Optically-implemented microsurgery system and approach

• US 8,505,544 B2
• Filed: 05/31/2006
• Issued: 08/13/2013
• Est. Priority Date: 05/31/2005
• Status: Expired due to Fees

• Current Assignee: Board of Trustees of the Leland Stanford Junior University (Stanford Management Co.)
• Original Assignee: Board of Trustees of the Leland Stanford Junior University (Stanford Management Co.)
• Inventors: Zhang, Xiaojing, Solgaard, Olav
• Primary Examiner(s): ROANE, AARON F
• Application Number:
  US11/444,286
• Publication Number:
  US 20110160744A1
• Time in Patent Office: 2,631 Days
• Field of Search: 606/1, 606 41- 49, 128/898
• US Class Current: 128/898
• CPC Class Codes: C12M 35/00 Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion machines for extracting juice from animal or plant tissue by electroplasmolysis A23N1/006, processes employing electric or wave energy B01J19/08; treatment of microorganisms or enzymes with electrical or wave energy C12N13/00; methods for cell fusion C12N15/02; introduction of foreign genetic material C12N15/87
• CPC Class Codes: C12M 35/04 Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli

Abstract

According to an example embodiment of the present invention, a vibration-actuated microsurgical system includes an optical force detection arrangement having an optical encoding device configured to modulate an intensity of light in response to a displacement of a portion of the microsurgical system. Light sensing circuitry is configured to detect a force applied to the microsurgical system (e.g., and thereby to a sample) based on the intensity of light sensed from the optical encoding device. This detected force is used in controlling the application of the microsurgical system.

Claims

1. A method comprising:

illuminating a diffraction phase micrograting coupled to a vibration-actuated microsurgical tool and configured to change position, relative to a fixed scale micrograting and in response to movement of the vibration-actuated microsurgical tool;

sensing an intensity of light diffracted by the diffraction phase micrograting and the fixed scale micrograting; and

determining a force applied to the microsurgical tool based on the sensed intensity of light diffracted by the diffraction phase micrograting.

2. The method of claim 1, further including delivering an agent from a proximal end of the microsurgical tool to a distal end of the microsurgical tool.

3. The method of claim 1, further including reciprocally displacing the microsurgical tool substantially longitudinally.

4. The method of claim 1, further including reciprocally displacing the microsurgical tool substantially transversely.

5. The method of claim 1, wherein determining the force applied to the microsurgical tool comprises determining the force applied to the microsurgical tool in a range of about zero micronewtons to about 70 micronewtons.

6. A method for surgically treating a sample, the method comprising:

vibrationally-actuating and applying a probe tip to a sample;

illuminating a diffraction phase micrograting coupled to a vibration-actuated microsurgical tool and configured to change position, relative to a fixed scale micrograting and in response to movement of the vibration-actuated microsurgical tool;

sensing an intensity of light diffracted by the diffraction phase micrograting and the fixed scale micrograting;

determining a force applied to the microsurgical tool based on the sensed intensity of light diffracted by the diffraction phase micrograting; and

controlling the application of the probe tip to the sample as a function of the determined force.

7. The method of claim 6, wherein controlling the application of the probe tip to the sample as a function of the determined force includes

using the determined force to detect penetration of the sample, and

after detecting penetration, terminating the application of the probe tip to the sample.

8. The method of claim 7, further including, after detecting penetration, injecting a substance into the sample via the probe tip.

9. The method of claim 6, further including

generating a feedback signal characterizing the determined force applied to the microsurgical tool;

and

controlling the application of the probe tip to the sample as a function of the feedback signal.

10. The method of claim 6,

wherein vibrationally-actuating and applying a probe tip to the sample includes vibrationally-actuating and applying the probe tip to a plurality of similar samples at different combinations of vibration frequency and rate of application of the probe tip,

wherein determining a force applied to the microsurgical tool based on the intensity of light diffracted by the diffraction phase micrograting includes, for each sample, determining a force applied to the microsurgical tool to effect penetration of the sample,

further including selecting a combination of vibration frequency and rate of application of the probe tip as a function of the determined forces applied to the samples, and

further including calibrating the microsurgical tool to use the selected combination of vibration frequency and rate of application of the probe tip for use with analyzing additional similar samples.