Cosmetic compositions comprising at least one peptide with at least one immobilized aromatic cycle

• US 8,507,649 B2
• Filed: 05/04/2007
• Issued: 08/13/2013
• Est. Priority Date: 05/05/2006
• Status: Active Grant

• Current Assignee: Sederma, Co.
• Original Assignee: Sederma, Co.
• Inventors: Lintner, Karl, Peschard, Olivier
• Primary Examiner(s): Lukton, David
• Application Number:
  US12/227,114
• Publication Number:
  US 20110045036A1
• Time in Patent Office: 2,293 Days
• Field of Search: 530/329, 514/21.8
• US Class Current: 530/329
• CPC Class Codes: A61K 38/08 Peptides having 5 to 11 amino acids A61K38/043 - A61K38/046 take precedence
• CPC Class Codes: A61K 8/64 Proteins; Peptides; Derivatives or degradation products thereof
• CPC Class Codes: A61P 17/16 Emollients or protectives, e.g. against radiation
• CPC Class Codes: A61Q 1/02 Preparations containing skin colorants, e.g. pigments preparations in powder form A61Q1/12
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 19/02 for chemically bleaching or whitening the skin
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations

Abstract

Topical cosmetic use as a whitening active ingredient of at least one peptide, comprising at least one blocked aromatic cycle and having the general formula (I): A-(Xa)m-Xc-(Xb)n-B. The invention also discloses a cosmetic composition comprising at least said peptide and a method of decreasing skin pigmentation, whitening or lightening human skin, comprising a topical application of said composition.

Claims

1. A method of decreasing skin pigmentation comprising applying to the skin of a human in need thereof an effective amount of a composition comprising a dermatologically acceptable carrier and at least one peptide of sequence A-His-Leu-Asp-Ile-Ile-Trp-B wherein

A is H, or an N-acyl group selected from the group consisting of elaidoyl, myristoyl, biotinyl, octanoyl, stearoyl, acetyl, and palmitoyl;

and

B is OR¹ or NR²R³, in which

R¹, R² and R³ are, independently of each other, H or an alkyl, aryl, aralkyl, acyl, alcohol, sulfonyl, sugar or alkoxy chain.

2. The method of claim 1, wherein said A is the N-acyl group selected from the group consisting of elaidoyl, myristoyl, biotinyl, octanoyl, stearoyl, acetyl, and palmitoyl, and said B is OR¹.

3. The method of claim 1, wherein said peptide is present at a concentration between 0.00001% (w/w) and 100% (w/w).

4. The method of claim 3, wherein said peptide is present at a concentration between 0.0001% (w/w) and 20% (w/w).

5. The method of claim 4, wherein said peptide is present at a concentration between 0.001% and 5% (w/w) by weight of the composition.

6. The method of claim 1 wherein the decrease in skin pigmentation is selected from the group consisting of lightening the complexion, attenuating senile lentigo, homogenizing skin color, reducing hyperpigmentation, reducing liver spots, reducing freckles and reducing dark complexion.

7. The method of claim 2 wherein the N-acyl group is acetyl or palmitoyl, and said B is OH.

8. The method of claim 7 wherein the N-acyl group is palmitoyl.

9. The method of claim 1 wherein the peptide is Pal-His-Leu-Asp-Ile-Ile-Trp-OH (SEQ ID NO:

28).

10. The method of claim 7 wherein the N-acyl group is acetyl.

11. The method of claim 2 wherein the N-acyl group is acetyl, and wherein the OR¹ is OH.