Method and apparatus for coupling a channeled sample probe to tissue

• US 8,504,128 B2
• Filed: 04/24/2008
• Issued: 08/06/2013
• Est. Priority Date: 03/08/2002
• Status: Active Grant

• Current Assignee: GLT Acquisition Corporation
• Original Assignee: GLT Acquisition Corporation
• Inventors: Blank, Thomas B., Monfre, Stephen L., Hazen, Kevin H., Ruchti, Timothy L., Slawinski, Christopher, Brown, Sedar R.
• Primary Examiner(s): WINAKUR, ERIC FRANK
• Assistant Examiner(s): LIU, Chu Chuan (JJ)
• Application Number:
  US12/109,224
• Publication Number:
  US 20080319382A1
• Time in Patent Office: 1,930 Days
• Field of Search: 600/310, 600/316, 600/322, 600/323, 600/326, 600/333, 600/335, 600/336, 600/340, 600/344, 600/473, 600/476, 401/175, 401/263, 401/266
• US Class Current: 600/310
• CPC Class Codes: A61B 2562/146 for optical coupling
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: G01N 21/359 using near infrared light

Abstract

Sampling is controlled in order to enhance analyte concentration estimation derived from noninvasive sampling. More particularly, sampling is controlled using controlled fluid delivery to a region between a tip of a sample probe and a tissue measurement site. The controlled fluid delivery enhances coverage of a skin sample site with the thin layer of fluid. Delivery of contact fluid is controlled in terms of spatial delivery, volume, thickness, distribution, temperature, and/or pressure.

Claims

1. A sample probe configured to communicate with a non-invasive spectroscopic analyzer to determine an analyte property from a sample site of a body part, said sample probe comprising a sample probe tip having a microfluidic fluid delivery channel in a surface of said sample probe tip, said microfluidic fluid delivery channel forming a pathway for dispersion of a coupling fluid across the surface of said sample probe tip,

wherein said microfluidic fluid delivery channel comprises a first moat circumferentially surrounding an optic in said sample probe.

2. The sample probe of claim 1, further comprising a fluid delivery aperture in said sample probe tip and proximate to said first moat, wherein said coupling fluid is delivered from a reservoir via said fluid delivery aperture to said first moat.

3. The sample probe of claim 2, further comprising a second moat in the surface of said sample probe tip, said second moat circumferentially surrounding said first moat.

4. The sample probe of claim 2, further comprising means for maintaining temperature of said coupling fluid at about ninety to ninety-two degrees Fahrenheit prior to delivery of said coupling fluid.

5. The sample probe of claim 1, further comprising means for creating a negative pressure in said first moat during use of said analyzer.

6. The sample probe of claim 1, wherein said microfluidic fluid delivery channel further comprises at least one radially extending channel.

7. The sample probe of claim 1, wherein said microfluidic fluid delivery channel further comprises said first moat coupled to at least one radially extending channel.

8. The sample probe of claim 2, further comprising means for delivering said coupling fluid from said reservoir, via said fluid delivery aperature, to said microfluidic fluid delivery channel.

9. The sample probe of claim 8, in combination with said analyzer, wherein said analyzer comprises a processor configured to control said means for delivering.

10. The sample probe of claim 9, wherein said processor is configured to operate in accordance with a control signal from a sensor.

11. The sample probe of claim 10, wherein said sensor comprises any of:

an electrical contact sensor configured to sense proximate contact of said sample probe tip with the sample site, wherein upon proximate contact of said sample probe tip with the sample site, an electrical circuit is completed and said electrical contact sensor generates a signal indicative of completion of said electrical circuit; and

a pressure sensor configured to sense proximate contact of said sample probe tip with the sample site, wherein said pressure sensor comprises a film layer with air voids internally contained, wherein said pressure sensor is configured to generate a charge and corresponding voltage indicative of different capacitive charges measured as pressure is applied to said film layer.

12. The sample probe of claim 1, in combination with said analyzer, wherein said analyzer comprises a processor configured to control positioning of said sample probe tip relative to the sample site.

13. The sample probe of claim 12, wherein said processor is configured to operate in accordance with a control signal from a sensor.

14. The sample probe of claim 13, wherein said sensor comprises any of:

an electrical contact sensor configured to sense proximate contact of said sample probe tip with the sample site, wherein upon proximate contact of said sample probe tip with the sample site, an electrical circuit is completed and said electrical contact sensor generates a signal indicative of completion of said electrical circuit;

a pressure sensor configured to sense proximate contact of said sample probe tip with the sample site, wherein said pressure sensor comprises a film layer with air voids internally contained, wherein said pressure sensor is configured to generate a charge and corresponding voltage indicative of different capacitive charges measured as pressure is applied to said film layer; and

an optical sensor configured to sense proximate contact of said sample probe tip with the sample site using spectral responses from said analyzer at about 1450 nm or at about 1900 nm.

15. The sample probe of claim 1, wherein said analyte property comprises a glucose concentration, and said coupling fluid exhibits a viscosity of less than about 2.2 centistokes.

16. The sample probe of claim 1, wherein said analyte property comprises a glucose concentration, and said coupling fluid exhibits a refractive index of less than about 1.31.

17. The sample probe of claim 4, wherein said means for maintaining temperature comprises a heater.

18. The sample probe of claim 5, wherein said means for creating a negative pressure comprises a vacuum pump.

19. The sample probe of claim 8, wherein said means for delivering comprises a channel.

20. The sample probe of claim 8, wherein said means for delivering comprises a plurality of channels.

21. The sample probe of claim 8, wherein said means for delivering is integrated with said analyzer.

22. The sample probe of claim 8, wherein said means for delivering is removably operably coupled to said analyzer.

23. A method of delivering fluid to a sample site of a body part, the method comprising delivering a coupling fluid through a sample probe to a surface of a sample probe tip of said sample probe, the surface of said sample probe tip having a microfluidic fluid delivery channel forming a first pathway for dispersion of said coupling fluid across the surface of said sample probe tip,

wherein said sample probe is configured to communicate with a non-invasive spectroscopic analyzer to determine an analyte property from the sample site, and

wherein said microfluidic fluid delivery channel comprises a first moat circumferentially surrounding an optic in said sample probe.

24. The method of claim 23, further comprising delivering said coupling fluid from a reservoir to said first moat via a fluid delivery aperture in said sample probe tip, wherein said fluid delivery aperture is proximate to said first moat.

25. The method of claim 24, wherein the surface of said sample probe tip further has a second moat circumferentially surrounding said first moat, said second moat forming a second pathway for dispersion of said coupling fluid across the surface of said sample probe tip.

26. The sample probe of claim 23, wherein said microfluidic fluid delivery channel further comprises at least one radially extending channel.

27. The sample probe of claim 23, wherein said microfluidic fluid delivery channel further comprises said first moat coupled to at least one radially extending channel.