Integrated system and method for treating disease using cognitive-training and brain stimulation and computerized magnetic photo-electric stimulator (CMPES)

• US 8,498,708 B2
• Filed: 05/13/2008
• Issued: 07/30/2013
• Est. Priority Date: 09/13/2004
• Status: Expired due to Fees

• Current Assignee: Neuronix Ltd.
• Original Assignee: Neuronix Ltd.
• Inventors: Bentwich, Jonathan
• Primary Examiner(s): MALAMUD, DEBORAH LESLIE
• Application Number:
  US12/153,037
• Publication Number:
  US 20080262565A1
• Time in Patent Office: 1,904 Days
• Field of Search: 607 1- 3, 607/45, 607 55- 57, 607/89, 607100-103, 607/115, 607/139, 607/142, 607/148, 607/154, 607155-156, 600/9, 600 11- 15, 600544-545
• US Class Current: 607/45
• CPC Class Codes: A61B 5/4088 Diagnosing of monitoring cognitive diseases, e.g. Alzheimer, prion diseases or dementia
• CPC Class Codes: A61N 1/36025 for treating a mental or cerebral condition
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/36092 Mental training
• CPC Class Codes: A61N 2/002 in combination with another treatment
• CPC Class Codes: A61N 2/006 for magnetic stimulation of nerve tissue
• CPC Class Codes: A61N 5/0616 Skin treatment other than tanning
• CPC Class Codes: A61N 5/067 using laser light

Abstract

An integrated system and method for treatment of various diseases, including psychiatric, mental and brain disorders, which preferably combines personalized non-invasive neuronal brain stimulation together with appropriate personalized cognitive training, and which iteratively fine-tunes this treatment by monitoring specific cognitive and brain functions in response to the treatment. A novel brain stimulator device and method, Computerized Magnetic Photo-Electric Stimulator (CCMPES), is described, which integrates electromagnetic stimulation with laser stimulation to generate a magnetic photo-electric stimulation.

Claims

1. A medical device, comprising:

a non-invasive electromagnetic brain stimulator configured to provide stimulation of at least one specific brain region of a subject;

a computerized cognitive brain stimulator that runs a program, stored on a non-transitory computer readable storage medium, that administers a memory stimulation to a subject; and

an integrated treatment controller device that concurrently operates the electromagnetic brain stimulator in conjunction with the cognitive brain stimulator.

2. The medical device according to claim 1, wherein said medical device further comprises an analyzer operative to modulate operation of the medical device based at least in part on comparison of a measurement of a property in the subject to a norm of said property, which property is a localized brain feature or a cognitive feature.

3. The medical device according to claim 1, further comprising a feedback modulator operative to modulate operation of the medical device based at least in part on detection and analysis of alteration of a property following operation of the medical device, which property is a localized brain feature or a cognitive feature.

4. The medical device according to claim 3, wherein said integrated treatment controller modify its instructions to the stimulator, as to the type and intensity of the neuronal and cognitive stimuli to be applied to the patient, based on the feedback data provided by the feedback modulator.

5. The medical device according to claim 1, wherein said medical device further comprises an analyzer operative to modulate operation of the medical device based at least in part on comparison of a measurement of the cognitive performance of the subject.

6. A method for treatment of a neurodegenerative disease in a patient, using the medical device in accordance with claim 1, the method comprising:

using the non-invasive electromagnetic brain stimulator to stimulate at least one region of a brain of the patient with magnetic stimulation or with electric stimulation, which at least one region is a specific brain region associated with said disease; and

concurrently using the computerized cognitive brain stimulator to administer a memory stimulation to the patient.

7. The method according to claim 6, wherein said method further comprises analyzing alteration of a localized brain feature or a cognitive feature following operation of the medical device, modulating at least one of the stimulating at least one region of a brain of the patient or the stimulating at least one cognitive feature in the patient.

8. The method according to claim 6, wherein the neurodegenerative disease is Alzheimer'"'"'s disease.