Supraventricular stimulation to control ventricular rate

• US 8,509,893 B2
• Filed: 10/27/2010
• Issued: 08/13/2013
• Est. Priority Date: 10/27/2010
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Xiao, Yong-Fu, Sommer, John L., Brabec, Scott J., Zeng, Lepeng, Urban, Jon F.
• Primary Examiner(s): STOKLOSA, JOSEPH A
• Application Number:
  US12/913,354
• Publication Number:
  US 20120109237A1
• Time in Patent Office: 1,021 Days
• Field of Search: 607/9, 607/14
• US Class Current: 607/14
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions
• CPC Class Codes: A61N 1/36564 controlled by blood pressure
• CPC Class Codes: A61N 1/368 comprising more than one electrode co-operating with different heart regions A61N1/3622, A61N1/3627 take precedence

Abstract

Various techniques for delivering atrial pacing and supraventricular stimulation to achieve a desired ventricular rate and/or cardiac output are described. One example method described includes delivering a pacing signal configured to cause an atrial depolarization to a heart of a patient, wherein the atrial depolarization results in an associated refractory period during the cardiac cycle, and delivering a signal to a supraventricular portion of the heart of the patient subsequent to the atrial refractory period and during a ventricular refractory period of the cardiac cycle.

Claims

1. A method comprising:

delivering a pacing signal configured to cause an atrial depolarization to a heart of a patient having intact A-V conduction, wherein the atrial depolarization results in an associated refractory period during a cardiac cycle; and

delivering a signal to a supraventricular portion of the heart of the patient subsequent to the atrial refractory period and during a ventricular refractory period of the cardiac cycle.

2. The method of claim 1, wherein delivering the signal to the supraventricular portion of the heart comprises delivering the signal to at least one of an atrium, a sinoatrial node, or an atrioventricular node of the heart of the patient.

3. A method comprising:

delivering a pacing signal configured to cause an atrial depolarization to a heart of a patient, wherein the atrial depolarization results in an associated refractory period during a cardiac cycle; and

delivering a signal to a supraventricular portion of the heart of the patient subsequent to the atrial refractory period and during a ventricular refractory period of the cardiac cycle; and

further comprising detecting a ventricular depolarization of the cardiac cycle subsequent to the atrial depolarization, wherein the ventricular depolarization is associated with and precedes the ventricular refractory period, wherein delivering the signal to the supraventricular portion of the heart comprises delivering the signal to the supraventricular portion of the heart subsequent to detection of the ventricular depolarization.

4. The method of claim 3, wherein delivering the pacing signal comprises delivering the pacing signal at a pacing rate, wherein the pacing rate is selected based on a desired ventricular rate.

5. The method of claim 4, wherein delivering the signal to the supraventricular portion of the heart of the patient subsequent to the atrial refractory period and during the ventricular refractory period comprises delivering the signal at a determined time within the cardiac cycle.

6. The method of claim 5, wherein the determined time comprises an interval from at least one of the atrial pacing signal or the atrial depolarization.

7. The method of claim 5, wherein the determined time comprises an interval from the ventricular depolarization.

8. The method of claim 5, wherein the determined time comprises an interval that is determined based on a measured refractory period.

9. The method of claim 5, wherein delivering the signal at a determined time within the cardiac cycle comprises:

measuring a physiological parameter of the patient; and

determining a time within a predetermined window within the cardiac cycle to deliver the signal to the supraventricular portion of the heart based on the measured physiological parameter.

10. The method of claim 9, wherein the parameter comprises at least one of heart rate or blood pressure.

11. The method of claim 4, further comprising:

identifying a target value of a physiological parameter;

sensing the physiological parameter; and

titrating delivery of at least one of the pacing signal or the signal to the supraventricular portion of the heart to achieve the target value of the physiological parameter.

12. The method of claim 11, wherein the physiological parameter comprises at least one of heart rate or blood pressure.

13. The method of claim 4, wherein delivering the signal to the supraventricular portion of the heart comprises delivering a train of pulses to the supraventricular portion of the heart.

14. A system comprising:

a signal generator configured to deliver a pacing signal configured to cause an atrial depolarization to a heart of a patient, wherein the atrial depolarization results in an associated refractory period during a cardiac cycle, and deliver a signal to a supraventricular portion of the heart of the patient subsequent to the atrial refractory period and during a ventricular refractory period of the cardiac cycle; and

a processor configured to control the signal generator to deliver the pacing signal and the signal to the supraventricular portion of the heart; and

further comprising a sensing module configured to detect a ventricular depolarization of the cardiac cycle subsequent to the atrial depolarization, wherein the ventricular depolarization is associated with and precedes the ventricular refractory period, and wherein the signal generator delivers the signal to the supraventricular portion of the heart subsequent to detection of the ventricular depolarization.

15. The system of claim 14, further comprising a lead that comprises at least one electrode coupled to the signal generator, wherein the signal generator delivers the signal to the supraventricular portion of the heart via the at least one electrode of the lead.

16. The system of claim 14, wherein the processor controls the signal generator to deliver the pacing signal at a pacing rate, wherein the pacing rate is selected based on a desired ventricular rate.

17. The system of claim 16, wherein the processor controls the signal generator to deliver the signal to the supraventricular portion of the heart of the patient subsequent to the atrial refractory period and during the ventricular refractory period at a determined time within the cardiac cycle.

18. The system of claim 17, wherein the determined time comprises an interval from at least one of the atrial pacing signal or the atrial depolarization.

19. The system of claim 17, wherein the determined time window comprises an interval from the ventricular depolarization.

20. The system of claim 17, further comprising a sensing module that measures a physiological parameter of the patient, and wherein the processor determines a time within a predetermined window within the cardiac cycle to deliver the signal to the supraventricular portion of the heart based on the measured physiological parameter.

21. The system of claim 20, wherein the parameter comprises at least one of heart rate or blood pressure.

22. The system of claim 16, further comprising a sensing module configured to sense a physiological parameter, wherein the processor identifies a target value of the physiological parameter and controls the signal generator to titrate delivery of at least one of the pacing signal and the signal to the supraventricular portion of the heart to achieve the target value of the physiological parameter.

23. The system of claim 22, wherein the physiological parameter comprises at least one of heart rate or blood pressure.

24. The system of claim 16, further comprising an implantable medical device, wherein the implantable medical device comprises the signal generator and the processor.

25. The system of claim 24, wherein the implantable medical device comprises at least one of a pacemaker, cardioverter, or defibrillator.

26. The system of claim 16, wherein the processor controls the signal generator to deliver at least one of the pacing signal or the signal to the supraventricular portion of the heart as a train of pulses.

27. A method comprising:

delivering a pacing signal configured to cause an atrial depolarization to a heart of a patient having intact A-V conduction, wherein the atrial depolarization results in an associated refractory period during a cardiac cycle; and

delivering a signal to a supraventricular portion of the heart of the patient subsequent to the atrial refractory period and during a ventricular refractory period of the cardiac cycle, wherein delivering the pacing signal comprises delivering the pacing signal at a pacing rate, wherein the pacing rate is selected based on a desired ventricular rate.

28. The method of claim 27, wherein delivering the signal to the supraventricular portion of the heart comprises delivering the signal to at least one of an atrium, a sinoatrial node, or an atrioventricular node of the heart of the patient.