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Aldehyde-fixed, dried platelets with covalently attached exogenous active agent and method of making thereof

  • US 8,492,081 B2
  • Filed: 09/28/2007
  • Issued: 07/23/2013
  • Est. Priority Date: 05/16/2003
  • Status: Expired due to Fees
First Claim
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1. Aldehyde-fixed, dried, mammalian platelets carrying an exogenous active agent,wherein said exogenous active agent is selected from the group consisting of diagnostic agents and therapeutic agents and is covalently coupled to the interior of said aldehyde-fixed, dried, mammalian platelets, andwherein said aldehyde-fixed, dried, mammalian platelets, upon reconstitution, adhere to thrombogenic surfaces, undergo shape change upon adhering to a thrombogenic surface, and lead to the formation of a hemostatic plug upon adhering to a thrombogenic surface.

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