Device for cutting a sample carrier

• US 8,512,637 B2
• Filed: 11/04/2011
• Issued: 08/20/2013
• Est. Priority Date: 05/06/2009
• Status: Active Grant

• Current Assignee: Biocartis NV (Biocartis Group NV)
• Original Assignee: Biocartis SA (Biocartis Group NV)
• Inventors: De Gier, Ronald, Steyvers, Ronaldus M. H., Zeijlstra, Harmina, Van De Wal, Marloes M. E. B., Visser, Astrid E.
• Primary Examiner(s): Warden, Jill
• Assistant Examiner(s): TAVARES, JULIE L
• Application Number:
  US13/289,534
• Publication Number:
  US 20120282616A1
• Time in Patent Office: 655 Days
• Field of Search: 422/68.1, 422/511, 738/646.3
• US Class Current: 422/68.1
• CPC Class Codes: A61B 10/0038 Devices for taking faeces samples; Faecal examination devices anal receptacles A61F5/451
• CPC Class Codes: A61B 10/0051 for taking saliva or sputum samples devices for receiving spittle A61J9/00
• CPC Class Codes: B01L 2200/025 Align devices or objects to ensure defined positions relative to each other
• CPC Class Codes: B01L 2300/045 whereby the whole cover is slidable
• CPC Class Codes: B01L 2300/046 Function or devices integrated in the closure
• CPC Class Codes: B01L 2300/0809 rectangular shaped
• CPC Class Codes: B01L 3/50 Containers for the purpose of retaining a material to be analysed, e.g. test tubes devices for taking samples of blood A61B5/15
• CPC Class Codes: B01L 3/5023 with a sample being transported to, and subsequently stored in an absorbent for analysis
• CPC Class Codes: Y10T 436/25 including sample preparation

Abstract

A device for receiving a sample carrier is provided. The device includes an opening for receiving part of the sample carrier and a cutter for removing a part of the sample carrier. The cutter is coupled to a lid, which is movable to allow the cutter to make an incision in the sample carrier and, at the same time, to close at least part of the opening left open after receipt of the sample carrier. The disclosure further relates to a system comprising such a device and a method for operating such a device.

Claims

1. A device for use in chemical analysis of sample material, the device comprising:

a housing comprised of a plurality of walls defining an inner volume, said plurality of walls including a first wall having an opening formed therein, wherein said opening is configured to receive at least part of a sample carrier having the sample material to be analyzed;

a cutting edge that functions as a cutter for making an incision in the sample carrier; and

a lid slidable in a moving path across the first wall from a first position to a second position that seals the opening, wherein when in the second position, at least part of the opening is closed by the lid, and wherein movement of the lid in the moving path forces the sample carrier into contact with the cutter wherein the cutting edge is formed on an edge of the lid or on a brim bounding the opening.

2. The device as claimed in claim 1, wherein the cutting edge is comprised of polycarbonate.

3. The device as claimed in claim 1, wherein the device further comprises a support structure along which the lid is slidable during at least part of the moving path.

4. The device as claimed in claim 3, wherein the support structure is positioned at least on a side of the lid.

5. The device as claimed in claim 1, wherein the cutting edge lies in a plane of the opening.

6. The device as claimed in claim 1, wherein the opening comprises a main opening part configured to receive a portion of the sample carrier and an auxiliary opening part adapted to retain the sample carrier in a desired position, the main opening part and the auxiliary opening part together forming a single opening.

7. The device as claimed in claim 6, wherein the auxiliary opening part is smaller than the main opening part.

8. The device as claimed in claim 6, wherein the auxiliary opening part retains the sample carrier in a press fit, and the main opening part holds the carrier from backlash.

9. The device as claimed in claim 6, wherein, when the lid is in the second position, the main opening part of said opening is closed by the lid.

10. The device as claimed in claim 6, wherein, when the lid is in the second position, the auxiliary opening part of said opening is not entirely covered by the lid.

11. The device as claimed in claim 1, wherein the lid is slidable in the moving path by a translation motion or a rotation motion.

12. The device as claimed in claim 1, further comprising a terminus for indicating the second position of the lid.

13. The device as claimed in claim 1, wherein the chemical analysis is a molecular diagnostics test.

14. The device as claimed in claim 1, wherein the device is a cartridge, the cartridge being insertable into an instrument for processing the cartridge.

15. The device as claimed in claim 1, wherein the lid is a generally planar element having a length, a width and a height, wherein each of the length and the width exceeds, at minimum, five times the height.

16. The device as claimed in claim 1, wherein the first wall includes a recessed portion, the opening being arranged in the recessed portion of the first wall, and the lid being movably arranged in the recessed portion.

17. The device as claimed in claim 16, wherein the recess has a height that corresponds to a height of the lid.

18. The device as claimed in claim 17, wherein the lid comprises a grip that assists manual movement of the lid.

19. The device as claimed in claim 16, wherein the lid has a planar dimension that is smaller than a planar dimension of the recessed portion of the wall.

20. The device as claimed in claim 16, wherein the lid has a planar bottom surface, the recessed portion of the first wall has a planar top surface, and the planar bottom surface of the lid is arranged on the planar top surface of the recessed portion of the first wall.

21. The device as claimed in claims 1, wherein the lid seals the opening by either closing the opening completely or closing a part of the opening that is left open by the sample carrier when received within the opening.

22. The device as claimed in claim 1, further comprising a retainer to retain the lid in the second position.

25. The device as claimed in claim 1, wherein the moving path is a straight line or a curved line.

23. A system comprising:

an instrument for use in the molecular analysis of a sample material;

a cartridge that is received in the instrument, wherein the cartridge comprises;

a housing comprised of a plurality of walls defining an inner volume, said plurality of walls including a first wall having an opening formed therein,

a cutting edge that function as a cutter, and

a lid slidable in a moving path across the first wall,

wherein the opening is configured to receive at least part of a sample carrier having the sample material to be analyzed,

wherein the cutting edge is formed by an edge of the movable lid so that movement of the lid from a first position in which the opening is open to receive the sample carrier to a second position in which the opening is at least partially closed forces the cutting edge into contact with the sample carrier.

24. A method for making an incision in a sample carrier comprising the steps of:

placing the sample carrier in an opening of a cartridge, said opening formed in a first wall of the cartridge; and

making the incision in the sample carrier by sliding a lid in a moving path across the first wall of the cartridge, from a first position in which the opening is open for receiving the sample carrier to a second position in which at least part of the opening is closed, wherein moving of the lid to the second position seals the opening.