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Compositions and methods for promoting the generation of definitive endoderm

  • US 8,507,274 B2
  • Filed: 02/05/2010
  • Issued: 08/13/2013
  • Est. Priority Date: 02/06/2009
  • Status: Active Grant
First Claim
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1. A method of producing a definitive endoderm cell from a pluripotent stem cell comprising contacting a population of pluripotent stem cells with at least one compound of Formula (I) that activates TGF-β

  • signaling, thereby inducing the differentiation of at least one pluripotent stem cell into a definitive endoderm cell, wherein the definitive endoderm cell expresses Sox17, or HNF3B (FoxA2), or Sox17 and HNF3B (FoxA2) and wherein the compound of formula (I) is;

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