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Automatic calibration of the sensitivity of a subject to a drug

  • US 8,512,273 B2
  • Filed: 02/28/2007
  • Issued: 08/20/2013
  • Est. Priority Date: 03/06/2006
  • Status: Active Grant
First Claim
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1. A method for calculating a current sensitivity of a subject to administration of an anesthetic drug during surgery, said method comprising the steps of:

  • changing an infusion rate of the drug by a calibration amount during surgery for calibration, in addition to a therapeutic infusion of the drug;

    detecting a change in an entropy signal in response to the infusion rate change; and

    determining a current sensitivity of the subject to the drug based on the change in the entropy signal wherein the current sensitivity has a value defined by a ratio comprising the change in the entropy signal and the change in the infusion rate.

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