Detection of the detachment of immobilized contrast agent in medical imaging applications

• US 8,512,249 B2
• Filed: 12/21/2007
• Issued: 08/20/2013
• Est. Priority Date: 12/21/2006
• Status: Active Grant

• Current Assignee: Bracco Suisse SA
• Original Assignee: Bracco International B.V. (Bracco SPA)
• Inventors: Frinking, Peter, Arditi, Marcel, Rognin, Nicolas, Messager, Tristan
• Primary Examiner(s): Le, Long V.
• Assistant Examiner(s): BOR, HELENE CATHERINE
• Application Number:
  US12/520,839
• Publication Number:
  US 20090304593A1
• Time in Patent Office: 2,069 Days
• Field of Search: 128/128, 128129-133, 600/458, 600/437
• US Class Current: 600/458
• CPC Class Codes: A61B 8/481 involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream analysis of echo signal exploiting properties of a contrast enhancer in devices for short-range imaging with acoustic waves G01S7/52039
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: G01S 7/52026 Extracting wanted echo signals Doppler systems G01S15/50; Doppler short range imaging systems G01S15/8979
• CPC Class Codes: G01S 7/52038 involving non-linear properties of the propagation medium or of the reflective target
• CPC Class Codes: G01S 7/52041 detecting modification of a contrast enhancer, e.g. detecting the destruction of a contrast agent by an acoustic wave, e.g. loss of correlation diagnostic techniques involving the use of contrast agents A61B8/481
• CPC Class Codes: G01S 7/52071 Multicolour displays; using colour coding; Optimising colour or information content in displays, e.g. parametric imaging
• CPC Class Codes: G01S 7/52074 Composite displays, e.g. split-screen displays; Combination of multiple images or of images and alphanumeric tabular information

Abstract

An input image includes a plurality of input values (i.e., pixel or voxel values), each input value indicative of a response to an interrogation signal of a corresponding location of a body-part, which possibly includes a contrast agent. At least one filtered image is generated from a plurality of selected input images and includes a filtered value for each of a plurality of selected ones of the locations. Each filtered value is indicative of the contrast agent leaving the selected location and is obtained by reducing a contribution of the contrast agent that is substantially stationary at the selected location along the selected input images for a period of time equal to or shorter than a first threshold and by reducing a contribution of the contrast agent that is substantially stationary for a period of time equal to or longer than a second higher threshold.

Claims

1. A method for imaging a body-part being perfused with a contrast agent, wherein the method includes the steps of:

providing a sequence of input images offering a digital representation over time of the body-part, each input image including a plurality of input values each one indicative of a response to an interrogation signal of a corresponding location of the body-part possibly including the contrast agent; and

generating at least one filtered image from a plurality of selected ones of the input images, wherein each filtered image includes a filtered value for each of a plurality of selected ones of the locations, the filtered value of each selected location being indicative of the contrast agent leaving the selected location after being substantially stationary at the selected location for a period of time comprised between a first non-zero threshold and a second threshold higher than the first threshold, the filtered value being obtained by;

reducing a contribution of the contrast agent being substantially stationary at the selected location along the selected input images for a period of time equal to or shorter than the first threshold; and

reducing a contribution of the contrast agent being substantially stationary at the selected location along the selected input images for a period of time equal to or longer than the second threshold.

2. The method according to claim 1, wherein the contrast agent is a target-specific contrast agent being capable of circulating within the patient and of being substantially immobilized on a biological target, each filtered value being indicative of the contrast agent detaching from the selected location after being temporarily immobilized at the selected location for a period of time comprised between the first threshold and the second threshold and/or moving slowly to remain at the selected location for a period of time comprised between the first threshold and the second threshold.

3. The method according to claim 1, wherein the step of providing the sequence of input images includes:

pre-processing the input images to reduce a contribution of the contrast agent being substantially stationary at each location along the selected input images for a period of time equal to or shorter than the first threshold,

and wherein the step of generating includes;

calculating each filtered value in each filtered image by cumulating a variation value indicative of a variation of a comparison value, said comparison value being based on a comparison set of input values for the selected location in a comparison set of the selected input images including a specific selected input image corresponding to the filtered image, with respect to a reference value, said reference value being equal to the input value for the selected location in one of the selected input images preceding the comparison set of selected input images in the sequence.

4. The method according to claim 1, wherein the step of generating includes:

calculating each filtered value in each filtered image by cumulating a variation value indicative of a variation of a comparison value, said comparison value being based on a comparison set of input values for the selected location in a comparison set of the selected input images including a specific selected input image corresponding to the filtered image, with respect to a reference value, said reference value being indicative of the lowest response of the selected location in a reference set of the selected input images preceding the comparison set of selected input images in the sequence.

5. The method according to claim 3, wherein the at least one filtered image consists of a further sequence of filtered images, the step of generating including:

calculating the filtered value in each filtered image by cumulating the variation value with the filtered value in one of the filtered images preceding the filtered image in the further sequence.

6. The method according to claim 3, further including:

displaying each filtered image substantially in real-time with an acquisition instant of the specific selected input image.

7. The method according to claim 3, wherein the comparison set of selected input images consists of the specific selected input image, the step of calculating each filtered value in each filtered image including:

setting the comparison value to the input value for the selected location in the specific selected input image.

8. The method according to claim 3, wherein the comparison set of selected input images consists of the specific selected input image and at least one of the selected input images preceding the specific selected input image in the sequence.

9. The method according to claim 8, wherein the step of calculating each filtered value in each filtered image includes:

temporally sub-sampling the comparison set of selected input images.

10. The method according to claim 8, wherein the step of calculating each filtered value in each filtered image includes:

setting the comparison value to one of the input values of the comparison set of selected input values being indicative of the highest response of the selected location.

11. The method according to claim 10, wherein each input value increases with the response of the corresponding location, the step of calculating each filtered value in each filtered image including:

setting the comparison value to the maximum of the comparison set of input values.

12. The method according to claim 3, wherein the step of calculating each filtered value in each filtered image includes:

setting the variation value to an absolute value of a difference between the comparison value and the reference value.

13. The method according to claim 3, wherein the step of calculating each filtered value in each filtered image includes:

setting the variation value to;

a delta value indicative of a decrease of the response of the selected location from the reference value to the comparison value when the response of the selected location decreases from the reference value to the comparison value, or

a null value otherwise.

14. The method according to claim 13, wherein each input value increases with the response of the corresponding location, the step of calculating each filtered value in each filtered image including:

setting the variation value to;

the reference value minus the comparison value when the comparison value is lower than the reference value, or

zero otherwise.

15. The method according to claim 1, wherein the body-part includes a tissue, the step of providing the sequence of input images including:

reducing a contribution of the tissue in the input images.

16. The method according to claim 1, wherein the step of generating includes:

selecting a background image in the sequence of input images, and

subtracting the background image from the selected input images.

17. The method according to claim 1, wherein the step of generating includes:

spatially sub-sampling the selected input images according to an estimated resolution thereof.

18. The method according to claim 1, wherein the step of providing the sequence of input images includes:

selecting a reference image in the sequence of input images and compensating a motion of each selected input image with respect to the reference image.

19. The method according to claim 1, wherein the step of generating includes:

linearizing the selected input images to make each input value thereof substantially proportional to a concentration of the contrast agent at the corresponding location.

20. The method according to claim 1, wherein the step of generating includes:

reducing each filtered image by resetting each filtered value in the filtered image not reaching a predefined threshold, and

creating an overlay image by overlaying each input image with a corresponding one of the reduced filtered images.

21. The method according to claim 20, wherein the step of generating includes:

representing, in each overlay image, each filtered value according to a first visual coding and each input value according to a second visual coding.

22. A computer program on a non-transitory storage medium configured for performing the method of claim 1 when the computer program is executed on a data processing system.

23. A medical imaging system including a computer program on a non-transitory storage medium configured to perform the steps of the method according to claim 1 when the computer program is executed on a data processing system.