Cassette system integrated apparatus

• US 8,499,780 B2
• Filed: 10/24/2011
• Issued: 08/06/2013
• Est. Priority Date: 02/27/2007
• Status: Active Grant

• Current Assignee: Deka Products Limited Partnership
• Original Assignee: Deka Products Limited Partnership
• Inventors: Wilt, Michael J., Grant, Kevin L., Dale, James D., Demers, Jason A., Tracey, Brian
• Primary Examiner(s): SCHNEIDER, CRAIG M
• Application Number:
  US13/280,274
• Publication Number:
  US 20120106289A1
• Time in Patent Office: 652 Days
• Field of Search: 137/833, 137/99, 137/100, 137/565.3, 417/477.2, 417/479, 417/480
• US Class Current: 137/100
• CPC Class Codes: A61M 1/14 Dialysis systems; Artificial kidneys; Blood oxygenators semi-permeable membranes characterised by the material, manufacturing processes therefor B01D71/00 ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
• CPC Class Codes: A61M 1/153 the cassette being adapted for heating or cooling the treating fluid, e.g. the dialysate or the treating gas
• CPC Class Codes: A61M 1/154 with sensing means or components thereof
• CPC Class Codes: A61M 1/155 with treatment-fluid pumping means or components thereof
• CPC Class Codes: A61M 1/15625 the reservoirs acting as balance chambers
• CPC Class Codes: A61M 1/1563 Details of incorporated filters
• CPC Class Codes: A61M 1/1565 Details of valves
• CPC Class Codes: A61M 1/16 with membranes
• CPC Class Codes: A61M 1/1601 Control or regulation
• CPC Class Codes: A61M 1/1639 linked by membranes
• CPC Class Codes: A61M 1/1656 Apparatus for preparing dialysates
• CPC Class Codes: A61M 1/1658 Degasification
• CPC Class Codes: A61M 1/166 Heating for sterilisation A61M1/1686
• CPC Class Codes: A61M 2205/12 with interchangeable cassettes forming partially or totally the fluid circuit
• CPC Class Codes: A61M 2205/3317 Electromagnetic, inductive or dielectric measuring means
• CPC Class Codes: A61M 2205/3324 PH measuring means
• CPC Class Codes: A61M 2205/3331 Pressure; Flow
• CPC Class Codes: A61M 2205/3368 Temperature
• CPC Class Codes: A61M 60/113 in other functional devices, e.g. dialysers or heart-lung machines
• CPC Class Codes: A61M 60/268 the displacement member being flexible, e.g. membranes, diaphragms or bladders
• CPC Class Codes: A61M 60/37 : Haemodialysis, haemofiltration or diafiltration
• CPC Class Codes: A61M 60/427 : the force acting on the blood contacting member being hydraulic or pneumatic
• CPC Class Codes: A61M 60/43 : using vacuum at the blood pump, e.g. to accelerate filling
• CPC Class Codes: A61M 60/523 : using blood flow data, e.g. from blood flow transducers
• CPC Class Codes: A61M 60/546 : of blood flow, e.g. by adapting rotor speed
• CPC Class Codes: A61M 60/847 : arranged in a cassette
• CPC Class Codes: A61M 60/851 : Valves
• CPC Class Codes: F04B 13/02 : of two or more fluids at the same time
• CPC Class Codes: F04B 43/02 : having plate-like flexible members, e.g. diaphragms F04B43/14 takes precedence
• CPC Class Codes: F04B 43/06 : Pumps having fluid drive
• CPC Class Codes: F04B 43/073 : the actuating fluid being controlled by at least one valve
• CPC Class Codes: F04B 43/0733 : with fluid-actuated pump inlet or outlet valves; with two or more pumping chambers in series
• CPC Class Codes: F04B 45/053 : Pumps having fluid drive
• CPC Class Codes: F04B 45/0536 : the actuating fluid being controlled by one or more valves
• CPC Class Codes: F04B 53/106 : the valve being a membrane
• CPC Class Codes: F04B 53/1062 : fixed at two or more points at its periphery
• CPC Class Codes: F04B 9/109 : having plural pumping chambers
• CPC Class Codes: F16K 99/0015 : Diaphragm or membrane valves
• CPC Class Codes: Y10T 137/0329 : Mixing of plural fluids of diverse characteristics or conditions
• CPC Class Codes: Y10T 137/2521 : Flow comparison or differential response
• CPC Class Codes: Y10T 137/2931 : Diverse fluid containing pressure systems
• CPC Class Codes: Y10T 137/7879 : Resilient material valve
• CPC Class Codes: Y10T 137/85978 : With pump
• CPC Class Codes: Y10T 137/86139 : Serial

Abstract

A cassette integrated system. The cassette integrated system includes a mixing cassette, a balancing cassette, a middle cassette fluidly connected to the mixing cassette and the balancing cassette and at least one pod. The mixing cassette is fluidly connected to the middle cassette by at least one fluid line and the middle cassette is fluidly connected to the balancing cassette by at least one fluid line. The at least one pod is connected to at least two of the cassettes wherein the pod is located in an area between the cassettes.

Claims

1. A cassette assembly comprising:

a first cassette, a second cassette and a third cassette, the second cassette interposed between the first cassette and the third cassette, and spaced apart from the first cassette and the third cassette;

each cassette comprising a plurality of fluid flow paths and one or more valves, the second cassette being connected to the first and third cassettes by one or more fluid conduits;

a reciprocating positive displacement membrane pump pod having an actuation chamber separated from a pumping chamber by a flexible membrane, the pump pod having an actuation port communicating with the actuation chamber and at least one fluid port communicating with the pumping chamber, the pump pod positioned between the first cassette and the second cassette, and the actuation port and the fluid port each communicating with a flow path in one of the first cassette and the second cassette;

a fluid flow balancing pod having a first balance chamber separated from a second balance chamber by a flexible membrane, the balancing pod having a first fluid port communicating with the first balance chamber and a second fluid port communicating with the second balance chamber, the balancing pod positioned between the second cassette and the third cassette, each said fluid port communicating with a flow path in one of the second cassette and the third cassette;

wherein

the pump pod is configured to pump an amount of a first fluid from the pumping chamber into the first balance chamber via the fluid port of the first balance chamber, and the balancing pod is configured to displace a substantially equal amount of a second fluid out of the second balance chamber via the fluid port of the second balance chamber.

2. The cassette assembly of claim 1, wherein each said cassette comprises a top plate, a mid-plate and a bottom plate.

3. The cassette assembly of claim 1, wherein said reciprocating positive displacement membrane pump pod comprises a curved rigid chamber wall, and said flexible membrane is attached to the rigid chamber wall, said flexible membrane and rigid chamber wall defining a pumping chamber.

4. The cassette assembly of claim 1, wherein said balancing pod comprises a curved rigid chamber wall, and said flexible membrane is attached to the rigid chamber wall so as to define two balance chambers.

5. The cassette assembly of claim 1, wherein said one or more valves is a membrane-based valve.

6. The cassette assembly of claim 5, wherein said membrane-based valve is a volcano valve.

7. The cassette assembly of claim 1, wherein each said one or more fluid conduits comprises a rigid hollow cylindrical member.

8. The cassette assembly of claim 7, wherein at least one of said fluid conduits includes a check valve.

9. The cassette assembly of claim 1, wherein a second reciprocating positive displacement membrane pump pod having an actuation port and a fluid port is positioned between the second cassette and the third cassette, the actuation port and the fluid port of the second membrane pump each communicating with a flow path in one of the second cassette and the third cassette.

10. A cassette assembly comprising:

a first cassette, a second cassette and a third cassette, the second cassette interposed between the first cassette and the third cassette, and spaced apart from the first cassette and the third cassette;

each cassette comprising a plurality of fluid flow paths and one or more valves, the second cassette being connected to the first and third cassettes by one or more fluid conduits;

a mixing pod having a mixing chamber, and an inlet port and an outlet port communicating with the mixing chamber, the mixing pod positioned between the first cassette and the second cassette, and the inlet port and the outlet port each communicating with a flow path in one of the first cassette and the second cassette;

a fluid flow balancing pod having a first balance chamber separated from a second balance chamber by a flexible membrane, the balancing pod having a first fluid port communicating with the first balance chamber and a second fluid port communicating with the second balance chamber, the balancing pod positioned between the second cassette and the third cassette, each said fluid port communicating with a flow path in one of the second cassette and the third cassette;

wherein

the mixing pod is configured to mix a first fluid with a second fluid to form a third fluid for delivery into the first balance chamber via the fluid port of the first balance chamber, and the balancing pod is configured to displace a substantially equal amount of a fourth fluid out of the second balance chamber via the fluid port of the second balance chamber.

11. The cassette assembly of claim 10, wherein the first fluid is a bicarbonate solution, the second fluid is an acid or salt solution, the third fluid is dialysate solution for flowing into a dialyzer, and the fourth fluid is dialysate solution returning from a dialyzer.

12. The cassette assembly of claim 10, wherein each said cassette comprises a top plate, a mid-plate and a bottom plate.

13. The cassette assembly of claim 10, wherein said balancing pod comprises a curved rigid chamber wall, and said flexible membrane is attached to the rigid chamber wall so as to define two balance chambers.

14. The cassette assembly of claim 10, wherein said one or more valves is a membrane-based valve.

15. The cassette assembly of claim 14, wherein said membrane-based valve is a volcano valve.

16. The cassette assembly of claim 10, wherein each said one or more fluid conduits comprises a rigid hollow cylindrical member.

17. The cassette assembly of claim 16, wherein at least one of said fluid conduits includes a check valve.

18. A cassette assembly comprising:

a first cassette, a second cassette and a third cassette, the second cassette interposed between the first cassette and the third cassette, and spaced apart from the first cassette and the third cassette;

each cassette comprising a plurality of fluid flow paths and one or more valves, the second cassette being connected to the first and third cassettes by one or more fluid conduits;

a reciprocating positive displacement membrane pump pod having an actuation chamber separated from a pumping chamber by a flexible membrane, the pump pod having an actuation port communicating with the actuation chamber and at least one fluid port communicating with the pumping chamber, the pump pod positioned between the first cassette and the second cassette, and the actuation port and the fluid port each communicating with a flow path in one of the first cassette and the second cassette;

a mixing pod having a mixing chamber, and an inlet port and an outlet port communicating with the mixing chamber, the mixing pod positioned between the first cassette and the second cassette, and the inlet port and the outlet port each communicating with a flow path in one of the first cassette and the second cassette;

a fluid flow balancing pod having a first balance chamber separated from a second balance chamber by a flexible membrane, the balancing pod having a first fluid port communicating with the first balance chamber and a second fluid port communicating with the second balance chamber, the balancing pod positioned between the second cassette and the third cassette, each said fluid port communicating with a flow path in one of the second cassette and the third cassette;

wherein

the mixing pod is configured to mix a first fluid with a second fluid to form a third fluid, the pump pod is configured to deliver the third fluid into the first balance chamber via the fluid port of the first balance chamber, and the balancing pod is configured to displace a substantially equal amount of a fourth fluid out of the second balance chamber via the fluid port of the second balance chamber.

19. The cassette assembly of claim 18, wherein the first fluid is a bicarbonate solution, the second fluid is an acid or salt solution, the third fluid is dialysate solution for flowing into a dialyzer, and the fourth fluid is dialysate solution returning from a dialyzer.

20. The cassette assembly of claim 18, wherein said reciprocating positive displacement membrane pump pod comprises a curved rigid chamber wall, and said flexible membrane is attached to the rigid chamber wall, said flexible membrane and rigid chamber wall defining a pumping chamber.

21. The cassette assembly of claim 18, wherein each said cassette comprises a top plate, a mid-plate and a bottom plate.

22. The cassette assembly of claim 18, wherein said balancing pod comprises a curved rigid chamber wall, and said flexible membrane is attached to the rigid chamber wall so as to define two balance chambers.

23. The cassette assembly of claim 18, wherein said one or more valves is a membrane-based valve.

24. The cassette assembly of claim 23, wherein said membrane-based valve is a volcano valve.

25. The cassette assembly of claim 18, wherein each said one or more fluid conduits comprises a rigid hollow cylindrical member.

26. The cassette assembly of claim 25, wherein at least one of said fluid conduits includes a check valve.