Process for in vivo treatment of specific biological targets in bodily fluids
First Claim
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1. A process for treating a stem cell comprising the steps of:
- introducing a fluid that includes at least one stem cell to an inlet of an assembly, the assembly comprising a flow chamber with a cross-sectional dimension less than 150 microns for conveying the fluid through the assembly, the flow chamber having a capture zone comprising a stem cell-specific binding agent;
permitting the fluid to pass through the flow chamber wherein the stem cell undergoes flux rolling along the stem cell-specific binding agent.
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Abstract
A process for treating biological targets in a fluid of a biological organism, including introducing a fluid comprising a biological target to an assembly comprising an inlet connected to receive the fluid and an outlet connected to pass the fluid from the assembly, wherein the assembly comprises a flow chamber for conveying a flow of the fluid, and a capture zone comprising a target-specific binding agent, wherein during flow of the fluid through the flow chamber, the biological target undergoes flux rolling along the target-specific binding agent.
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Citations
16 Claims
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1. A process for treating a stem cell comprising the steps of:
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introducing a fluid that includes at least one stem cell to an inlet of an assembly, the assembly comprising a flow chamber with a cross-sectional dimension less than 150 microns for conveying the fluid through the assembly, the flow chamber having a capture zone comprising a stem cell-specific binding agent; permitting the fluid to pass through the flow chamber wherein the stem cell undergoes flux rolling along the stem cell-specific binding agent.
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2. A process for treating a stem cell in the blood of an organism comprising the steps of:
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placing an assembly in fluid communication with a vein or artery of an organism, the assembly comprising a flow chamber with a cross-sectional dimension less than 150 microns for conveying a first portion of blood through the assembly, the flow chamber having a capture zone comprising a stem cell-specific binding agent; permitting blood to pass through the flow chamber, wherein during flow of the blood through the flow chamber, the stem cell undergoes flux rolling along the stem cell-specific binding agent. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A process for treating a cancer cell in the blood of an organism comprising the steps of:
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implanting an assembly in an organism such that the assembly is in fluid communication with a vein or artery of the organism, the assembly comprising a flow chamber with a cross-sectional dimension less than 150 microns for conveying a first portion of blood through the assembly, the flow chamber having a capture zone comprising a cancer cell-specific binding agent; permitting blood to pass through the flow chamber, wherein during flow of the blood through the flow chamber, the cancer cell undergoes flux rolling along the cancer cell-specific binding agent. - View Dependent Claims (13, 14, 15, 16)
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Specification