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Methods for detecting pre-diabetes and diabetes using differential protein glycosylation

  • US 8,497,077 B2
  • Filed: 04/26/2012
  • Issued: 07/30/2013
  • Est. Priority Date: 05/11/2009
  • Status: Active Grant
First Claim
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1. A lectin-binding test device for determining whether a subject has diabetes or pre-diabetes, wherein the lectin-binding test device comprises:

  • a plurality of lectins, wherein the plurality of lectins comprises Aleuria aurantia lectin, Datura stramonium lectin, and Phaseolus vulgaris agglutinin;

    a support for the plurality of lectins; and

    an indicator to detect binding of each of the plurality of lectins to a glycosylated protein in the sample, wherein an increase in binding of Aleuria aurantia lectin, Datura stramonium lectin, and Phaseolus vulgaris agglutinin relative to a non-diabetic control value indicates that the subject has diabetes or pre-diabetes.

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