Detection of target analytes using particles and electrodes
First Claim
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1. A composition comprising:
- a) a magnetic particle comprising a first binding ligand that specifically binds a target analyte; and
b) a colloidal particle comprising;
i) a second binding ligand that specifically binds said target analyte; and
ii) a third binding ligand different from said second binding ligand,wherein said first and second binding ligands are antibodies, and said third binding ligand is a nucleic acid.
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Abstract
The invention relates to the use of particles comprising binding ligands and electron transfer moieties (ETMs). Upon binding of a target analyte, a particle and a reporter composition are associated and transported to an electrode surface. The ETMs are then detected, allowing the presence or absence of the target analyte to be determined.
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Citations
4 Claims
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1. A composition comprising:
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a) a magnetic particle comprising a first binding ligand that specifically binds a target analyte; and b) a colloidal particle comprising; i) a second binding ligand that specifically binds said target analyte; and ii) a third binding ligand different from said second binding ligand, wherein said first and second binding ligands are antibodies, and said third binding ligand is a nucleic acid. - View Dependent Claims (2, 3, 4)
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Specification