System and method for modulating action potential propagation during spinal cord stimulation

• US 8,504,160 B2
• Filed: 11/13/2009
• Issued: 08/06/2013
• Est. Priority Date: 11/14/2008
• Status: Expired due to Fees

• Current Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Inventors: Lee, Dongchul, Bradley, Kerry
• Primary Examiner(s): Koharski, Christopher D
• Assistant Examiner(s): VOORHEES, CATHERINE M
• Application Number:
  US12/618,563
• Publication Number:
  US 20100125313A1
• Time in Patent Office: 1,362 Days
• Field of Search: 607 45- 46, 607 66- 72
• US Class Current: 607/46
• CPC Class Codes: A61N 1/3605 Implantable neurostimulators for stimulating central or peripheral nerve system
• CPC Class Codes: A61N 1/36071 Pain

Abstract

A method and neurostimulator for providing therapy to a patient is provided. In one technique, an electrical pulsed waveform is conveyed between a caudal electrode and spinal cord tissue, thereby evoking action potentials that are orthodromically propagated along dorsal column fibers and evoking action potentials that are antidromically propagated along the DC fibers. Electrical energy is conveyed between a rostral electrode and the spinal cord tissue, thereby modulating times that the action potentials orthodromically propagated along the DC fibers arrive at the brain. In another technique, an electrical pulsed waveform is conveyed through a first electrode, thereby evoking action potentials that are propagated along a neural axon, and electrical energy is conveyed through the second electrode. The electrical energy has a frequency that is greater than a pulse rate of the electrical pulsed waveform, such that the action potentials propagated along the neural axon are blocked by the electrical energy.

Claims

1. A neurostimulator, comprising:

a plurality of electrical terminals configured for being electrically coupled to at least one electrode carrying stimulation lead;

analog output circuitry configured for conveying an electrical pulsed waveform to or from a first one of the electrical terminals simultaneous with conveying sinusoidal electrical energy to or from a second one of the electrical terminals in accordance with a set of stimulation parameters, wherein the electrical energy has a frequency that is greater than a pulse rate of the electrical pulsed waveform; and

control circuitry configured for generating the set of stimulation parameters.

2. The neurostimulator of claim 1, wherein the electrical pulsed waveform is capable of evoking action potentials that are propagated along a neural axon adjacent the stimulation lead, and the electrical energy is capable of blocking the action potentials propagated along the neural axon.

3. The neurostimulator of claim 1, wherein the pulse rate of the electrical pulsed waveform is within a range of 2 Hz-1200 Hz, and the frequency of the electrical energy is greater than 1200 Hz.

4. The neurostimulator of claim 3, wherein the frequency of the electrical energy is equal to or greater than 2000 Hz.

5. The neurostimulator of claim 1, further comprising a case containing the plurality of electrical terminals, analog output circuitry, and control circuitry to form an implantable neurostimulator.

6. The neurostimulator of claim 1, wherein the sinusoidal electrical energy is an electrical sinusoidally varying pulse.

7. A method of providing therapy to a patient using the neurostimulator of claim 1, comprising:

conveying the electrical pulsed waveform via the first electrical terminal between at least one caudal electrode and spinal cord tissue, thereby evoking action potentials that are orthodromically propagated along dorsal column (DC) neural fibers and evoking action potentials that are antidromically propagated along the DC neural fibers; and

conveying the electrical energy via the second electrical terminal between at least one rostral electrode and the spinal cord tissue, thereby modulating times that the action potentials orthodromically propagated along the DC neural fibers arrive at the brain of the patient.

8. The method of claim 7, wherein the action potentials antidromically propagated along the DC neural fibers provide therapy to the patient.

9. The method of claim 8, wherein the action potentials orthodromically propagated along the DC neural fibers create a sensation of paresthesia in the brain.

10. The method of claim 8, wherein the therapy is pain relief.

11. The method of claim 10, wherein the DC neural fibers innervate a region of pain experienced by the patient.

12. The method of claim 7, wherein the electrical energy conveyed between the at least one rostral electrode and the spinal cord tissue comprises a plurality of modulating electrical pulses.

13. The method of claim 12, wherein the modulating electrical pulses are anodic electrical pulses.

14. The method of claim 12, wherein each of the modulating electrical pulses sinusoidally varies.

15. The method of claim 14, wherein each of the modulating electrical pulses sinusoidally varies at a frequency greater than a pulse rate of the electrical pulsed waveform.

16. The method of claim 12, wherein the action potentials orthodromically propagated along the DC neural fibers and the modulating electrical pulses overlap each other at a point of modulation in the DC neural fibers.

17. The method of claim 7, wherein the action potentials orthodromically propagated along the DC neural fibers would otherwise create an undesirable sensation in the absence of the electrical energy conveyed between the at least one rostral electrode and the spinal cord tissue.

18. A method of providing therapy to a patient using the neurostimulator of claim 1 and first and second electrodes spaced along a first neural axon of the patient, comprising:

conveying an electrical pulsed waveform via the first terminal through the first electrode, thereby evoking action potentials that are propagated along the first neural axon; and

conveying electrical energy via the second terminal through the second electrode, wherein the electrical energy has a frequency that is greater than a pulse rate of the electrical pulsed waveform, such that the action potentials propagated along the first neural axon are blocked by the electrical energy.

19. The method of claim 18, wherein the action potentials are orthodromically propagated along the first neural axon.

20. The method of claim 19, wherein the first neural axon is a dorsal column (DC) neural fiber.

21. The method of claim 20, wherein the first electrode is a caudal electrode, and the second electrode is a rostral electrode.

22. The method of claim 18, wherein the electrical pulse waveform conveyed through the first electrode evokes action potentials in a second neural axon that are not blocked by the electrical energy conveyed through the second electrode.

23. The method of claim 22, wherein the first neural axon has a first depth in the spinal cord tissue, and the second neural axon has a second greater depth in the neural tissue.

24. The method of claim 23, wherein the first neural axon is a dorsal column (DC) neural fiber that innervates a first body region of the patient, and the second neural axon is a DC neural fiber that innervates a second different body region of the patient.

25. The method of claim 24, wherein the first body region is an anterior leg region of the patient, and the second body region is the lower back region of the patient.

26. The method of claim 18, wherein the electrical energy is anodic.

27. The method of claim 18, wherein the electrical energy is sinusoidal.

28. The method of claim 18, wherein the pulse rate of the electrical pulsed waveform is within a range of 2 Hz-1200 Hz, and the frequency of the electrical energy is greater than 1200 Hz.

29. The method of claim 18, wherein the frequency of the electrical energy is equal to or greater than 2000 Hz.