Nanotubes as mitochondrial uncouplers
First Claim
1. A method of reducing the effects of traumatic brain injury in an individual comprising:
- administering a therapeutically effective amount of nanotubes into the individual, wherein the nanotubes are self-rectifying nanotubes, having a length of less than 50 nm and a conductance such that the nanotubes conduct protons only when a proton gradient of about 120-220 mV is present.
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Abstract
A method of uncoupling mitochondria in a subject including administering nanotubes to the subject in a therapeutically effective amount, wherein the nanotubes are self-rectifying is provided. A method of decreasing reactive oxygen species and decreasing detrimental loading of Ca2+ into mitochondria is provided, including administering a pharmaceutically effective amount of nanotubes into the subject. A method of reducing weight, treating cancer, reducing the effects of traumatic brain injury, or reducing the effects of ageing, in a subject including administering a pharmaceutically effective amount of nanotubes into the subject is also provided.
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Citations
24 Claims
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1. A method of reducing the effects of traumatic brain injury in an individual comprising:
administering a therapeutically effective amount of nanotubes into the individual, wherein the nanotubes are self-rectifying nanotubes, having a length of less than 50 nm and a conductance such that the nanotubes conduct protons only when a proton gradient of about 120-220 mV is present. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method of reducing the effects spinal cord injury in an individual comprising:
- administering a therapeutically effective amount of nanotubes into the individual, wherein the nanotubes are self-rectifying nanotubes, having a length of less than 50 nm and a conductance such that the nanotubes conduct protons only when a proton gradient of about 120-220 mV is present.
- View Dependent Claims (10, 11, 12, 13, 14, 15, 16)
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17. A method of reducing the effects of stroke in an individual comprising:
- administering a therapeutically effective amount of nanotubes into the individual, wherein the nanotubes are self-rectifying nanotubes, having a length of less than 50 nm and a conductance such that the nanotubes conduct protons only when a proton gradient of about 120-220 mV is present.
- View Dependent Claims (18, 19, 20, 21, 22, 23, 24)
Specification