Method and device for intermittent occlusion of a vein draining the organ system

• US 8,500,623 B2
• Filed: 04/02/2012
• Issued: 08/06/2013
• Est. Priority Date: 11/30/2006
• Status: Active Grant

• Current Assignee: Miracor Medical Systems Gmbh
• Original Assignee: Miracor Medical Systems Gmbh
• Inventors: Mohl, Werner
• Primary Examiner(s): Layno, Carl H
• Application Number:
  US13/437,325
• Publication Number:
  US 20120190913A1
• Time in Patent Office: 491 Days
• Field of Search: 600/485, 600/486, 600/488, 600 16- 18, 606/158, 623/3.1
• US Class Current: 600/17
• CPC Class Codes: A61B 17/12 for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord specially adapted for vas deferens or fallopian tubes A61F6/20; materials for ligaturing blood vessels A61L17/00
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/1204 temporary occlusion
• CPC Class Codes: A61B 17/12136 Balloons
• CPC Class Codes: A61B 2017/00557 inflatable A61B2017/22051 takes precedence
• CPC Class Codes: A61B 5/02152 specially adapted for venous pressure
• CPC Class Codes: A61M 1/3613 Reperfusion, e.g. of the coronary vessels, e.g. retroperfusion
• CPC Class Codes: A61M 2025/0002 with a pressure sensor at the distal end
• CPC Class Codes: A61M 2025/1052 for temporarily occluding a vessel for isolating a sector
• CPC Class Codes: A61M 2205/3344 Measuring or controlling pressure at the body treatment site
• CPC Class Codes: A61M 25/10181 Means for forcing inflation fluid into the balloon
• CPC Class Codes: A61M 60/143 inside the coronary sinus, e.g. for pressure-controlled intermittent coronary sinus occlusion
• CPC Class Codes: A61M 60/268 the displacement member being flexible, e.g. membranes, diaphragms or bladders
• CPC Class Codes: A61M 60/427 the force acting on the blood contacting member being hydraulic or pneumatic
• CPC Class Codes: A61M 60/531 using blood pressure data, e.g. from blood pressure sensors
• CPC Class Codes: A61M 60/554 of blood pressure

Abstract

In a method for the intermittent occlusion of a vein draining the organ system, in which the vein is occluded by an occlusion device, the fluid pressure in the occluded vein is continuously measured and stored, the behavior of the fluid pressure is determined as a function of time, and the occlusion of the vein is triggered and/or released as a function of at least one characteristic value derived from the pressure measurements, pressure is applied during the occlusion in a pulsating manner. The device for the intermittent occlusion of a vein, including an occlusion device, a pressure measuring device for continuously measuring the fluid pressure in the occluded vein, and a memory for storing the fluid pressure behavior as a function of time, means are provided for applying a pulsating pressure in the occluded vein.

Claims

1. A device for intermittent occlusion of a coronary sinus, comprising:

a multi-lumen catheter having a distal end portion;

an occlusion device coupled to the distal end portion of the multi-lumen catheter and being in communication with a first lumen of the multi-lumen catheter, the occlusion device being adjustable between a non-occluding state and an occluding state that is configured to substantially occlude the coronary sinus,

a pressure measuring device for measuring fluid pressure in the coronary sinus when the occlusion device is in the occluded state,

a memory for storing fluid pressure behavior as a function of time, and

a vibratory device configured to apply a pulsating pressure in pressure waves in the coronary sinus when the occlusion device is in the occluded state, wherein the vibratory device is mounted to the multi-lumen catheter at a position at least partially distal of the occlusion device and is in communication with a second lumen of the multi-lumen catheter.

2. A device according to claim 1, wherein the vibratory device is configured to be driven to form the pressure waves according to a wave signal that is synchronized with one or more ECG signals.

3. A device according to claim 2, wherein the vibratory device is arranged in a cage that is configured to operate as a stent.

4. A device according to claim 2, further comprising a device controlling formation of said pressure waves, which is connected with signal lines for said one or more ECG signals.

5. A device according to claim 1, wherein the vibratory device is configured to apply the pulsating pressure in pressure waves at frequencies of between 50 and 250 per minute.

6. A device according to claim 5, wherein the frequencies are between 100 and 200 per minute.

7. A device according to claim 1, wherein the vibratory device comprises a pneumatically or hydraulically expandable hollow body or balloon.

8. A device according to claim 1, wherein the pressure measuring device is configured to measure fluid pressure in the occluded coronary sinus, and configured to measure pressure peaks introduced by the vibratory device.

9. A device according to claim 1, further comprising a device for controlling formation of said pressure waves, which is configured to generate pressure waves from a lower threshold value of a detected pressure increase after the coronary sinus is occluded, and configured to stop generation of pressure waves upon release of the occlusion of the coronary sinus.

10. A device according to claim 1, wherein the vibratory device is configured to be driven by at least one of pneumatic, hydraulic, and piezoelectric power.

11. A device for intermittent occlusion of a coronary sinus, comprising:

a multi-lumen catheter having a distal end portion;

an occlusion device coupled to the distal end portion of the multi-lumen catheter and being in communication with a first lumen of the multi-lumen catheter, the occlusion device being adjustable between a non-occluding state and an occluding state that is configured to substantially occlude the coronary sinus,

a pressure measuring device for measuring fluid pressure in the coronary sinus when the occlusion device is in the occluded state,

a memory for storing fluid pressure behavior as a function of time, and

means for applying a pulsating pressure in the coronary sinus when the occlusion device is in the occluded state in pressure waves according to a wave signal that is synchronized with one or more ECG signals, wherein the means for applying a pulsating pressure comprises an oscillating body, wherein the pulsating pressure means is attached to the multi-lumen catheter at a position at least partially distal of the occlusion device and is in communication with a second lumen of the multi-lumen catheter.

12. A device according to claim 11, wherein said oscillating body is arranged in a cage configured to operate as a stent.

13. A device according to claim 11, further comprising a device controlling formation of said pressure waves, which is connected with signal lines for said one or more ECG signals.

14. A device according to claim 11, wherein the pulsating pressure means is configured to apply the pulsating pressure in pressure waves at frequencies of between 50 and 250 per minute.

15. A device according to claim 14, wherein the frequencies are between 100 and 200 per minute.

16. A device according to claim 11, wherein the oscillating body comprises a pneumatically or hydraulically expandable hollow body or balloon.

17. A device according to claim 11, wherein the pressure measuring device is positioned and adapted to measure fluid pressure in an occluded coronary sinus, and to measure pressure peaks introduced by the oscillating body.

18. A device according to claim 11, further comprising a device for controlling formation of said pressure waves, which is configured to generate pressure waves from a lower threshold value of a detected pressure increase after an occlusion, and configured to stop generation of pressure waves upon release of the occlusion.

19. A device according to claim 11, wherein the oscillating body is coupled to the catheter at a position that is distal of the occlusion device, and the oscillating body is configured to form the pressure waves only when the occlusion device is in an occlusion state.

20. A device according to claim 11, wherein the means for applying a pulsating pressure is configured to be driven by at least one of pneumatic, hydraulic, and piezoelectric power.