Sampling system for use with surface ionization spectroscopy

• US 8,497,474 B2
• Filed: 07/04/2012
• Issued: 07/30/2013
• Est. Priority Date: 03/03/2006
• Status: Active Grant

• Current Assignee: Bruker Scientific LLC (Bruker Corporation)
• Original Assignee: IonSense, Inc. (Bruker Corporation)
• Inventors: Musselman, Brian D.
• Primary Examiner(s): NGUYEN, KIET TUAN
• Application Number:
  US13/541,727
• Publication Number:
  US 20120273675A1
• Time in Patent Office: 391 Days
• Field of Search: 250/288, 250/281, 250/282
• US Class Current: 250/288
• CPC Class Codes: G01N 30/7293 Velocity or momentum separators
• CPC Class Codes: H01J 49/04 Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
• CPC Class Codes: H01J 49/0404 Capillaries used for transferring samples or ions electrospray nozzles H01J49/167
• CPC Class Codes: H01J 49/16 using surface ionisation, e.g. field-, thermionic- or photo-emission

Abstract

In various embodiments of the invention, a device permits more efficient collection and transmission of ions produced by the action of a carrier gas containing metastable neutral excited-state species into a mass spectrometer. In one embodiment of the invention, the device incorporates the source for ionization in combination with a jet separator to efficiently remove excess carrier gas while permitting ions to be more efficiently transferred into the vacuum chamber of the mass spectrometer. In an embodiment of the invention, improved collection of ions produced by the carrier gas containing metastable neutral excited-state species at greater distances from between the position of the analyte and the position of the mass spectrometer are enabled.

Claims

1. A gas ion separator comprising:

(a) at least two substantially co-axial tubes, where a proximal tube of the at least two substantially co-axial tubes is positioned closest to an external ionization source and a distal tube of the at least two substantially co-axial tubes is positioned furthest from the external ionization source, where the proximal tube and the distal tube are spaced such that there is a gap between the proximal tube and the distal tube, where a vacuum region is operably connected to the gap; and

(b) a grid operably connected to the proximal tube.

2. The gas ion separator of claim 1, where the grid is a wire mesh screen.

3. The gas ion separator of claim 1, where the grid is made of metal.

4. The gas ion separator of claim 1, where the gap is spanned by the grid.

5. The gas ion separator of claim 1, where the grid is an open ended mesh cage.

6. The gas ion separator of claim 1, where one or both the proximal tube and the distal tube is made of a material selected from the group consisting of glass, resistively coated glass, glass lined metal tube, coated fused silica, metal coated fused silica, machinable glass, metal coated machinable glass, ceramic, metal coated ceramic and metal.

7. The gas ion separator of claim 1, where the proximal tube is positioned between a region of approximately atmospheric pressure and a region of approximately high vacuum.

8. The gas ion separator of claim 1, further comprising a capacitive surface on one or both the proximal tube and the distal tube.

9. The gas ion separator of claim 8, further comprising a potential applied to the capacitive surface.

10. A gas ion separator comprising:

three or more substantially co-axial tubes; and

a grid operably connected to one of the three or more substantially co-axial tubes, where the three or more substantially co-axial tubes are spaced such that there is one or more gaps between at least two of the three or more substantially co-axial tubes, where a proximal tube of the three or more substantially co-axial tubes is positioned closest to an external ionization source, where at least one of the one or more gaps is operably connected to a vacuum region.

11. The gas ion separator of claim 10, where the proximal tube is positioned between a region of approximately atmospheric pressure and a region of approximately high vacuum.

12. The gas ion separator of claim 10, where the grid spans at least one of the one or more gaps.

13. The gas ion separator of claim 10, further comprising a capacitive surface on one or more of the three or more substantially co-axial tubes.

14. The gas ion separator of claim 13, further comprising a potential applied to the capacitive surface.

15. The gas ion separator of claim 10, where one or more of the three or more substantially co-axial tubes is made of a material selected from the group consisting of glass, resistively coated glass, glass lined metal tube, coated fused silica, metal coated fused silica, machinable glass, metal coated machinable glass, ceramic, metal coated ceramic and metal.

16. A spectroscopic device comprising:

(a) an external ionization source;

(b) a spectroscopic analyzer;

(c) a proximal tube closest to the external ionization source and a distal tube furthest from the external ionization source, where the proximal tube and the distal tube are substantially co-axial, where the proximal tube and the distal tube are spaced such that there is a gap between the proximal tube and the distal tube;

(d) a grid operably connected to the proximal tube; and

(e) a vacuum region operably connected to the gap.

17. The spectroscopic device of claim 16, where the grid is a wire mesh screen.

18. The spectroscopic device of claim 16, where the grid is made of metal.

19. The spectroscopic device of claim 16, where the gap is spanned by the grid.

20. The spectroscopic device of claim 16, where the grid is an open ended mesh cage.