×

Methods for diagnosing and treating CNS disorders by trans-blood-brain barrier delivery of protein compositions

  • US 8,497,246 B2
  • Filed: 08/20/2007
  • Issued: 07/30/2013
  • Est. Priority Date: 08/18/2006
  • Status: Active Grant
First Claim
Patent Images

1. A method of treating a CNS disorder comprising systemically administering to an individual suffering from the disorder an effective amount of a composition comprising a first and second antibody, wherein:

  • a. the first antibody is an ScFv antibody that is covalently linked to the carboxy terminus of the second antibody;

    b. the second antibody comprises an Fc region capable of crossing the BBB from the brain to the blood; and

    eitheri) the first antibody is capable of crossing the Blood-Brain Barrier (BBB) from the blood to the brain by binding a receptor BBB transport system and the second antibody is capable of interacting with a pathological substance associated with the disorder;

    orii) the second antibody is capable of crossing the Blood-Brain Barrier (BBB) from the blood to the brain by binding a receptor BBB transport system and the first antibody is capable of interacting with a pathological substance associated with the disorder,wherein the ScFv retains at least 10% of its affinity compared to the affinity of the tetrameric immunoglobulin from which ScFv can be derived.

View all claims
  • 4 Assignments
Timeline View
Assignment View
    ×
    ×