Method and apparatus for adjustment of sequential biventricular pacing parameters

• US 8,509,891 B2
• Filed: 02/27/2012
• Issued: 08/13/2013
• Est. Priority Date: 01/28/2003
• Status: Expired due to Term

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Kramer, Andrew P., Ding, Jiang
• Primary Examiner(s): BOCKELMAN, MARK
• Application Number:
  US13/406,320
• Publication Number:
  US 20120158088A1
• Time in Patent Office: 533 Days
• Field of Search: 607/9, 607/15, 607/18, 607/23, 607/25, 607/30, 607/32, 607/39, 607/60
• US Class Current: 607/9
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36842 Multi-site stimulation in the same chamber
• CPC Class Codes: A61N 1/36843 Bi-ventricular stimulation

Abstract

A method and system are disclosed for setting the pacing parameters utilized by an implantable cardiac device in delivering cardiac resynchronization therapy. The system may, in different embodiments, be implemented in programming of the implantable device and an external programmer in communication therewith or in the programming of the implantable device by itself. The selection of the pacing parameters is based at least in part upon measurements of intrinsic cardiac conduction parameters. Among the pacing parameters which may be selected in this way are the atrio-ventricular delay interval used in atrial-tracking and AV sequential pacing modes and the biventricular offset interval.

Claims

1. An implantable cardiac rhythm management device, comprising:

sensing amplifiers for incorporating into atrial, right ventricular, and left ventricular sensing channels;

one or more pulse generators for incorporating into right and left ventricular pacing channels;

a controller for controlling the output of pacing pulses and receiving signals from the sensing amplifiers, wherein the controller is programmed to deliver a left ventricular pace and a right ventricular pace separated by a programmed biventricular offset interval in accordance with a demand pacing mode;

wherein the controller is programmed to generate signals from which the delay between right ventricular and left ventricular activation during an intrinsic beat, referred to as the Δ

_RL interval, may be measured; and

,

wherein the controller is programmed to compute an optimum biventricular offset interval in accordance with a formula which expresses the optimum biventricular offset interval as a function of the measured Δ

_RL interval.

2. The device of claim 1 wherein the controller is programmed to pace the ventricles within a programmable atrio-ventricular delay (AVD) interval after an atrial sense in an atrial-tracking mode or an atrial pace in an AV sequential pacing mode.

3. The device of claim 2 wherein the controller is programmed to measure at least one intrinsic atrio-ventricular delay interval from electrogram signals during an intrinsic beat and compute an optimum AVD interval in accordance with a formula which expresses the optimum AVD interval as a function of the measured intrinsic atrio-ventricular delay interval.

4. The device of claim 3 wherein the controller is programmed to measure right and left intrinsic atrio-ventricular delay intervals and a duration of ventricular depolarization from electrogram signals and wherein the formula for computing the optimum AVD interval includes a linear combination of the measured right and left intrinsic atrio-ventricular delays and the measured duration of ventricular depolarization.

5. The device of claim 3 wherein the controller is programmed such that a right intrinsic atrio-ventricular delay is measured as the interval between an atrial sense and a right ventricular sense designated as AV_R, a left intrinsic atrio-ventricular delay is measured as the interval between an atrial sense and a left ventricular sense designated as AV_L, and the formula for computing the AVD is:

AVD=k₁AV_R +k₂AV_L +k₃

where k₁, k₂, and k₃, are specified coefficients.

6. The device of claim 3 wherein the controller is programmed such that the right intrinsic atrio-ventricular delay is measured as the interval between an atrial sense and a right ventricular sense designated as AV_R, the left intrinsic atrio-ventricular delay is measured as the interval between an atrial sense and the start of left ventricular depolarization in an electrogram designated as AQ* _L, the duration of ventricular depolarization is measured as the interval from the start of left ventricular depolarization to the end of left ventricular depolarization in an electrogram designated as Q*S*, and the formula for computing the optimum AVD is:

AVD=k₁AV_R +k₂ AQ*_L +k₃Q*S* +k₄

where k₁, k₂, k₃, and k₄ are specified coefficients.

7. The device of claim 3 wherein the controller is programmed such that the intrinsic atrio-ventricular delay is measured as the interval between an atrial sense and a right ventricular sense designated as AV_R, a duration of ventricular depolarization is measured as the interval from the start of left ventricular depolarization to the end of left ventricular depolarization in an electrogram designated as Q*S*, and the formula for computing the optimum AVD is:

AVD=k₁AV_R +k₂Q*S* +k₃

where k₁, k₂, and k₃ are specified coefficients.

8. The device of claim 3 wherein the controller is programmed such that the specified coefficients defining a linear combination of the measured intrinsic atrio-ventricular delay interval and the measured duration of ventricular depolarization have been pre-derived from a linear regression analysis of clinical population data relating measured intrinsic atrio-ventricular delay intervals and measured durations of ventricular depolarization to an optimum AVD for delivering cardiac resynchronization therapy as determined by measurement of a cardiac function parameter.

9. The device of claim 3 wherein the controller is programmed to automatically set the programmed AVD interval in accordance with the computed optimum AVD interval.

10. The device of claim 3 wherein the controller is programmed to communicate the computed optimum AVD interval via a telemetry link.

11. The device of claim 1 wherein the controller is programmed to compute the optimum biventricular offset interval BVO as:

BVO=k₁Δ

_RL)+k₂

where k₁ and k₂ are specified coefficients.

12. The device of claim 11 wherein the specified coefficients defining the relationship between the optimum biventricular offset and the measured Δ

_RL interval have been pre-derived from a linear regression analysis of clinical population data relating measured Δ

_RL intervals to an optimum biventricular offset for delivering cardiac resynchronization therapy as determined by measurement of a cardiac function parameter.

13. The device of claim 12 wherein the formula for computing the optimum biventricular offset interval BVO is:

BVO=−

.333(Δ

_RL)−

20.

14. The device of claim 1 wherein the controller is programmed to automatically set the programmed biventricular offset interval in accordance with the computed optimum biventricular offset interval.

15. The device of claim 1 wherein the controller is programmed to communicate the computed optimum biventricular offset interval via a telemetry link.

16. The device of claim 1 wherein the measured Δ

_RL interval represents an average measurement taken over a plurality of intrinsic beats.

17. The device of claim 1 wherein the controller is programmed to modify the computed optimum biventricular offset interval in order to maintain a desired tachyarrhythmia rate threshold.

18. An implantable cardiac rhythm management device, comprising:

sensing amplifiers for incorporating into atrial, right ventricular, and left ventricular sensing channels;

one or more pulse generators for incorporating into right and left ventricular pacing channels;

a controller for controlling the output of pacing pulses and receiving electrogram signals from the sensing amplifiers, wherein the controller is programmed to deliver right and left ventricular pacing in accordance with a programmed pacing mode;

wherein the controller is programmed to measure at least one intrinsic atrio-ventricular delay (AVD) interval from electrogram signals during an intrinsic beat and compute an optimum AVD interval for delivering ventricular pacing in an atrial tracking or AV sequential pacing mode in accordance with a formula which expresses the optimum AVD interval as a function of the measured intrinsic AVD interval;

wherein the controller is programmed to measure the delay between right ventricular and left ventricular activation during an intrinsic beat, referred to as the Δ

_RL interval, and compute an optimum biventricular offset (BVO) interval in accordance with a formula which expresses the optimum BVO interval as a function of the measured Δ

_RL interval; and

,

wherein the controller is programmed to select between a left ventricle-only pacing mode, a right ventricle-only pacing mode, and a biventricular pacing mode based upon the computed optimum BVO and AVD intervals.

19. The device of claim 18, wherein the controller is programmed to select left ventricle-only pacing mode if the optimum BVO is smaller than a specified threshold T3 or if the difference between the optimum AVD and the optimum BVO is greater than the right intrinsic atrio-ventricular delay (AV_R) less a specified offset S1.

20. The device of claim 18, wherein the controller is programmed to select right ventricle-only pacing if the optimum BVO is larger than a specified threshold T4 or if the sum of the optimum AVD and BVO intervals is greater than a measured left intrinsic atrio-ventricular delay (AV_L).