Implantable medical device and method for monitoring synchronicity of the ventricles of a heart

• US 8,498,702 B2
• Filed: 12/22/2008
• Issued: 07/30/2013
• Est. Priority Date: 12/22/2008
• Status: Active Grant

• Current Assignee: St. Jude Medical AB (Abbott Laboratories)
• Original Assignee: St. Jude Medical AB (Abbott Laboratories)
• Inventors: Jrverud, Karin
• Primary Examiner(s): Holmes, Rex R
• Application Number:
  US13/141,385
• Publication Number:
  US 20110257697A1
• Time in Patent Office: 1,681 Days
• Field of Search: 600/481, 600/483, 600508-509, 600/547, 600/515, 600/526, 607 8- 9, 607/28
• US Class Current: 607/9
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61B 5/7239 using differentiation including higher order derivatives
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters

Abstract

In an implantable medical device and a method for monitoring ventricular synchronicity of a heart. In particular, impedance signals are measured and an occurrence of a notch is detected in the impedance signal coincident with a period including a change from rapid to slow filling of a ventricle. The notch is indicated by a first positive slope change in a negative slope in a predetermined time window during a diastolic phase of a cardiac cycle. A degree of synchronicity is determined based on the notch feature, wherein a decreasing notch feature indicates an increased degree of synchronicity in the filling phase of the ventricles.

Claims

1. An implantable medical device for monitoring ventricular synchrony of a heart of patient including a pace pulse generator adapted to produce cardiac stimulating pacing pulses and being connectable to at least one medical lead for delivering bi-ventricular pulses to cardiac tissue of said heart, comprising:

an impedance measuring unit that during impedance measuring sessions, measures an impedance signal using an electrode configuration, said configuration being connectable to said impedance measuring unit and interacting with said patient;

a notch detecting unit that detects an occurrence of a notch in the impedance signal coincident with a period including a change from rapid to slow filling of a ventricle, said notch being indicated by a first positive slope change in a negative slope in a predetermined time window during a diastolic phase of a cardiac cycle, wherein a portion of the impedance signal within a time window surrounding said notch being a notch impedance curve;

a notch feature determining unit that determines a notch feature using said notch impedance curve;

a synchronicity determining unit that determines a degree of synchronicity based on said notch feature, wherein a decreasing notch feature indicates an increased degree of synchronicity in the filling phase of the ventricles; and

a VV delay determining unit adapted to perform an optimization procedure, and wherein said pace pulse generator is controlled to, based on said notch feature, iteratively adjust a VV-interval so as to minimize said notch feature to obtain substantially synchronized ventricle contractions.

2. The implantable medical device according to claim 1, wherein said notch detecting unit detects the notch as the first positive slope change in the negative slope in the predetermined time window during the diastolic phase of the cardiac cycle, wherein said predetermined time window starting a predetermined period of time from the end of the systolic phase.

3. The implantable medical device according to claim 1, wherein said notch feature determining unit that calculates a first derivative of the measured impedance signal, said notch being indicated by the first positive slope change after a zero derivative of said impedance signal.

4. The implantable medical device according to claim 3, wherein said notch feature determining unit determines the notch feature based on:

a notch start point, said notch start point being measured from the first point of a second zero derivative of said impedance signal after a T-wave;

a notch width, said notch width being determined to be a distance from the notch to the first point of a third zero derivative after the notch;

a notch area, said notch area being determined to be an area of the differentiated notch impedance curve between the notch and the first point of the third zero derivative after the notch or between two intersection points of the differentiated notch impedance curve and a threshold relative to the maximum of the derivate derivative of the notch impedance cure.

5. The implantable medical device according to claim 1, comprising a breath rate sensor that senses a breathing cycle of said patient, and wherein said notch feature determining unit determines said notch feature in synchronism with an event of said a breathing cycle of said patient or as an average value over a predetermined number of breathing cycles.

6. The implantable medical device according to claim 1 comprising a body posture sensor that senses a body posture of said patient, and wherein said notch feature determining unit determines said notch feature in synchronism with a predetermined body posture of said patient, or as an average value of the notch feature of at least two body postures.

7. The implantable medical device according to claim 1, wherein said notch feature determining unit determines a shape of notch impedance curve to be said notch feature.

8. The implantable medical device according to claim 7, further comprising a VV delay determining circuit that performs an optimization procedure, and wherein said pace pulse generator is controlled to, based on said notch feature, iteratively adjust a VV-interval so as to obtain a smooth notch impedance curve.

9. The implantable medical device according to claim 1, wherein said synchronicity detecting unit compares said notch feature with a reference notch feature to obtain a comparison result and to determine the degree of synchronicity based on said comparison result.

10. The implantable medical device according to claim 9, wherein said synchronicity detecting unit executes a pattern comparison with a reference impedance curve to obtain said comparison result and to determine the degree of synchronicity based on said comparison result.

11. The implantable medical device according to claim 1, further comprising an IEGM detecting unit that senses IEGM signals for consecutive cardiac cycles of said heart and that detects cardiac events in said IEGM signals, and wherein said notch detecting unit detects the occurrence of a notch within said predetermined time window, said time window having a predetermined length of time and starting a predetermined period of time after the detection of a T-wave in an IEGM signal corresponding to a cardiac cycle.

12. The implantable medical device according to claim 1, wherein said impedance signal is measured using an electrode configuration including at least a first pair of electrodes having a ring electrode and a tip electrode arranged in a medical lead located in the right ventricle, or a first electrode located adjacent to the septum in the right ventricle and a second electrode located in a coronary vein on the left ventricle.

13. A method for monitoring ventricular synchrony of a heart of a patient in an implantable medical device including a pace pulse generator that emits cardiac stimulating pacing pulses and is connectable to at least one medical lead for delivering bi-ventricular pulses to cardiac tissue of said heart, comprising:

during impedance measuring sessions, measuring an impedance signal using an electrode configuration being connectable to an impedance measuring unit and interacting with said patient, and generating a corresponding impedance signal;

detecting an occurrence of a notch in the impedance signal coincident with a period including a change from rapid to slow filling of a ventricle, said notch being indicated by a first positive slope change in a negative slope in a predetermined time window during a diastolic phase of a cardiac cycle, wherein a portion of the impedance signal within the time window surrounding said notch being a notch impedance curve;

determining a notch feature using said notch impedance curve;

determining a degree of synchronicity based on said notch feature, wherein a decreasing notch feature indicates an increased degree of synchronicity in the filling phase of the ventricles; and

performing an optimization procedure based on said notch feature by iteratively adjusting a VV-interval so as to minimize said notch feature to obtain substantially synchronized ventricle contractions.

14. The method according to claim 13, wherein said detecting includes detecting the notch as the first positive slope change in the negative slope in the predetermined time window during the diastolic phase of the cardiac cycle, wherein said predetermined time window starts a predetermined period of time from the end of the systolic phase.

15. The method according to claim 13, wherein said determining includes calculating a first derivative of the measured impedance signal, said notch being indicated by the first positive slope change after a zero derivative of said impedance signal.

16. The method according to claim 15, wherein said determining includes determining the notch feature based on:

a notch start point, said notch start point being measured from the first point of a second zero derivative of said impedance signal after a T-wave;

a notch width, said notch width being determined to be a distance from the notch to the first point of a third zero derivative after the notch; and

a notch area, said notch area being determined to be an area of the differentiated notch impedance curve between the notch and the first point of the third zero derivative after the notch or between two intersection points of the differentiated notch impedance curve and a threshold relative to the maximum of the derivate derivative of the notch impedance curve.

17. The method according claim 13, further including sensing a breathing cycle of said patient and determining said notch feature in synchronism with an event of said breathing cycle of said patient or as an average value over a predetermined number of breathing cycles.

18. The method according to claim 13, further comprising sensing a body posture of said patient and determining said notch feature in synchronism with a predetermined body posture of said patient, or as an average value of the notch feature of at least two body postures.

19. The method according to claim 13, wherein said determining includes determining a shape of notch impedance curve to be said notch feature.

20. The method according to claim 19, further comprising performing an optimization procedure based on said notch feature by iteratively adjusting a VV-interval so as to obtain a smooth notch impedance curve.

21. The method according to claim 13, further comprising comparing said notch feature with a reference notch feature to obtain a comparison result and to determine the degree of synchronicity based on said comparison result.

22. The method according to claim 21, further comprising implementing a pattern comparison with a reference impedance curve to obtain a comparison result to determine the degree of synchronicity based on said comparison result.

23. The method according to claim 13, further comprising sensing IEGM signals for consecutive cardiac cycles of said heart and to detect cardiac events in said IEGM signals and detecting the occurrence of a notch within said predetermined time window, said time window having a predetermined length of time and starting a predetermined period of time after the detection of a T-wave in an IEGM signal corresponding to a cardiac cycle.

24. The method according to claim 13, further comprising measuring the impedance using an electrode configuration including at least a first pair of electrodes having a ring electrode and a tip electrode arranged in a medical lead located in the right ventricle, or a first electrode located adjacent to the septum in the right ventricle and a second electrode located in a coronary vein on the left ventricle.

25. A method for optimizing lead and/or electrode locations, said comprising a plurality of electrodes being connectable to an implantable medical device comprising a pace pulse generator that emits cardiac stimulating pacing pulses and is connectable to at least one medical lead for delivering stimulation pulses to cardiac tissue of a heart, comprising:

a) measuring an impedance signal at a first electrode configuration, wherein the electrodes of said electrode configuration are connectable to said implantable medical device and are located at a right side of said heart;

b) detecting an occurrence of a notch in the impedance signal coincident with a period including a change from rapid to slow filling of a ventricle, said notch being indicated by a first positive slope change in a negative slope in a predetermined time window during a diastolic phase of a cardiac cycle, wherein a portion of the impedance signal within the time window surrounding said notch being a notch impedance curve;

c) determining a notch feature using said notch impedance curve for said electrode configuration;

d) determining a degree of synchronicity based on said notch feature for said electrode configuration, wherein a decreasing notch feature indicates an increased degree of synchronicity in the filling phase of the ventricles;

e) performing an optimization procedure based on said notch feature by iteratively adjusting a VV-interval so as to minimize said notch feature in said predetermined time window for said first electrode configuration to determine a minimum notch feature;

f) repeating (a)-(e) for at least a second electrode configuration;

g) comparing said minimum notch feature for each configuration to identify an overall minimum notch feature; and

h) selecting the electrode configuration being associated with the minimum notch feature.

26. A system for optimizing lead and/or electrode locations including a plurality of electrodes and an implantable medical device, said system comprising:

at least one medical lead arrangement comprising said plurality of electrodes in an electrode configuration;

a pace pulse generator that produces cardiac stimulating pacing pulses and is connected to said at least one medical lead arrangement for delivering stimulation pulses to cardiac tissue of a heart of a patient;

an impedance measuring unit that, during impedance measuring sessions, measures an impedance signal obtained at the electrode configuration connected to said impedance measuring unit and interacting with said patient, wherein the electrodes of said electrode configuration are located at a right side of said heart;

a notch detecting unit that detects an occurrence of a notch in the impedance signal coincident with a period including a change from rapid to slow filling of a ventricle, said notch being indicated by a first positive slope change in a negative slope in a predetermined time window during a diastolic phase of a cardiac cycle, wherein a portion of the impedance signal within a time window surrounding said notch being a notch impedance curve;

a notch feature determining unit that determines a notch feature using said notch impedance curve;

a synchronicity determining unit that determines a degree of synchronicity based on said notch feature; and

an external control unit in connection with said implantable medical device and being configured to;

instruct said implantable medical device to obtain a notch feature for at least a second electrode configuration;

compare said notch feature for each configuration to identify a minimum notch feature; and

select the electrode configuration being associated with the minimum notch feature.

27. A pacing analyzer for optimizing lead and/or electrode locations being connectable to at least one medical lead implantable in a heart of a patient and defining at least one medical lead arrangement comprising electrodes in an electrode configuration, said analyzer comprising:

a pace pulse generator that emits cardiac stimulating pacing pulses and connected to said at least one medical lead arrangement for delivering stimulation pulses to cardiac tissue of a heart of a patient;

an impedance measuring unit that, during impedance measuring sessions, measures an impedance signal obtained at the electrode configuration connected to said impedance measuring unit and interacting with said patient, wherein the electrodes of said electrode configuration are located at a right side of said heart;

a notch detecting unit that detects an occurrence of a notch in the impedance signal coincident with a period including a change from rapid to slow filling of a ventricle, said notch being indicated by a first positive slope change in a negative slope in a predetermined time window during a diastolic phase of a cardiac cycle, wherein a portion of the impedance signal within a time window surrounding said notch being a notch impedance curve;

a notch feature determining unit that determines a notch feature using said notch impedance curve;

a synchronicity determining unit that determines a degree of synchronicity based on said notch feature, wherein a decreasing notch feature indicates an increased degree of synchronicity in the filling phase of the ventricles;

a VV delay determining unit that executes an optimization procedure, wherein said pace pulse generator is controlled to, based on said notch feature, iteratively adjust a VV-interval so as to minimize said notch feature in said predetermined time window to determine a minimum notch feature; and

a control unit configured to;

compare said minimum notch feature for different electrode and/or lead configurations to identify an overall minimum notch feature; and

indicate the electrode configuration being associated with the overall minimum notch feature.