Single particle QCL-based mid-IR spectroscopy system with analysis of scattering
First Claim
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1. A system with scattering analysis, comprising:
- a handling system that presents a single particle, that has not been chemically conditioned for analysis, to at least one quantum cascade laser (QCL) source;
the at least one QCL laser source configured to deliver light to the single particle in order to induce resonant mid-infrared absorption in the particle or an analyte within the particle; and
a mid-infrared detection facility that detects a mid-infrared wavelength light scattered by the single particle,wherein an analysis of intensity versus at least one of wavelength and angle of the scattered mid-infrared wavelength light is used to determine analyte-specific structural and concentration information.
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Abstract
This disclosure concerns a system with scattering analysis including a handling system that presents a single particle to at least one quantum cascade laser (QCL) source. The QCL laser source is configured to deliver light to the single particle in order to induce resonant mid-infrared absorption in the particle or an analyte within the particle. A mid-infrared detection facility detects the mid-infrared wavelength light scattered by the single particle, wherein a wavelength and angle analysis of the scattered mid-IR wavelength light is used to determine analyte-specific structural and concentration information.
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20 Claims
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1. A system with scattering analysis, comprising:
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a handling system that presents a single particle, that has not been chemically conditioned for analysis, to at least one quantum cascade laser (QCL) source; the at least one QCL laser source configured to deliver light to the single particle in order to induce resonant mid-infrared absorption in the particle or an analyte within the particle; and a mid-infrared detection facility that detects a mid-infrared wavelength light scattered by the single particle, wherein an analysis of intensity versus at least one of wavelength and angle of the scattered mid-infrared wavelength light is used to determine analyte-specific structural and concentration information. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A system with scattering analysis, comprising:
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a handling system that presents a single particle to at least one quantum cascade laser (QCL) source; the at least one QCL source configured to deliver light to the single particle in order to induce resonant mid-infrared absorption in the particle or an analyte within the particle; and a mid-infrared detection facility that detects a mid-infrared wavelength light scattered by the single particle, wherein an analysis of intensity versus at least one of wavelength and angle of the scattered mid-infrared wavelength light is used to determine analyte-specific structural and concentration information, and wherein the at least one QCL source is configured to deliver light to a particle in a volume of a microfluidic handling system. - View Dependent Claims (11, 12, 13, 14)
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15. A system with scattering analysis, comprising:
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a handling system that presents a single cell to at least one quantum cascade laser (QCL) source; the at least one QCL source configured to deliver light to the single cell in order to induce resonant mid-infrared absorption in the particle or an analyte within the cell; and a mid-infrared detection facility that detects a mid-infrared wavelength light scattered by the single cell, wherein an analysis of intensity versus at least one of wavelength and angle of the scattered mid-infrared wavelength light is used to determine analyte-specific structural and concentration information, and wherein the cell remains viable after the analysis. - View Dependent Claims (16, 17, 18, 19, 20)
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Specification