Speeding cure rate of bioadhesives
First Claim
Patent Images
1. A method comprising:
- contacting at least one isocyanate-terminated component with a dilute solution comprising at least one amine at a concentration of from about 0.01 weight percent to about 0.5 weight percent of the solution at a temperature of from about 20°
C. to about 40°
C.; and
allowing the at least one isocyanate-terminated component and the at least one amine to react in situ thereby forming a cured biocompatible adhesive composition within from about 1 second to about 5 minutes after contact, wherein the at least one isocyanate-terminated component is of the formula;
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Abstract
The present disclosure provides compositions having reduced viscosity which may be used as adhesives or tissue sealants, and includes methods for speeding the cure rate of such compositions.
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Citations
13 Claims
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1. A method comprising:
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contacting at least one isocyanate-terminated component with a dilute solution comprising at least one amine at a concentration of from about 0.01 weight percent to about 0.5 weight percent of the solution at a temperature of from about 20°
C. to about 40°
C.; andallowing the at least one isocyanate-terminated component and the at least one amine to react in situ thereby forming a cured biocompatible adhesive composition within from about 1 second to about 5 minutes after contact, wherein the at least one isocyanate-terminated component is of the formula; - View Dependent Claims (2, 3, 4, 5, 6, 11)
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7. A method comprising:
contacting at least one isocyanate-terminated component of the formula; - View Dependent Claims (8, 9, 10, 12, 13)
Specification