Sensor head for use with implantable devices
First Claim
1. A continuous glucose sensor system comprising:
- an implantable body comprising an electrode configured to measure a glucose concentration in a host, wherein the electrode is configured to generate a current output;
a membrane disposed over the electrode, the membrane comprising silicone and an enzyme configured to catalyze a reaction of glucose and oxygen from a biological fluid surrounding the membrane; and
sensor electronics operably connected to the electrode and configured to measure a current from the electrode;
wherein the continuous glucose sensor system is configured to maintain a 100% current output from the electrode in a fluid with an oxygen concentration of about 0.5 mg/L and a glucose concentration of 400 mg/dL, wherein the 100% current output corresponds to a current output of the system in a fluid with a glucose concentration of 400 mg/dL and an ambient oxygen concentration.
1 Assignment
0 Petitions
Accused Products
Abstract
The present invention provides a sensor head for use in an implantable device that measures the concentration of an analyte in a biological fluid which includes: a non-conductive body; a working electrode, a reference electrode and a counter electrode, wherein the electrodes pass through the non-conductive body forming an electrochemically reactive surface at one location on the body and forming an electronic connection at another location on the body, further wherein the electrochemically reactive surface of the counter electrode is greater than the surface area of the working electrode; and a multi-region membrane affixed to the nonconductive body and covering the working electrode, reference electrode and counter electrode. In addition, the present invention provides an implantable device including at least one of the sensor heads of the invention and methods of monitoring glucose levels in a host utilizing the implantable device of the invention.
1009 Citations
15 Claims
-
1. A continuous glucose sensor system comprising:
-
an implantable body comprising an electrode configured to measure a glucose concentration in a host, wherein the electrode is configured to generate a current output; a membrane disposed over the electrode, the membrane comprising silicone and an enzyme configured to catalyze a reaction of glucose and oxygen from a biological fluid surrounding the membrane; and sensor electronics operably connected to the electrode and configured to measure a current from the electrode; wherein the continuous glucose sensor system is configured to maintain a 100% current output from the electrode in a fluid with an oxygen concentration of about 0.5 mg/L and a glucose concentration of 400 mg/dL, wherein the 100% current output corresponds to a current output of the system in a fluid with a glucose concentration of 400 mg/dL and an ambient oxygen concentration. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
-
-
9. A continuous glucose sensor system comprising:
-
an implantable body comprising an electrode configured to measure a glucose concentration in a host, wherein the electrode is configured to generate a current output; a membrane disposed over the electrode, the membrane comprising silicone and an enzyme configured to catalyze a reaction of glucose and oxygen from a biological fluid surrounding the membrane; and sensor electronics operably connected to the electrode and configured to measure a current from the electrode; wherein the continuous glucose sensor system is configured to maintain a 100% current output from the electrode in a fluid with a glucose concentration of 400 mg/dL when an oxygen concentration in the fluid is decreased from about 7 mg/L to an oxygen concentration of about 0.5 mg/L. - View Dependent Claims (10)
-
-
11. A continuous glucose sensor system comprising:
-
an implantable body comprising an electrode configured to measure a glucose concentration in a host, wherein the electrode is configured to generate a current output; a membrane disposed over the electrode, the membrane comprising a first domain that comprises silicone and a second domain that comprises an enzyme configured to catalyze a reaction of glucose and oxygen from a biological fluid surrounding the membrane, wherein the first domain has a thickness of about 0.032 inches or less; and sensor electronics operably connected to the electrode and configured to measure a current from the electrode; wherein the continuous glucose sensor system is configured to maintain a 100% signal current output from the electrode in a fluid with an oxygen concentration of about 0.5 mg/L and a glucose concentration of 400 mg/dL, wherein the 100% current output corresponds to a current output of the system in a fluid with a glucose concentration of 400 mg/dL and an ambient oxygen concentration. - View Dependent Claims (12)
-
-
13. A continuous glucose sensor system comprising:
-
an implantable body comprising an electrode configured to measure a glucose concentration in a host, wherein the electrode is configured to generate a current output; a membrane disposed over the electrode, the membrane comprising a first domain that comprises silicone and a second domain that comprises an enzyme configured to catalyze a reaction of glucose and oxygen from a biological fluid surrounding the membrane, wherein the first domain has a thickness of about 0.032 inches or less; and sensor electronics operably connected to the electrode and configured to measure a current from the electrode; wherein the continuous glucose sensor system is configured to maintain a 100% current output from the electrode in a fluid with a glucose concentration of 400 mg/dL when an oxygen concentration in the fluid is decreased from an oxygen concentration of about 7 mg/L to an oxygen concentration of about 0.5 mg/L. - View Dependent Claims (14, 15)
-
Specification