Fluid delivery system with spiked cassette

• US 8,496,609 B2
• Filed: 07/05/2007
• Issued: 07/30/2013
• Est. Priority Date: 07/05/2007
• Status: Active Grant

• Current Assignee: Baxter Healthcare SA (Baxter International Inc.), Baxter International Inc.
• Original Assignee: Baxter Healthcare SA (Baxter International Inc.), Baxter International Inc.
• Inventors: Childers, Robert W., Lee, Patrick, Kopychev, Andrey, Reitz, Douglas, Roger, Rodolfo, Steck, John E.
• Primary Examiner(s): Sirmons, Kevin C
• Assistant Examiner(s): GILBERT, ANDREW M
• Application Number:
  US11/773,522
• Publication Number:
  US 20090012448A1
• Time in Patent Office: 2,217 Days
• Field of Search: 604/29, 210/321.6, 417/477.2, 417/477.9, 417/479, 417/480, 417/493, 417/498, 417/502, 417/503, 417/521, 417/531
• US Class Current: 604/29
• CPC Class Codes: A61M 1/14 Dialysis systems; Artificial kidneys; Blood oxygenators semi-permeable membranes characterised by the material, manufacturing processes therefor B01D71/00 ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
• CPC Class Codes: A61M 1/152 Details related to the interface between cassette and machine
• CPC Class Codes: A61M 1/153 the cassette being adapted for heating or cooling the treating fluid, e.g. the dialysate or the treating gas
• CPC Class Codes: A61M 1/154 with sensing means or components thereof
• CPC Class Codes: A61M 1/155 with treatment-fluid pumping means or components thereof
• CPC Class Codes: A61M 1/1561 at least one cassette surface or portion thereof being flexible, e.g. the cassette having a rigid base portion with preformed channels and being covered with a foil
• CPC Class Codes: A61M 1/1565 Details of valves
• CPC Class Codes: A61M 1/159 specially adapted for peritoneal dialysis
• CPC Class Codes: A61M 1/1601 Control or regulation
• CPC Class Codes: A61M 1/1621 Constructional aspects thereof semi-permeable membranes for separation processes characterised by their properties B01D69/00; semi permeable membranes characterised by their material B01D71/00
• CPC Class Codes: A61M 2039/1027 Quick-acting type connectors
• CPC Class Codes: A61M 2205/12 with interchangeable cassettes forming partially or totally the fluid circuit
• CPC Class Codes: A61M 2205/128 with incorporated valves
• CPC Class Codes: A61M 39/165 Shrouds or protectors for aseptically enclosing the connector
• CPC Class Codes: A61M 5/162 Needle sets, i.e. connections by puncture between reservoir and tube ; Connections between reservoir and tube in jet-action syringes A61M5/30; connectors for tubes having sealed ends and a needle for piercing them A61M39/14
• CPC Class Codes: A61M 5/1626 Needle protectors therefor in combination with syringes A61M5/3202; protectors for sharps A61B50/3001
• CPC Class Codes: Y10T 29/49826 Assembling or joining

Abstract

A fluid dispensing machine, such as a peritoneal dialysis or hemodialysis machine, includes a dispenser or cassette that pumps a medical fluid for dialysis or other treatments for patients. The machine includes and uses an autoconnect device for connecting containers of liquid, such as bags of dialysis fluid or medication fluids, to the machine, while maintaining the sterility of the connection. The autoconnect device removes the cap from the fluid bag and pierces a sealing membrane on tubing from the bag. This makes it easier for patients to receive treatment, especially home treatment. The cassettes preferably have tubing ports with integral spikes for piercing the membrane on tubing from bags of liquids. The ports may be staggered for sequential engagement with the spikes. Other embodiments are useful for dispensing other liquids from other types of dispensing or pumping machines.

Claims

1. A dialysis system including a cassette for use with a dialysis machine, the system comprising:

a motorized supply line autoconnection mechanism provided by the dialysis machine;

a frame provided by the cassette;

at least one pump chamber within the frame;

first and second flexible membranes joined to opposite sides of the frame;

a plurality of valves for routing liquid within the cassette; and

a plurality of ports of the cassette communicating with the valves, each port comprising an integral spike, wherein the motorized autoconnection mechanism moves a plurality of supply lines automatically so as to be spiked open by the spiked ports of the cassette for connection with sources of dialysis fluid via the supply lines.

2. The dialysis system of claim 1, wherein each port comprises a shroud, the spike recessed within the shroud.

3. The dialysis system of claim 1, wherein the ports and spikes are oriented at about ninety degrees to a longitudinal axis of the cassette.

4. The dialysis system of claim 1, wherein the cassette is suitable for peritoneal dialysis or hemodialysis.

5. The dialysis system of claim 1, further comprising an line-heater.

6. The dialysis system of claim 1, wherein the ports and spikes protrude in sequentially greater distances from the cassette.

7. The dialysis system of claim 1, wherein the spikes protrude different distances from the cassette, the distances differing sequentially by about ⅛

inch to about ½

inch.

8. The dialysis system of claim 1, wherein the autoconnection mechanism is under automatic control of the dialysis machine.

9. A dialysis cassette, comprising:

a frame;

at least one pump chamber within the frame;

first and second flexible membranes joined to opposite sides of the frame;

a plurality of valves for routing liquid within the cassette; and

a plurality of ports arranged in a row and communicating with the valves, each port comprising an integral spike, the ports configured for connection with a source of dialysis fluid, the spikes protruding in sequentially greater distances from the cassette, the distances from about ⅛

inch to about ½

inch.

10. The dialysis cassette of claim 9, wherein the ports also protrude different distances from the cassette, the distances differing from each other by about ⅛

inch to about ½

inch.

11. The dialysis cassette of claim 9, wherein the integral spike comprises three diameters along a length of the spike.

12. The dialysis cassette of claim 9, wherein the ports and spikes are oriented at about ninety degrees to a longitudinal axis of the cassette.

13. The dialysis cassette of claim 9, wherein the cassette further comprises a drain port and separate ports for flow of fluid to and from a patient, and optionally, wherein the ports to and from the patient are adjacent.

14. A dialysis system comprising:

a dialysis machine including a motorized autoconnection mechanism; and

a cassette held in place by the dialysis machine, the cassette including

a rigid frame;

at least one pump chamber within the frame;

a plurality of valves for routing liquid within the cassette;

a plurality of ports communicating with the valves, the ports configured for connection to tubing;

each port including an integral spike and a removable cap covering the integral spike, each cap including a protrusion, the protrusion configured to be grasped and pulled for removal of the cap from the spike; and

first and second flexible membranes joined to opposite sides of the frame, wherein the membranes are configured to cover the at least one pump chamber and the valves and not to cover the ports, and

wherein the motorized autoconnection mechanism moves a plurality of supply lines automatically toward the held-in-place cassette so as to be spiked open by the plurality of spiked ports.

15. The dialysis system of claim 14, wherein the ports comprise an integral recessed spike.

16. The dialysis system of claim 14, wherein the ports comprise an integral recessed spike, the spike having three sequential diameters.

17. The dialysis system of claim 14, wherein the ports comprise an integral recessed spike, the spike having three sequential diameters, a first diameter, a second diameter adjacent the first diameter and larger than the first diameter, and a third diameter adjacent the second diameter and larger than the second diameter.

18. The dialysis system of claim 14, wherein the cassette further comprises adjacent ports for routing dialysis fluid to and from a patient.

19. The dialysis system of claim 14, wherein the ports are perpendicular to a longitudinal axis of the cassette.

20. A dialysis system comprising:

a dialysis machine including a motorized autoconnection mechanism;

a plurality of supply tubes each connected to a supply of dialysate; and

a cassette held by the dialysis machine, the cassette including

a rigid frame;

at least one pump chamber facing a pump and valve actuation side of the frame;

a plurality of valves for routing liquid within the cassette, the valves facing the pump and valve actuation side of the frame;

a plurality of ports communicating with the valves, the ports extending perpendicular to the pump and valve actuation side of the frame, each port also configured for connection to and fluid communication with one of the plurality of supply tubes; and

first and second flexible membranes joined to opposite sides of the frame, wherein the membranes are configured to cover the at least one pump chamber and the valves and not to cover the ports, and

wherein the motorized autoconnection mechanism is so positioned and arranged to automatically grasp and move the plurality of supply tubes together into fluid communication with the plurality of ports.

21. The dialysis system of claim 20, wherein the ports each comprise an outer shroud and an integral recessed spike.

22. The dialysis system of claim 20, wherein the cassette further comprises a drain port and separate ports for flow of fluid to and from a patient, and optionally, wherein the ports to and from the patient are adjacent.

23. The dialysis system of claim 20, further comprising ports for at least one of pH meter, a conductivity meter, and a temperature element.

24. The dialysis system of claim 20, further comprising a heater.

25. The dialysis system of claim 20, wherein the ports protrude different distances from the cassette, the distances differing from each other by about ⅛

inch to about ½

inch.

26. The dialysis system of claim 20, wherein each of the plurality of valves is arranged in an axially perpendicular direction to the pump and valve actuation side of the frame, and the ports extend perpendicularly from the pump and valve actuation side of the frame in a parallel direction as the plurality of valves.