Portable, refrigerant-based apparatus and method for rapid systemic patient cooling

• US 8,491,644 B1
• Filed: 02/21/2006
• Issued: 07/23/2013
• Est. Priority Date: 02/22/2005
• Status: Active Grant

• Current Assignee: Medivance Incorporated (Becton, Dickinson & Co)
• Original Assignee: Medivance Incorporated (Becton, Dickinson & Co)
• Inventors: Carson, Gary, Gruzecki, Gary, Whitehead, Steve
• Primary Examiner(s): Dvorak, Linda
• Assistant Examiner(s): SMITH, KAITLYN ELIZABETH
• Application Number:
  US11/360,021
• Time in Patent Office: 2,709 Days
• Field of Search: 607104-106, 165/46
• US Class Current: 607/104
• CPC Class Codes: A61F 2007/0056 for cooling
• CPC Class Codes: A61F 2007/0086 with a thermostat
• CPC Class Codes: A61F 2007/0226 adhesive, self-sticking
• CPC Class Codes: A61F 2007/126 for invasive application, e.g. for introducing into blood vessels
• CPC Class Codes: A61F 7/02 Compresses or poultices for effecting heating or cooling

Abstract

A portable patient cooling apparatus is provided that includes a self-contained refrigerator and on-board power storage supply for stand alone operation. The apparatus is interconnectable to one or more heat exchange devices (e.g. patient contact pads or intravascular catheters) through which a cooled fluid may be circulated for patient cooling. Such fluid may be liquid contained within a reservoir comprising the apparatus during periods of non-use. The apparatus preferably defines a total volume of less than about 0.04 m³, while having a total weight of less than about 15 kg to yield a total circulated fluid cooling capacity of at least 200 watts.

Claims

1. A portable apparatus for circulating a cooled fluid through at least one interconnectable patient heat exchange device, comprising:

a reservoir for containing a fluid;

a circulating pump, fluidly interconnected to said reservoir for portable movement therewith, for circulating said fluid;

a heat exchanger, fluidly interconnected with said circulating pump and said reservoir for portable movement therewith, for cooling said circulatable fluid;

a self-contained refrigerator, fluidly interconnected with said heat exchanger for portable movement therewith, for circulating a refrigerant through said heat exchanger to effect cooling of said circulatable fluid;

a power storage supply, electrically interconnected to said circulating pump and said refrigerator for portable movement therewith, for storing and providing electrical power to electrically power operation of said circulating pump and to electrically power operation of said refrigerator during stand-alone, independent operation of said portable apparatus, free from interconnection of said heat exchanger and said self-contained refrigerator of said portable apparatus with an external electrical energy source; and

,

a patient heat exchange device for external patient contact and fluidly interconnectable to said circulating pump, wherein said fluid is circulatable therethrough by said circulating pump during said stand-alone, independent operation of said portable apparatus.

2. A portable apparatus as recited in claim 1, wherein said portable apparatus has a circulatable fluid cooling capacity of at least about 200 watts during said stand-alone, independent operation.

3. A portable apparatus as recited in claim 2, wherein said apparatus has a circulated fluid cooling capacity of between about 300 watts and 600 watts during said stand-alone, independent operation.

4. A portable apparatus as recited in claim 1, wherein said patient heat exchange device comprises:

at least one patient contact pad for externally contacting a patient, wherein said fluid is a liquid that is circulatable through said at least one patient contact pad to cool a patient at a rate of at least about 1.0 C/hr during said stand-alone, independent operation.

5. A portable apparatus as recited in claim 1, further comprising:

an external housing, wherein said external housing contains said reservoir, circulating pump, heat exchanger, self-contained refrigerator and power storage supply.

6. A portable apparatus as recited in claim 1, further comprising:

a bottom housing and a top panel, wherein said reservoir, circulating pump, heat exchanger, self-contained refrigerator and power storage supply are at least partially disposed between said bottom housing and said top panel.

7. A portable apparatus as recited in claim 1, further comprising:

an external housing, wherein said apparatus defines a total volume, wherein said total volume comprises a bottom layer and an intermediate layer overlying said bottom layer, wherein said refrigerator is located in said intermediate layer, and wherein said intermediate layer is contained within said external housing.

8. A portable apparatus as recited in claim 7, wherein said reservoir is located in said intermediate layer.

9. A portable apparatus as recited in claim 1, wherein said power storage supply comprises:

at least one battery.

10. A portable apparatus as recited in claim 9, wherein said at least one battery is rechargeable.

11. A portable apparatus as recited in claim 1, wherein said power storage supply comprises:

a plurality of rechargeable and replaceable batteries.

15. A portable apparatus as recited in claim 1, wherein said apparatus defines a total volume of less than about 0.04 m³, and wherein said total volume includes said reservoir, circulating pump, heat exchanger, self-contained refrigerator, and power storage supply.

16. A portable apparatus as recited in claim 15, wherein said apparatus defines a total volume of between about 0.01 m³ and 0.02 m³, and wherein said total volume includes said reservoir, circulating pump, heat exchanger, self-contained refrigerator, and power storage supply.

17. A portable apparatus as recited in claim 15, wherein said total volume has a maximum width dimension of less than about 9 inches.

18. A portable apparatus as recited in claim 17, wherein said total volume has a width of between about 4 and 7 inches, a height of between about 6 and 11 inches and a length of between about 9 and 14 inches.

19. A portable apparatus as recited in claim 15, wherein said power storage supply comprises less than about 12% of said total volume.

20. A portable apparatus as recited in claim 19, wherein said power supply comprises between about 8% and 12% of said total volume.

21. A portable apparatus as recited in claim 15, wherein said reservoir comprises less than about 16% of said total volume.

22. A portable apparatus as recited in claim 21, wherein said reservoir comprises between about 8% and 16% of said total volume.

23. A portable apparatus as recited in claim 15, wherein said power supply is located in a bottom layer of said total volume.

24. A portable apparatus as recited in claim 23, wherein said reservoir and said refrigerator are located in side-by-side relation in an intermediate layer of said total volume, said intermediate layer overlying said bottom layer.

25. A portable apparatus as recited in claim 24, wherein said heat exchanger is located in a fluid circulation layer of said total volume, said fluid circulation layer overlying said intermediate layer.

26. A portable apparatus as recited in claim 25, further comprising:

a flow meter, fluidly interconnected with said reservoir, circulating pump, and heat exchanger, for measuring a flow rate of said circulatable liquid and providing an output signal employable in controlling said circulating pump, wherein said flow meter is located in said fluid circulation layer.

27. A portable apparatus as recited in claim 26, wherein said power storage supply is operable to provide electrical power to said flow meter during stand-alone, independent operation of said portable apparatus.

28. A portable apparatus as recited in claim 25, further comprising:

a heater fluidly interconnected with said reservoir, circulating pump and heat exchanger, for heating said circulatable liquid, wherein said heater is located in said fluid circulation layer.

29. A portable apparatus as recited in claim 28, further comprising:

a first liquid temperature sensor located downstream of said heater and upstream of said at least one interconnectable patient heat exchange device, for sensing a temperature of said circulatable fluid and providing a first temperature signal relating thereto; and

,

a second liquid temperature sensor located upstream of said heater and downstream of said at least one interconnectable patient heat exchange device, for sensing a temperature of said circulatable fluid and providing a second temperature signal relating thereto, wherein at least one of said first and second temperature signals is employable in controlling at least one of the circulating pump and the heater.

30. A portable apparatus as recited in claim 28, wherein said power storage supply is operable to provide electrical power to said heater during stand-alone, independent operation of said portable apparatus.

31. A portable apparatus as recited in claim 25, wherein said refrigerator comprises:

at least one condenser;

at least one compressor for circulating the refrigerant through said at least one condenser and said heat exchanger; and

,

at least one fan for circulating ambient air past said at least one condenser.

32. A portable apparatus as recited in claim 31, wherein said refrigerator further comprises;

first and second condensers, wherein said first and second condensers are located along opposing first and second sides at one end of said apparatus, and wherein said at least one fan is located at said one end of the apparatus to circulate ambient air between and past said first and second condensers.

33. A portable apparatus as recited in claim 25, wherein said circulating pump is at least partially located within and supported within a top recess of said reservoir.

34. A portable apparatus as recited in claim 33, wherein said recess is shaped to substantially, conformably receive said circulating pump.

35. A portable apparatus as recited in claim 25, wherein said bottom layer defines between about 8% and 12% of said total volume, said intermediate layer defines between about 50% and 20% of said total volume, and said fluid circulation layer defines between about 10% and 20% of said total volume.

36. A portable apparatus as recited in claim 25, wherein said circulatable fluid is a liquid and wherein said apparatus has a total weight of less than about 15 kg with said reservoir containing at least about 1.2 liters of said liquid.

37. A portable apparatus as recited in claim 36, wherein said apparatus has a total weight of between about 7 kg and 12 kg with said reservoir containing between about 1.2 liters to 2.0 liters of said liquid.

38. A portable apparatus as recited in claim 37, wherein said apparatus has a circulatable fluid cooling capacity of at least about 0.005 watts/cm³ at a weight of less than 0.375 g/cm³.

39. A portable apparatus as recited in claim 38, wherein said apparatus has a circulatable fluid cooling capacity of between about 0.015 watts and 0.03 watts/cm³ at a weight of between about 0.35 g/cm³ and 0.6 g/cm³.

40. A portable apparatus as recited in claim 25, wherein said circulating pump includes an inlet and an outlet located in said fluid circulation layer;

and further comprising;

a flow meter fluidly interconnected with said reservoir, circulating pump and heat exchanger, for measuring a flow rate of said circulatable liquid and providing an output signal employable in controlling said circulating pump, wherein said flow meter is located in said fluid circulation layer;

a heater, fluidly interconnected with said reservoir, circulating pump and heat exchanger, for heating said circulatable liquid, wherein said heater is located in said fluid circulation layer, and wherein a fluid circulation pathway is defined by and between an inlet and outlet port of said circulating pump, said heat exchanger, said flow meter, said heater, and an inlet port and an outlet port of said reservoir, said fluid circulation pathway lying substantially entirely in said fluid circulation layer.

41. A portable apparatus as recited in claim 25, further comprising:

at least one processor, electrically interconnected to said power storage supply, for controlling the operation of said circulating pump and said heater, said processor being located in a top layer overlying said fluid circulation layer; and

,

a user interface operatively interconnected with said processor for establishing control parameters applicable by said processor, said user interface being located in said top layer.

42. A portable apparatus as recited in claim 25, further comprising:

an external housing, wherein said bottom, intermediate and fluid circulation layers are contained within said external housing.

43. A portable apparatus as recited in claim 24, further comprising:

an external housing, wherein said intermediate layer is contained within said external housing.

12. A portable apparatus for circulating a cooled fluid through at least one interconnectable patient heat exchange pad, comprising:

a reservoir for containing a fluid;

a circulating pump, fluidly interconnected to said reservoir for portable movement therewith, for circulating said fluid;

a heat exchanger, fluidly interconnected with said circulating pump and said reservoir for portable movement therewith, for cooling said circulatable fluid;

a self-contained refrigerator, fluidly interconnected with said heat exchanger for portable movement therewith, for circulating a refrigerant through said heat exchanger to effect cooling of said circulatable fluid;

a power storage supply, electrically interconnected to said circulating pump and said refrigerator for portable movement therewith, for providing electrical power to electrically power operation of said circulating pump and to electrically power operation of said self-contained refrigerator during stand-alone, independent operation of said portable apparatus, free from interconnection of said heat exchanger and said self-contained refrigerator of said portable apparatus with an external electrical energy source; and

,

a patient heat exchange pad fluidly interconnectable to the said circulating pump, wherein said fluid is circulatable through the patient heat exchange pad by said circulating pump during said stand-alone, independent operation, wherein said portable apparatus has a circulatable fluid cooling capacity of at least about 200 watts during said stand-alone, independent operation, and wherein said liquid is circulatable through said at least one patient heat exchange pad to cool a patient at a rate of between about 1.5 C/hr to 4.0 C/hr.

13. A portable apparatus as recited in claim 12, wherein said at least one patient heat exchange pad comprises:

a fluid circulation layer having an inlet port and an outlet port; and

,

an adhesive surface for contacting a patient'"'"'s skin, wherein thermal exchange is provided through the adhesive surface.

14. A portable apparatus as recited in claim 12, wherein said circulating pump is fluidly interconnectable with said at least one patient heat exchange pad to circulate said liquid through said at least one patient heat exchange pad under negative pressure during said stand-alone, independent operation of said portable apparatus.

44. A portable apparatus as recited in claim 12, wherein said power storage supply comprises:

at least one battery.

45. A portable apparatus as recited in claim 44, wherein said at least one battery is rechargeable.

46. A portable apparatus as recited in claim 12, wherein said power storage supply comprises:

a plurality of rechargeable and replaceable batteries.