Redundant connections to picafina probing device

• US 8,509,872 B2
• Filed: 11/14/2012
• Issued: 08/13/2013
• Est. Priority Date: 09/29/2008
• Status: Active Grant

• Current Assignee: Sergio Lara Pereira Monteiro
• Original Assignee: Chong I.L. Lee, Sergio Lara Pereira Monteiro
• Inventors: Lee, Chong Il, Monteiro, Sergio Lara Pereira
• Primary Examiner(s): Cohen, Lee S
• Assistant Examiner(s): Cardinal, Erin M
• Application Number:
  US13/676,944
• Publication Number:
  US 20130072778A1
• Time in Patent Office: 272 Days
• Field of Search: 600/374, 600/377, 600/378, 600/393, 600/509, 600/544, 600/545
• US Class Current: 600/377
• CPC Class Codes: A61B 5/0004 characterised by the type of physiological signal transmitted
• CPC Class Codes: A61B 5/05 Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves impedance plethysmography A61B5/0295; measuring movement of the entire body or parts thereof A61B5/11; detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof A61B5/24
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/6868 Brain
• CPC Class Codes: A61B 5/6869 Heart
• CPC Class Codes: A61B 5/6877 Nerve
• CPC Class Codes: A61N 1/0531 Brain cortex electrodes
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/36185 Selection of the electrode configuration
• CPC Class Codes: A61N 1/37235 Aspects of the external programmer
• CPC Class Codes: A61N 1/37247 User interfaces, e.g. input or presentation means
• CPC Class Codes: A61N 1/3752 Details of casing-lead connections
• CPC Class Codes: G01R 1/06744 Microprobes, i.e. having dimensions as IC details
• CPC Class Codes: G01R 1/06766 Input circuits therefor
• CPC Class Codes: G01R 1/07307 with individual probe elements, e.g. needles, cantilever beams or bump contacts, fixed in relation to each other, e.g. bed of nails fixture or probe card

Abstract

A picafina device that is an electrode for measurement of neuron electrical activity where the number of measurement points is very large, and methods of selecting a subset of available measuring electrodes on the surface of the device. The device can keep the selection for a predetermined length of time, or for an indefinite length of time, both under control of the researcher or the neurosurgeon. Selecting a different measuring pad, or a combination of pads, is equivalent to making measurement at a different location or on a nearby neuron. Several parallel measurements can be made, in which case correlations can be made between the firing of different neurons.

Claims

1. A device for measuring an electrical signal occurring in body cells of an animal comprising:

a picafina having a generally cylindrical device body with a proximal extremity, a distal extremity, an inner lumen and an outer surface;

a plurality of measuring electrode tips on the outer surface of the picafina in fixed relative positions at the distal extremity;

a first plurality of wires running inside the lumen wherein the first plurality of wires have wires comprising at least one element selected from the group consisting of;

electric power wires, binary information wires, and signal carrying wires;

a plurality of first on/off switches, each of the first on/off switches associated with one of the measuring electrode tips for selecting the associated measuring electrode tip;

a plurality of second on/off switches, each of the second on/off switches associated with one of the first plurality of wires running inside the lumen;

a device connector at the proximal extremity of the picafina to connect the first plurality of wires in the lumen to additional wires outside the picafina device body, the additional wires outside the picafina for connecting to at least one element selected from the group consisting of;

a measuring and/or recording instrument, an electric energy storage, and a control electronics;

wherein the measuring electrode tips are configured to measure the electrical signal values at the body cells next to the respective measuring electrode tips; and

a timer electronic circuit that controls the duration of the “

on”

time of at least one of the first or second on/off switches such that once one of the plurality of switches is turned “

on”

it is kept in the “

on”

state for a pre-determined time, after which the timer electronic circuit moves the switch to the “

off”

state.

2. The device of claim 1 further comprising a plurality of electrical amplifiers, each electrical amplifier between each one of the measuring electrode tips and the associated first on/off switch.

3. The device of claim 1 further comprising a means for connecting in parallel a subset of the plurality of measuring electrode tips to the first plurality of wires, the means capable of latching the on state of each of the first on/off switches.

4. The device of claim 3 further comprising a means for un-latching all of the first on/off switches.

5. The device of claim 1 further comprising:

an addressing means having bits to form a first address to uniquely identify each of the measuring electrode tips and to form a second address to uniquely identify each of the first plurality of wires; and

a plurality of first address decoders, wherein each of the first address decoders is for one of the measuring electrode tips and associated first on/off switch and each of the first address decoders having a unique digital address;

a plurality of second address decoders, wherein each of the second address decoders is for one of the first plurality of wires and associated second on/off switch and each second address decoder having a unique digital address;

wherein the first address asserted on the addressing means at the proximal extremity is compared to the unique digital address of the first address decoder, such that when the unique address of the first address decoder is equal to the first address asserted on the addressing means, the first address decoder causes that the associated first on/off switch to enter the “

on”

state to select one of the measuring electrode tips, and the second address asserted on the addressing means at the proximal extremity is compared to the unique digital address of the second address decoder, such that when the unique address of the second address decoder is equal to the second address asserted on the addressing means, the second address decoder causes the associated second on/off switch to enter the “

on”

state to select one of the first plurality of wires, thereby completing the electrical connection between the selected measuring electrode tip and the selected one of the first plurality of wires.

6. The device of claim 5 wherein the addressing means further comprises a plurality of addressing wires running parallel to the first plurality of wires inside the lumen.

7. The device of claim 5 wherein the addressing means further comprises a wireless telemetry circuit.

8. The device of claim 1 wherein the timer electronic circuit is further configured to control an on/off duty cycle.

9. The device of claim 8 wherein the duty cycle is between 1 and 100%.

10. The device of claim 1, further comprising:

a box housing the electric energy storage and the control electronics;

an electrical signal intensity measurement apparatus capable of measuring the electrical signal intensity of the electrical signal occurring in the body cells, wherein the plurality of measuring electrode tips are connected to the electrical signal intensity measurement apparatus;

wherein the first plurality of wires is a first wire group to connect the plurality of measurement electrode tips to at least one device selected from the group consisting of;

the electrical signal intensity measurement apparatus, the electric energy storage and the control electronics;

wherein the device connector is a first electrical connector, the first electrical connector being electrically connected to each of the first plurality of wires;

wherein the additional wires outside the picafina device body comprises a second wire group consisting of a second plurality of wires outside of the picafina, a third plurality of wires outside of the picafina, a fourth plurality of wires outside of the picafina and a fifth plurality of wires outside of the picafina;

the second plurality of wires outside of the picafina having proximal ends and distal ends, wherein the distal ends of the second plurality of wires are connected to the first electrical connector and the proximal ends of the second plurality of wires are connected to the electrical energy storage and the control electronics;

the third plurality of wires outside of the picafina having proximal ends and distal ends, wherein the distal ends of the third plurality of wires are connected to the first electrical connector and the proximal ends of the third plurality of wires are connected to the electrical signal intensity measuring apparatus;

a second electrical connector at the proximal extremity of the picafina, the second electrical connector being electrically connected to each of the first plurality of wires;

the fourth plurality of wires outside of the picafina having proximal ends and distal ends, wherein the distal ends of the fourth plurality of wires are connected to the second electrical connector and the proximal ends of the fourth plurality of wires are connected to the electrical energy storage and the control electronics;

the fifth plurality of wires outside of the picafina having proximal ends and distal ends, wherein the distal ends of the fifth plurality of wires are connected to the second electrical connector and the proximal ends of the fifth plurality of wires are connected to the electrical signal intensity measuring apparatus,

wherein the second electrical connector, the fourth plurality of wires and the fifth plurality of wires duplicate the first electrical connector, the second plurality of wires and the third plurality of wires to keep the electrical connection between the parts of the device when one of them breaks.

11. The picafina device of claim 10, where the cylindrical device body is configured to be implanted at a first location in said animal.

12. The device of claim 11, where the box housing the electric energy storage and control electronics is configured to be implanted at a second location in said animal.

13. The device of claim 11, where the box housing the electric energy storage and control electronics is external to the animal.

14. The device of claim 10, where the electrical signal intensity measuring apparatus to measure the signal intensity of the electrical signal occurring in the body cells resides in the box housing the electric energy storage and the control electronics.

15. The device of claim 10, where the electrical signal intensity measurement apparatus resides externally to the animal.

16. The device of claim 1, further comprising:

the measuring and/or recording instrument comprising an electrical signal intensity measuring apparatus, wherein the measuring electrode tips are connected to the electrical signal intensity measuring apparatus;

the additional wires outside the picafina comprising at least a second plurality of wires and a third plurality of wires external to the picafina,

a redundant connector at the proximal extremity of the picafina, connected to the first plurality of wires running inside the lumen, such that the redundant connector replicates all connections available in the device connector;

the third plurality of wires external to the picafina providing a connection redundant to the second plurality of wires, and connecting the redundant connector to the electrical signal intensity measuring apparatus;

wherein the device connector and second plurality of wires create a first connection between the first plurality of wires and the electrical signal intensity measuring apparatus, and the redundant connector and third plurality of wires create a second connection between the first plurality of wires and the electrical signal intensity measuring apparatus, such that the second connection provides a back-up electrical connection in case the first connection breaks during use.