Method and apparatus for delivering an agent to a kidney

• US 8,496,615 B2
• Filed: 04/13/2012
• Issued: 07/30/2013
• Est. Priority Date: 05/31/2007
• Status: Expired due to Fees

• Current Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories Incorporated)
• Inventors: Consigny, Paul M., El-Nounou, Fozan O., Gale, David C., Kramer-Brown, Pamela A.
• Primary Examiner(s): Sirmons, Kevin C
• Assistant Examiner(s): LEE, BRANDY SCOTT
• Application Number:
  US13/446,761
• Publication Number:
  US 20120203174A1
• Time in Patent Office: 473 Days
• Field of Search: 604/509, 604/523, 604 9601-10314
• US Class Current: 604/96.01
• CPC Class Codes: A61F 2/013 Distal protection devices, i.e. devices placed distally in combination with another endovascular procedure, e.g. angioplasty or stenting
• CPC Class Codes: A61L 2300/40 characterised by a specific therapeutic activity or mode of action
• CPC Class Codes: A61L 2300/432 Inhibitors, antagonists A61L2300/402 - A61L2300/43 take precedence
• CPC Class Codes: A61L 2300/62 Encapsulated active agents, e.g. emulsified droplets
• CPC Class Codes: A61L 2430/26 for kidney reconstruction
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61M 2025/0057 Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
• CPC Class Codes: A61M 2025/0073 Tip designed for influencing the flow or the flow velocity of the fluid, e.g. inserts for twisted or vortex flow general flow characteristics A61M2206/10
• CPC Class Codes: A61M 2025/105 having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
• CPC Class Codes: A61M 25/04 in the body, e.g. expansible A61M25/10, A61M16/0488 take precedence
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00

Abstract

A method is described including introducing a delivery device to a point within a renal artery or a renal segmental artery and delivering a treatment agent from the delivery device according to conditions that create a turbulent blood flow and wherein the treatment agent is capable of inhibiting a biological process contributing to nephropathy. In other embodiments, an apparatus and kit are described including a delivery device for insertion to a point within a renal artery or renal segmental artery and delivery of a treatment agent capable of inhibiting a biological process contributing to nephropathy.

Claims

1. An apparatus comprising:

a primary cannula having dimensions suitable for insertion into one of a renal artery or a renal segmental artery, the primary cannula comprising a first end, a second end and a medial portion along a length of the primary cannula between the first end and the second end;

a balloon assembly coupled to the first end of the primary cannula;

a delivery cannula extending through the primary cannula and the balloon assembly, the delivery cannula having an occluded distal end that terminates at a point distal to the balloon assembly; and

at least one longitudinally disposed opening formed through a portion of a wall of the delivery cannula that is between the distal end of the delivery cannula and the balloon assembly, wherein the at least one longitudinally disposed opening is dimensioned to deliver a treatment agent into the renal artery or renal segmental artery in a direction substantially perpendicular to a direction of blood flow to create turbulent conditions within the renal artery or the renal segmental artery.

2. The apparatus of claim 1 further comprising:

a guidewire cannula coupled to the primary cannula to facilitate positioning of the primary cannula within the renal artery or renal segmental artery.

3. The apparatus of claim 1 further comprising:

an inflation cannula having an end terminating within the balloon assembly, the inflation cannula in fluid communication with the balloon assembly.

4. The apparatus of claim 3 wherein the balloon assembly is proximal to the at least one longitudinally disposed opening.

5. The apparatus of claim 3 wherein the balloon assembly is capable of inflating to a diameter which partially occludes the renal artery or the renal segmental artery to create turbulent conditions in addition to the turbulent conditions created by the delivering of the treatment agent from the at least one longitudinally disposed opening.

6. An apparatus comprising;

a delivery cannula having dimensions suitable for insertion into one of a renal artery or a renal segmental artery, wherein a distal portion of the delivery cannula comprises an occluded distal end and at least one longitudinally disposed opening capable of delivering a treatment agent into the renal artery or the renal segmental artery in a direction substantially perpendicular to a direction of blood flow to create turbulent conditions within the renal artery or renal segmental artery;

a balloon coupled to the delivery cannula at a position proximal to the at least one longitudinally disposed opening; and

an inflation cannula having an end terminating within the balloon, the inflation cannula capable of delivering a fluid to the balloon to modify an outer diameter of the balloon.

7. The apparatus of claim 6 wherein the balloon comprises a distal taper wall, a medial working length and a proximal taper wall and the distal taper wall comprises pores along only a region of the distal taper wall defined by a diameter of a lumen of the renal artery or the renal segmental artery.

8. The apparatus of claim 6 wherein the balloon is capable of inflating to a diameter which partially occludes the renal artery or the renal segmental artery to create turbulent conditions in addition to the turbulent conditions created by the delivering of the treatment agent from the at least one longitudinally disposed opening.