Biocompatible coating of medical devices
First Claim
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1. An implantable medical device coated with a composition comprising:
- a) a coating matrix, andb) particles of one or more molecular sieves,wherein said coating matrix is a silicone matrix or a hydrophobic matrix,wherein said particles of said one or more molecular sieves comprise, within their pores, one or more bioactive agents,wherein the size of said pores of said one or more molecular sieve particles is selected to ensure controlled release rate of said bioactive agent,wherein said bioactive agent comprised within the pores of the molecular sieve is not an inorganic antimicrobial agent,wherein said implantable medical device comprises structural cavities on its inner and/or outer surface, andwherein the surface of said implantable medical device is not coated with said coating composition, with the exception of said structural cavities.
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Abstract
A coated implantable medical device is described, wherein the coating comprises a coating matrix and particles of one or more molecular sieves, preferably zeolite of zeogrid particles, optionally loaded with one or more bioactive agents. The coating matrix itself can function as a second drug-carrying interface. The coating comprising the molecular sieve material has an excellent biocompatibility and allows suitable drug delivery into the body of an animal, preferably a mammal and most preferably a human.
15 Citations
4 Claims
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1. An implantable medical device coated with a composition comprising:
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a) a coating matrix, and b) particles of one or more molecular sieves, wherein said coating matrix is a silicone matrix or a hydrophobic matrix, wherein said particles of said one or more molecular sieves comprise, within their pores, one or more bioactive agents, wherein the size of said pores of said one or more molecular sieve particles is selected to ensure controlled release rate of said bioactive agent, wherein said bioactive agent comprised within the pores of the molecular sieve is not an inorganic antimicrobial agent, wherein said implantable medical device comprises structural cavities on its inner and/or outer surface, and wherein the surface of said implantable medical device is not coated with said coating composition, with the exception of said structural cavities. - View Dependent Claims (2)
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3. An implantable medical device coated with a composition comprising:
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a) a coating matrix, and b) particles of one or more molecular sieves, wherein said coating matrix is a silicone matrix or a hydrophobic matrix, wherein said particles of said one or more molecular sieves comprise, within their pores, one or more bioactive agents, wherein the size of said pores of said one or more molecular sieve particles is selected to ensure controlled release rate of said bioactive agent, wherein said particles of said one of more molecular sieves are embedded within said coating matrix, wherein said bioactive agent comprised within the pores of the molecular sieve is not an inorganic antimicrobial agent, wherein said implantable medical device comprises structural cavities on its inner and/or outer surface, and wherein the surface of said implantable medical device is not coated with said coating composition, with the exception of said structural cavities. - View Dependent Claims (4)
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Specification