell or substance associated with the dispensing of the composition.

98. The delivery device of claim 95, wherein the at least one detection material is responsive to the approximate quantity of at least one of the composition, or at least one reproductive cell or substance associated with the release of the composition.

99. The delivery device of claim 77, further including at least one sensor.

100. The delivery device of claim 99, wherein the at least one sensor is configured to receive information associated with at least one of temperature, pH, inflammation, presence of at least one substance, detection material, or biological response to administration of the composition.

101. The delivery device of claim 99, further including a controller configured to respond to the at least one sensor.

102. The delivery device of claim 77, further including at least one imaging apparatus capable of imaging the approximate quantity within a treatment region relating to at least one of the composition;

at least one reproductive cell, or at least one substance associated with dispensing the composition.

103. The delivery device of claim 77, further including at least one memory location for recording information related to sensing information, imaging information, transmitting information, or other information related to the delivery device.

104. The delivery device of claim 103, further including at least one information transmission mechanism configured to transmit information recorded by the at least one memory location.

105. The delivery device of claim 77, wherein the device is substantially in the form of one or more of a patch, oral inhaler, nasal spray or other orifice spray, iontophoretic apparatus, oral consumable, ocular or otic dropper or spray, stent, shunt, orifice insert, ductal implant, organ implant, orifice spray or inhaler, sutures, surgical staples, bandages, micro-electromechanical device, nano-electromechanical device, or absorbable mesh.

106. The delivery device of claim 77, further including one or more inlet mechanisms for receiving external delivery of the at least one composition.

107. An implantable delivery device, comprising:

an implantable housing including at least one reservoir with at least one micropump, the reservoir containing at least one composition including at least one exogenous energy supplying factor including one or more of creatine, phosphocreatine, NADH, FADH₂, or ATP;

the reservoir configured to receive and retain the at least one composition, as well as dispense at least a portion of the composition and deliver it to at least one reproductive cell or tissue by way of liposomal endocytosis or electroporation; and

at least one control circuitry configured to control release of the composition or a portion thereof in response to a signal from a sensor.