Gas release devices for extracorporeal fluid circuits and related methods

• US 8,506,684 B2
• Filed: 12/15/2010
• Issued: 08/13/2013
• Est. Priority Date: 12/15/2010
• Status: Active Grant

• Current Assignee: Fresenius Medical Care Holdings Incorporated (Fresenius SE & Co. KGaA)
• Original Assignee: Fresenius Medical Care Holdings Incorporated (Fresenius SE & Co. KGaA)
• Inventors: Weaver, Colin, Crnkovich, Martin Joseph
• Primary Examiner(s): Smith, Duane
• Assistant Examiner(s): THEISEN, DOUGLAS J
• Application Number:
  US12/968,686
• Publication Number:
  US 20120152118A1
• Time in Patent Office: 972 Days
• Field of Search: 952/59, 952/60, 962/06, 962/19, 604/5.04
• US Class Current: 95/259
• CPC Class Codes: A61M 1/3622 with a cassette forming partially or totally the blood circuit
• CPC Class Codes: A61M 1/36222 Details related to the interface between cassette and machine
• CPC Class Codes: A61M 1/362261 at least one cassette surface or portion thereof being flexible, e.g. the cassette having a rigid base portion with preformed channels and being covered with a foil
• CPC Class Codes: A61M 1/362262 Details of incorporated reservoirs
• CPC Class Codes: A61M 1/3627 Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
• CPC Class Codes: A61M 2205/123 with incorporated reservoirs
• CPC Class Codes: B01D 19/0036 Flash degasification the other groups take precedence

Abstract

In one aspect, a gas release device for removing gas from a bodily liquid in extracorporeal circuitry is described. The device includes an elongate vertical portion and a flared portion that extends outwardly from the elongate vertical portion. The device also includes an inlet port for delivering a bodily liquid into the device, and an outlet port for evacuating the bodily liquid from the device. The inlet port is positioned below the elongate vertical portion and the outlet port is positioned below the flared portion such that bodily liquid traveling from the inlet toward the outlet is forced around the flared portion to cause air bubbles in the bodily liquid to be re-circulated back toward the inlet port.

Claims

1. A gas release device for removing gas from a bodily liquid in extracorporeal circuitry, the gas release device comprising:

an elongate vertical portion;

a flared portion extending outwardly from the elongate vertical portion;

an inlet port for delivering a bodily liquid into the gas release device; and

an outlet port for evacuating the bodily liquid from the gas release device,

wherein the inlet port is positioned below the elongate vertical portion and the outlet port is positioned below the flared portion such that bodily liquid traveling from the inlet port toward the outlet port is forced around the flared portion to cause gas bubbles in the bodily liquid to be re-circulated back toward the inlet port, and the elongate vertical portion has a height sufficient to maintain an interface between a first liquid in the gas release device and a second liquid in the gas release device when the first and second liquids are miscible and the second liquid is flowing through the gas release device.

2. The gas release device of claim 1, wherein the gas release device has a substantially flat geometry.

3. The gas release device of claim 1, wherein the gas release device has a substantially tubular geometry.

4. The gas release device of claim 1, wherein the elongate vertical portion has a height of about 2.54 inches to about 3.10 inches.

5. The gas release device of claim 4, wherein the elongate vertical portion has a height of 2.82 inches.

6. The gas release device of claim 1, wherein the elongate vertical portion has a hollow volume of about 0.70 cubic inches to about 1.33 cubic inches.

7. The gas release device of claim 1, wherein a first side of the flared portion extends outwardly from the elongate vertical portion at an angle of about 44°

to about 54°

relative to a centerline of the elongate vertical portion.

8. The gas release device of claim 7, wherein the first side of the flared portion extends outwardly from the elongate vertical portion at an angle of 49°

relative to the centerline of the elongate vertical portion.

9. The gas release device of claim 1, wherein a first side of the flared portion extends outwardly from the elongate vertical portion at an angle of about 27°

to about 33°

relative to a centerline of the elongate vertical portion.

10. The gas release device of claim 9, wherein the first side of the flared portion extends outwardly from the elongate vertical portion at an angle of 30°

relative to the centerline of the elongate vertical portion.

11. The gas release device of claim 1, wherein the gas release device comprises:

a main body, which defines the elongate vertical portion and the flared portion; and

a two port cap, which defines the inlet and outlet ports.

12. The gas release device of claim 1, wherein the inlet port is elevated above the outlet port with respect to the standard orientation of the gas release device.

13. The gas release device of claim 12, wherein the inlet port is elevated at a height of about 0.29 inches to about 0.35 inches above the outlet port.

14. The gas release device of claim 1, wherein a bottom wall of the gas release device extends at an angle of about 54°

to about 66°

relative to vertical, with respect to the standard orientation of the gas release device.

15. The gas release device of claim 14, wherein the bottom wall of the gas release device extends at an angle of 60°

relative to vertical, with respect to the standard orientation of the gas release device.

16. The gas release device of claim 1, further comprising a dam between the inlet port and the outlet port.

17. The gas release device of claim 1, further comprising a clot filter positioned in the gas release device, the clot filter positioned so that the liquid passes through the clot filter prior to passing through the outlet port.

18. The gas release device of claim 1, wherein the gas release device is incorporated as a component in a cassette-like integrated fluid circuit adapted to removably seat in a bodily liquid purification machine.

19. A method of removing gas from blood in extracorporeal circuitry, comprising:

passing a blood-compatible component through an inlet port of a gas release device, thereby filling the gas release device so that substantially no gas remains in the gas release device;

then

passing blood through the inlet port and into an elongate vertical portion of the gas release device until upward motion of the blood is impeded by gravity, thereby forming a liquid-liquid interface between the blood-compatible component and the blood; and

passing the blood along a flared portion of the gas release device toward an outlet port such that gas bubbles in the blood are directed back toward the inlet port to be released through the elongate vertical portion.

20. The method of claim 19, wherein passing the blood-compatible component through the inlet port includes passing saline through the inlet port.

21. The method of claim 19, further comprising:

forcing the blood over a dam after passing the blood through the inlet port; and

passing the blood out the outlet port after forcing the blood over the dam.

22. The method of claim 19, further comprising:

passing the blood through a clot filter; and

passing the blood through the outlet port after passing the blood through the clot filter.

23. The method of claim 19, wherein the inlet port of the gas release device is elevated relative to the outlet port of the gas release device.

24. A gas release device for removing gas from a bodily liquid in extracorporeal circuitry, the gas release device comprising:

a main body that defines an elongate vertical portion and a flared portion extending outwardly from the elongate vertical portion; and

a two port cap that defines an inlet port for delivering a bodily liquid into the gas release device and an outlet port for evacuating the bodily liquid from the gas release device,

wherein the inlet port is positioned below the elongate vertical portion and the outlet port is positioned below the flared portion such that bodily liquid traveling from the inlet port toward the outlet port is forced around the flared portion to cause gas bubbles in the bodily liquid to be re-circulated back toward the inlet port.

25. The gas release device of claim 24, wherein a first side of the flared portion extends outwardly from the elongate vertical portion at an angle of about 44°

to about 54°

relative to a centerline of the elongate vertical portion.

26. The gas release device of claim 24, wherein a first side of the flared portion extends outwardly from the elongate vertical portion at an angle of about 27°

to about 33°

relative to a centerline of the elongate vertical portion.