Method for monitoring the thermal coupling of a measuring cell

• US 8,491,185 B2
• Filed: 12/10/2009
• Issued: 07/23/2013
• Est. Priority Date: 12/18/2008
• Status: Active Grant

• Current Assignee: Roche Diagnostics Operations Incorporated (Roche Holding AG)
• Original Assignee: Roche Diagnostics Operations Incorporated (Roche Holding AG)
• Inventors: Steinboeck, Wolf-Dietrich, Felsberger, Robert, Kraker, Michael, Schneider, Friedrich, Walla, Juergen
• Primary Examiner(s): KAPLAN VERBITSKY, GAIL
• Application Number:
  US12/635,478
• Publication Number:
  US 20100158070A1
• Time in Patent Office: 1,321 Days
• Field of Search: 374/1, 374/10, 374/11, 374/12, 374/4, 374/5, 374/29, 374/30, 374/43, 374/44, 374/45, 374/57, 374/100, 374/102, 374/103, 374/33, 374/31, 374/39, 374/147, 374/148, 374/163, 422/105, 422/108, 422/109, 422/51, 436/137
• US Class Current: 374/44
• CPC Class Codes: G01N 33/4925 measuring blood gas content, e.g. O2, CO2 , HCO3

Abstract

A method for checking the quality of thermal coupling between a measuring cell and a thermostatted element of an analyzer, where the measuring cell can be exchangeably inserted into an analyzer to measure at least one parameter of a sample, and is provided with at least one sensor element in a measuring channel.

Claims

1. A method for checking a quality of a thermal coupling between a measuring cell and a thermostatted element of an analyzer, the measuring cell being exchangeably insertable into the analyzer, and being provided with at least one sensor element in a measuring channel, the method comprising:

(a) establishing mechanical contact with between the measuring cell and the thermostatted element;

(b) filling the measuring channel with a fluid having a known temperature dependent property,

(c) equilibrating the temperature between the measuring channel and the fluid;

(d) applying a rapid temperature change to the measuring channel using the thermostatted element;

(e) measuring over time a signal curve of the at least one sensor element after the rapid temperature change has been applied, wherein the at least one sensor element measures the signal curve over time of the temperature dependent property of the fluid, and

(f) determining the quality of the thermal coupling by analyzing the signal curve over time resulting from the measurements of step (e).

2. The method of claim 1, wherein the fluid is selected from a calibrating fluid, a rinsing fluid, a sample fluid and a quality control fluid.

3. The method of claim 1, wherein the at least one sensor element is used for measuring the at least one parameter of a sample to be analyzed.

4. The method of claim 1, wherein the at least one sensor element measures the signal curve of electrical conductivity, resistance, or impedance of the fluid.

5. The method of claim 1, wherein the sensor element does not determine the temperature of the fluid.

6. A method for checking a quality of a thermal coupling between a measuring cell and a thermostatted element of an analyzer, the measuring cell being exchangeably insertable into the analyzer, and being provided with at least one sensor element in a measuring channel, the method comprising:

(a) establishing mechanical contact with between the measuring cell and the thermostatted element;

(b) filling the measuring channel with a fluid having a known temperature dependent property,

(c) equilibrating the temperature between the measuring channel and the fluid;

(d) applying a rapid temperature change to the measuring channel using the thermostatted element;

(e) measuring over time a signal curve of the at least one sensor element after the rapid temperature change has been applied, wherein the at least one sensor element is a temperature dependent electrochemical sensor element or a temperature dependent optical sensor element, and

(f) determining the quality of the thermal coupling by analyzing the signal curve over time resulting from the measurements of step (e).

7. The method of claim 6, wherein the at least one sensor element is an electrochemical sensor or an optical sensor element for determination of anions or cations in the fluid.

8. The method of claim 7 wherein the cations are selected from Li⁺, Na⁺, K⁺, Mg⁺⁺, and Ca⁺⁺.

9. The method of claim 7, wherein the anions are Cl⁻

.

10. The method of claim 6, wherein the at least one parameter of the sample is a biochemical substance and the at least one sensor element is used for the determination of the biochemical substance.

11. The method of claim 6, wherein the at least one parameter of the sample is a dissolved gas or a pH value and the at least one sensor element measures the dissolved gases or the pH value.

12. The method of claim 6 wherein the sensor element does not determine the temperature of the fluid.

13. The method of claim 6, wherein the fluid is selected from a calibrating fluid, a rinsing fluid, a sample fluid and a quality control fluid.

14. The method of claim 6, wherein the at least one sensor element is used for measuring the at least one parameter of a sample to be analyzed.