Device and method for monitoring body fluid and electrolyte disorders
First Claim
1. A method of assessing changes in volume and osmolarity of body fluids in a body tissue, comprising:
- using a sensor;
emitting radiation at a tissue location using light emission optics configured to direct radiation of a given wavelength at the tissue location;
detecting radiation using light detection optics configured to receive radiation from the tissue location;
converting the detected radiation to an electrical signal indicative of the radiation received by the light detection optics;
using a processor;
processing the electrical signal to determine a water balance index and a tissue water concentration, wherein the water balance index comprises a difference between a water fraction in blood and a water fraction in extravascular tissue; and
analyzing in combination the water balance index and the tissue water concentration to assess the changes in volume and osmolarity of body fluids near the tissue location.
2 Assignments
0 Petitions
Accused Products
Abstract
Devices and methods for measuring body fluid-related metric using spectrophotometry that may be used to facilitate diagnosis and therapeutic interventions aimed at restoring body fluid balance. In one embodiment, the present invention provides a device for measuring a body-tissue water content metric as a fraction of the fat-free tissue content of a patient using optical spectrophotometry. The device includes a probe housing configured to be placed near a tissue location which is being monitored; light emission optics connected to the housing and configured to direct radiation at the tissue location; light detection optics connected to the housing and configured to receive radiation from the tissue location; and a processing device configured to process radiation from the light emission optics and the light detection optics to compute the metric where the metric includes a ratio of the water content of a portion of patient'"'"'s tissue in relation to the lean or fat-free content of a portion of patient'"'"'s tissue.
103 Citations
24 Claims
-
1. A method of assessing changes in volume and osmolarity of body fluids in a body tissue, comprising:
-
using a sensor; emitting radiation at a tissue location using light emission optics configured to direct radiation of a given wavelength at the tissue location; detecting radiation using light detection optics configured to receive radiation from the tissue location; converting the detected radiation to an electrical signal indicative of the radiation received by the light detection optics; using a processor; processing the electrical signal to determine a water balance index and a tissue water concentration, wherein the water balance index comprises a difference between a water fraction in blood and a water fraction in extravascular tissue; and analyzing in combination the water balance index and the tissue water concentration to assess the changes in volume and osmolarity of body fluids near the tissue location. - View Dependent Claims (2, 3, 4, 5, 6)
-
-
7. A method of processing changes in volume and osmolarity of body fluids in a body tissue, comprising:
-
using a processor; processing electrical signals indicative of radiation received from the body tissue to determine a water balance index and determine a tissue water concentration, wherein the water balance index comprises a difference between a water fraction in blood and a water fraction in extravascular tissue; and analyzing the water balance index and the tissue water concentration to assess the changes in volume and osmolarity of body fluids in the body tissue. - View Dependent Claims (8, 9, 10, 11, 12, 23)
-
-
13. A device for assessing changes in volume and osmolarity of body fluids in a body tissue, comprising:
-
means for emitting radiation at a tissue location using light emission optics configured to direct radiation of a given wavelength at the tissue location; means for detecting radiation using light detection optics configured to receive radiation from the tissue location; means for converting the detected radiation to an electrical signal indicative of the radiation received by the light detection optics; means for processing the electrical signal to determine a water balance index and a tissue water concentration, wherein the water balance index comprises a difference between a water fraction in blood and a water fraction in extravascular tissue; and means for analyzing in combination the water balance index and the tissue water concentration to assess the changes in volume and osmolarity of body fluids near the tissue location. - View Dependent Claims (14, 15, 16, 17, 18)
-
-
19. A device for processing changes in volume and osmolarity of body fluids in a body tissue, comprising:
-
means for processing electrical signals indicative of radiation received from the body tissue to determine a water balance index and determine a tissue water concentration, wherein the water balance index comprises a difference between a water fraction in blood and a water fraction in extravascular tissue; and means for analyzing the water balance index and the tissue water concentration to assess the changes in volume and osmolarity of body fluids in the body tissue. - View Dependent Claims (20, 21, 22, 24)
-
Specification