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Injectable multimodal polymer depot compositions and uses thereof

  • US 8,501,215 B2
  • Filed: 07/28/2003
  • Issued: 08/06/2013
  • Est. Priority Date: 07/31/2002
  • Status: Expired due to Fees
First Claim
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1. An injectable depot composition comprising:

  • (a) a polymer matrix comprising a plurality of bioerodible, biocompatible lactic acid-based polymers, wherein a first of said plurality of polymers is a low molecular weight (LMW) polymer having a weight average molecular weight ranging from about 3000 to about 10,000 and a second is a high molecular weight (HMW) polymer having a weight average molecular weight of greater than about 30,000, the polymer matrix having a bimodal molecular weight distribution of the plurality of polymers;

    (b) a solvent having a miscibility in water of less than or equal to 7% at 25°

    C., in an amount effective to plasticize the plurality of polymers and form a gel therewith, wherein the solvent is a solvent selected from the group consisting of aromatic alcohols, esters of aromatic acids, aromatic ketones, and mixtures thereof; and

    (c) a beneficial agent dissolved or dispersed in the gel.

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