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Multiple drug delivery from a balloon and a prosthesis

  • US 8,501,213 B2
  • Filed: 09/14/2012
  • Issued: 08/06/2013
  • Est. Priority Date: 03/19/2004
  • Status: Expired due to Fees
First Claim
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1. A method for treating vascular disease comprising:

  • providing a balloon having an outer surface and a coming disposed on at least a portion of the outer surface, the coating including an initial amount of a cytostatic agent selected from the group consisting of zotarolimus, everolimus, pimecrolimus, or a combination thereof, the coating being capable of maintaining a therapeutically effective amount of the cytostatic agent on the outer surface for delivery to a vessel wall;

    positioning the balloon at a lesion site along the vessel wail; and

    expanding the balloon for temporary contact of the outer surface with the vessel wall to deliver the therapeutically effective amount of the cytostatic agent to the vessel wall at the lesion site, wherein between about 4.9% to about 23% of the initial amount of the cytostatic agent remains disposed on the outer surface after delivery of the therapeutically effective amount of the cytostatic agent to the vessel wall.

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