Solid forms of 3-(6-(1-(2,2-difluorobenzo[D][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid
First Claim
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1. 3-(6-(1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1) HCl Salt Form A characterized by a diffraction pattern substantially the same as that of FIG. 21.
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Abstract
The present invention relates to a substantially a solid form of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1, Solvate Form A and Compound 1, HCl Salt Form A), processes for making such forms, pharmaceutical compositions thereof, and methods of treatment therewith.
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5 Claims
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1. 3-(6-(1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1) HCl Salt Form A characterized by a diffraction pattern substantially the same as that of
FIG. 21 .
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2. 3-(6-(1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1) HCl Salt Form A characterized as a dimer as depicted in
FIG. 19 .
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3. 3-(6-(1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1) HCl Salt Form A characterized by the packing diagram depicted in
FIG. 20 .
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4. 3-(6-(1-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1) HCl Salt Form A having a P-1 space group, and the following unit cell dimensions:
- a=10.2702 (2) Å
, b=10.8782 (2) Å
, c=12.4821 (3) Å
, α
=67.0270 (10)°
, β
=66.1810 (10)°
, and γ
=72.4760 (10)°
.
- a=10.2702 (2) Å
Specification