Perfusion assessment method and system based on bolus administration

• US 8,496,591 B2
• Filed: 12/21/2005
• Issued: 07/30/2013
• Est. Priority Date: 12/23/2004
• Status: Expired due to Fees

• Current Assignee: Bracco Suisse SA
• Original Assignee: Bracco Suisse SA
• Inventors: Arditi, Marcel, Frinking, Peter, Rognin, Nicolas
• Primary Examiner(s): Le, Long V.
• Assistant Examiner(s): HOFFA, ANGELA MARIE
• Application Number:
  US11/794,182
• Publication Number:
  US 20080228080A1
• Time in Patent Office: 2,778 Days
• Field of Search: None
• US Class Current: 600/458
• CPC Class Codes: A61B 8/06 Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00
• CPC Class Codes: A61B 8/481 involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream analysis of echo signal exploiting properties of a contrast enhancer in devices for short-range imaging with acoustic waves G01S7/52039

Abstract

A perfusion assessment system is proposed. The system includes means for providing an echo-power signal indicative of a perfusion of a contrast agent in a body-part under analysis, the contrast agent being administered as a bolus and undergoing a significant destruction during a passage of the contrast agent in the body-part, means for associating the echo-power signal to a model function including the product between a bolus function indicative of the passage of the contrast agent without said destruction and a reperfusion function indicative of a reperfusion of the contrast agent in the body part following the destruction corresponding to a substantially constant inflow of the contrast agent, and means for estimating at least one perfusion indicator from the bolus function and/or the reperfusion function.

Claims

1. A perfusion assessment system comprising:

a device configured to;

provide an echo-power signal indicative of a perfusion of a contrast agent in a body part under analysis, the contrast agent being administered as a bolus and undergoing a significant destruction during a passage of the contrast agent in the body part, and

a processor configured to;

associate the echo-power signal to a model function including a mathematical product between a bolus function indicative of the passage of the contrast agent without said destruction and a reperfusion function indicative of a reperfusion of the contrast agent in the body part following the destruction corresponding to a substantially constant inflow of the contrast agent, and

estimate at least one perfusion indicator from the model function, the bolus function, or the reperfusion function.

2. The system according to claim 1, wherein the reperfusion function has an S-shape, the S-shape including an initial portion with substantially zero first derivatives, a final portion with substantially zero first derivatives, and a central portion between the initial portion and the final portion changing monotonically from a value of the initial portion to a value of the final portion.

3. The system according to claim 2, wherein the device is further configured to provide the echo-power signal by processing the echo-power signal to be proportional to a concentration of the contrast agent in the body part.

4. The system according to claim 3, wherein the reperfusion function is a cumulative lognormal function being represented by a set of fitting parameters, and wherein the processor is further configured to estimate the at least one perfusion indicator by deriving the at least one perfusion indicator from the fitting parameters, the at least one perfusion indicator being representative of haemodynamic characteristics of the body part.

5. The system according to claim 3, wherein the reperfusion function is based on a plurality of elementary reperfusion functions with said S-shape each one for a corresponding value of at least one perfusion parameter, the elementary perfusion functions being weighted according to a probability density distribution of the at least one perfusion parameter, and wherein the processor is configured to estimate the at least one perfusion indicator by calculating at least one shape indicator of the probability density distribution, the at least one shape indicator being representative of morphological characteristics of the body part.

6. The system according to claim 2, wherein the reperfusion function is a cumulative lognormal function being represented by a set of fitting parameters, and wherein the estimating comprises deriving the at least one perfusion indicator from the fitting parameters, the at least one perfusion indicator being representative of haemodynamic characteristics of the body part.

7. The system according to claim 2, wherein the reperfusion function is based on a plurality of elementary reperfusion functions with said S-shape, each one for a corresponding value of at least one perfusion parameter, the elementary perfusion functions being weighted according to a probability density distribution of the at least one perfusion parameter, and wherein the processor is further configured to estimate the at least one perfusion indicator by calculating at least one shape indicator of the probability density distribution, the at least one shape indicator being representative of morphological characteristics of the body part.

8. The system according to claim 7, wherein each elementary reperfusion function is a cumulative normal distribution function based on a first predetermined parameter indicative of an echo-power signal measure sensitivity and a second predetermined parameter indicative of a contrast-agent destruction extent.

9. The system according to claim 8, wherein the probability density distribution is a lognormal function of the at least one perfusion parameter and the reperfusion function comprises the integral of the elementary reperfusion functions multiplied by the lognormal function, the lognormal function being represented by a set of fitting parameters, and wherein the processor is further configured to calculate the at least one shape indicator by deriving the at least one shape indicator from the fitting parameters.

10. The system according to claim 8, wherein the probability density distribution is represented by a vector of probabilities, the reperfusion function including the summation of the elementary reperfusion functions multiplied by the corresponding probabilities, and wherein the processor is further configured to calculate the at least one shape indicator by extracting comprises extracting the at least one shape indicator from the vector of probabilities.

11. The system according to claim 7, wherein the probability density distribution is a lognormal function of the at least one perfusion parameter and the reperfusion function comprises the integral of the elementary reperfusion functions multiplied by the lognormal function, the lognormal function being represented by a set of fitting parameters, and wherein the processor is further configured to calculate the at least one shape indicator by deriving the at least one shape indicator from the fitting parameters.

12. The system according to claim 7, wherein the probability density distribution is represented by a vector of probabilities, the reperfusion function including the summation of the elementary reperfusion functions multiplied by the corresponding probabilities, and wherein the processor is further configured to calculate the at least one shape indicator by extracting the at least one shape indicator from the vector of probabilities.

13. The system according to claim 2, wherein the bolus function comprises the sum of a plurality of elementary bolus functions.

14. The system according to claim 1, wherein the bolus function comprises the sum of a plurality of elementary bolus functions.

15. The system according to claim 1, wherein the bolus function and each elementary bolus function is a lognormal function.

16. A diagnostic imaging equipment comprising an ultrasound system for acquiring an echo-power signal, and comprising the perfusion assessment system, according to claim 1.

17. The diagnostic imaging equipment according to claim 16, wherein the device is further configured to detect a reaching of a maximum of the echo-power signal and to trigger the destruction in response to the detection of the reaching of the maximum.

18. A perfusion assessment method including the steps of:

providing an echo-power signal indicative of a perfusion of a contrast agent in a body part under analysis, the contrast agent being administered as a bolus and undergoing a significant destruction during a passage of the contrast agent in the body part,

associating the echo-power signal to a model function including a mathematical product between a bolus function indicative of the passage of the contrast agent without said destruction and a reperfusion function indicative of a reperfusion of the contrast agent in the body part following the destruction corresponding to a substantially constant inflow of the contrast agent, and

estimating at least one perfusion indicator from the model function, the bolus function, or the reperfusion function.

19. A non-transitory computer readable medium comprising instructions, that when executed by processor, cause the method of claim 18 to be performed.

20. A perfusion assessment system comprising:

a device configured to;

provide an echo-power signal indicative of a perfusion of a contrast agent in a body part under analysis, the contrast agent being administered as a bolus and undergoing a significant destruction during a passage of the contrast agent in the body part, and

a hardware structure configured to;

associate the echo-power signal to a model function including a mathematical product between a bolus function indicative of the passage of the contrast agent without said destruction and a reperfusion function indicative of a reperfusion of the contrast agent in the body part following the destruction corresponding to a substantially constant inflow of the contrast agent, and

estimate at least one perfusion indicator from the model function, the bolus function, or the reperfusion function.