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Optimized method for LID biosensor resonance detection

  • US 8,510,082 B2
  • Filed: 06/02/2011
  • Issued: 08/13/2013
  • Est. Priority Date: 03/10/2006
  • Status: Expired due to Fees
First Claim
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1. An optical interrogation system for interrogating a label-independent biosensor, the optical interrogation system comprising:

  • a launch system that is arranged to emit an optical beam towards a biosensor;

    a receive system that is arranged to collect an optical beam from the biosensor and then to output a signal which is representative of the collected optical beam;

    a processor that is arranged to reduce pixelation oscillations in an optical resonance of the signal by oversampling at least a portion of the optical resonance, smoothing the optical resonance and calculating a resonance location or centroid that is based on the smoothed-oversampled optical resonance; and

    the processor is further arranged to monitor a biological event or a biochemical event on a top surface of the biosensor by sensing a shift between one calculated resonance location or centroid based on one smoothed-oversampled optical resonance and another calculated resonance location or centroid based on another smoothed-oversampled optical resonance.

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