Apparatus and method for photodynamic diagnosis and therapy of skin diseases and light source system thereof

• US 8,496,695 B2
• Filed: 06/11/2007
• Issued: 07/30/2013
• Est. Priority Date: 12/15/2006
• Status: Active Grant

• Current Assignee: Korea Electrotechnology Research Institute
• Original Assignee: Korea Electrotechnology Research Institute
• Inventors: Kang, Uk, Bae, Soo Jin, Rim, Geun Hie, Kim, Guang Hoon, Papayan, Geri V.
• Primary Examiner(s): Johnson, III, Henry M
• Application Number:
  US11/811,912
• Publication Number:
  US 20080147053A1
• Time in Patent Office: 2,241 Days
• Field of Search: 128/898, 606/9, 607 88- 94
• US Class Current: 607/88
• CPC Class Codes: A61B 2017/00057 Light
• CPC Class Codes: A61B 2017/00747 Dermatology
• CPC Class Codes: A61B 2090/373 using light, e.g. by using optical scanners
• CPC Class Codes: A61B 5/0071 by measuring fluorescence emission
• CPC Class Codes: A61B 5/441 Skin evaluation, e.g. for skin disorder diagnosis
• CPC Class Codes: A61N 5/0616 Skin treatment other than tanning
• CPC Class Codes: A61N 5/062 Photodynamic therapy, i.e. excitation of an agent
• CPC Class Codes: G01N 21/6456 Spatial resolved fluorescence measurements; Imaging
• CPC Class Codes: G01N 21/6486 Measuring fluorescence of biological material, e.g. DNA, RNA, cells G01N21/6428 takes precedence

Abstract

A system is provided for photodynamic diagnosis and therapy of skin diseases. In particular, a camera head is provided to irradiate a white light, a fluorescent excitation light and a therapeutic light for the photodynamic therapy from the inside of a case onto the skin region being in contact with a view hole. Additionally, a digital color TV camera collects the light from the skin region and outputs a generated image signal. In particular, an image processing and analysis system receives the image signals from the camera head to process, analyze and store the same, displays a color image by the white light, a fluorescent image by the excitation light and the therapeutic light for the photodynamic therapy, obtained by the digital color TV camera, and a synthesized image thereof, and controls the general operations of the camera and the light source system.

Claims

1. A system for photodynamic diagnosis and therapy of skin diseases comprising:

a camera head including a case having a view hole, provided in front thereof, to be in contact with a skin region, a light guide provided in the rear of the case, the camera head being provided to irradiate a white light, a fluorescence excitation light and a therapeutic light for the photodynamic therapy from the inside of the case onto the skin region being in contact with the view hole, and a digital color TV camera collecting the light from the skin region and outputting a generated image signal;

a light source system, connected to the case of the camera head through the light guide capable of light transmission, providing the fluorescence excitation light, the therapeutic light for the photodynamic therapy and the white light simultaneously to be irradiated onto the skin region to the camera head; and

an image processing and analysis system for receiving the image signal from the camera head to process, analyze and store to same, for displaying a color image by the white light, a fluorescence image by the excitation light and the therapeutic light for the photodynamic therapy, obtained by the digital color TV camera, and a synthesized image thereof, and for controlling the general operations of the camera head and the light source system,

wherein the light source system includes a plurality of light sources and a switching path-coupling unit having an empty holder with no mirror and two holders with a dichroic mirror and an opaque mirror respectively for selectively transmitting wavelengths of light emitted from the plurality of light sources.

2. The system of claim 1, wherein the camera head comprises a handle, in which the case and the digital color TV camera are fixedly provided on the top thereof, adapted to be held by a hand.

3. The system of claim 2, wherein the handle further comprises an internal passage and the light guide is inserted and connected to the case through the internal passage.

4. The system of claim 1, wherein the light guide comprises an optical fiber light guide.

5. The system of claim 1, wherein the light guide comprises a liquid light guide.

6. The system of claim 1, wherein an end portion of the light guide is inserted and connected to the case such that the light irradiation direction is toward the view hole, and the light guide is provided in the form of a bundle comprising a plurality of light guides capable of illuminating the skin region at various angles.

7. The system of claim 1, wherein the camera head comprises an optical system, provided in front of the digital color TV camera in the case, for forming an image of the skin region on a TV sensor of the digital color TV camera in a given wavelength range, the optical system comprising a filter exchange unit including a plurality of optical filters for selectively transmitting wavelengths of light reached from the skin region, and an object lens for receiving the light reflected from the skin region.

8. The system of claim 7, wherein the filter exchange unit comprises a long pass barrier emission filter for shielding the excitation light under fluorescence conditions.

9. The system of claim 7 or 8, wherein the filter exchange unit comprises an infrared cut-off filter for cutting off infrared rays under white light observation conditions.

10. The system of any one of claims 7 and 8, wherein the filter exchange unit comprises a color conversion filter for reproducing the skin color itself and improving the color under white light observation conditions.

11. The system of claim 7, wherein the optical system further comprises a focus adjustment unit for adjusting the focus of the object lens.

12. The system of claim 7, wherein the optical system further comprises a dynamic focus system, i.e., a zoom system, for the zoom operation of the object lens.

13. The system of claim 1, wherein the digital color TV camera is connected to a computer of the image processing and analysis system through a high-speed digital interface thereof.

14. The system of claim 13, wherein the digital interface is operated by the computer and IEEE-1394 protocol.

15. The system of claim 1, wherein the main spectrum range of the light emitted from the light source system is 400 nm to 750 nm.

16. The system of claim 1 or 15, wherein the light source system comprises:

a case, through which light is finally output, including a light output unit connected to the end portion of the light guide;

a plurality of light sources operated in the case by receiving electric power from a power unit;

a switching path-coupling unit, provided in the case, for selectively transmitting wavelengths of lights emitted from the plural light sources;

a filter exchange unit, provided between the switching path-coupling unit and the light output unit in the case, including a plurality of optical filters for selectively transmitting wavelengths of light; and

a control unit, communicably connected to the image processing and analysis system through a remote control interface, for controlling the operations of the power unit, the switching path-coupling unit and the filter exchange unit in accordance with signals transmitted from the image processing and analysis system, and controlling the general operations of the light source system.

17. The system of claim 16, wherein a first lamp and a second lamp are provided as light sources in the case so as to emit light on both sides of the switching path-coupling unit 240 in 90°

direction.

18. The system of claim 17, wherein the switching path-coupling unit comprises a frame arranged in an inclined direction between the first and second lamps movably in the inclined direction by a position adjuster driven under the control of the control unit, wherein a dichroic mirror and an opaque mirror are mounted in two holders of three holders in the frame, respectively, and the rest holder remains as an empty holder so as to selectively transmit the lights of the two lamps or the light of one of the two lamps.

19. The system of claim 18, wherein the dichroic mirror has a high light transmissivity in the short wavelength range below 500 nm.

20. The system of claim 17 or 18, wherein the first lamp is a mercury short arc lamp and the second lamp is a tungsten halogen lamp.

21. The system of claim 16, wherein the filter exchange unit comprises a short-wavepass filter, a long-wave-pass filter, a narrow-band-pass filter, a broad-band-pass filter, and a multi-band-pass filter, respectively selected in accordance with fluorescence excitation, photodynamic therapy, and white light observation.

22. A method for photodynamic diagnosis and therapy of skin diseases comprising:

bringing a skin region into contact with a view hole formed in a front surface of a case in a camera head;

illuminating the skin region, brought into contact with the view hole, with a white light using a light guide in the case;

obtaining a color image signal based on a reflected light from the illumination of the white light using a digital color TV camera provided in the rear of the case, and processing and storing the color image signal transmitted from the digital color TV camera using an image processing and analysis system;

illuminating the skin region, brought into contact with the view hole, with an excitation light supplied from a light source system to the inside of the case through the light guide simultaneously with the white light;

obtaining a fluorescence image signal based on fluorescence by the illumination of the excitation light using the digital color TV camera, and processing and storing the fluorescence image signal transmitted from the digital color TV camera using the image processing and analysis system; and

displaying a color image and a fluorescence image obtained by the image processing and analysis system, or a synthesized image thereof, and analyzing the images,

wherein the light source system includes a plurality of light sources and a switching path-coupling unit having an empty holder with no mirror and two holders with a dichroic mirror and an opaque mirror respectively for selectively transmitting wavelengths of light emitted from the plurality of light sources.

23. The method of claim 22 further comprising irradiating a therapeutic light supplied from the light source system to the case through the light guide onto the skin region, brought into contact with the view hole, thus carrying out photodynamic therapy.

24. The method of claim 23, wherein the therapeutic light irradiation for photodynamic therapy comprises recording a measured value of a first fluorescence intensity within a given light wavelength range, and stopping the light irradiation for photodynamic therapy after photobleaching the fluorescence from the first fluorescence intensity value to a designated range.

25. The method of any one of claims 22 to 24, wherein the therapeutic light is irradiated from the light source system through the light guide in the wavelength range of 400 nm to 750 nm and with an output density above 100 mW/cm².

26. The method of claim 22, wherein the fluorescence image is obtained from an autofluorescence light result in a skin tissue according to whether there exists an abnormality in the skin tissue.

27. The method of claim 22, wherein the fluorescence image is obtained from a secondary fluorescence result after injecting a contrast agent into a body.

28. The method of claim 22, wherein the analysis of the color image and the fluorescence image obtained by the image processing and analysis system carries out evaluation of brightness, color and morphological parameter of the skin region.

29. The method of claim 22 further comprising carrying out image correction including brightness using a standard image obtained and stored in advance from a standard object having the same or similar optical characteristics as those of an examination object against the color image and the fluorescence image obtained from the skin region of the examination object.