Perfluorocarbons for use in treating pruritus

• US 8,513,309 B2
• Filed: 09/30/2011
• Issued: 08/20/2013
• Est. Priority Date: 10/01/2010
• Status: Expired due to Fees

• Current Assignee: Tenax Therapeutics, Inc.
• Original Assignee: Oxygen Biotherapeutics, Inc.
• Inventors: Klein, Gerald
• Primary Examiner(s): HENLEY III, RAYMOND J
• Application Number:
  US13/250,682
• Publication Number:
  US 20120083510A1
• Time in Patent Office: 690 Days
• Field of Search: 514/672, 514/317, 514/743, 514/747, 514/757, 514/759, 514/761
• US Class Current: 514/672
• CPC Class Codes: A61K 31/02 Halogenated hydrocarbons
• CPC Class Codes: A61K 31/025 carbocyclic
• CPC Class Codes: A61K 31/131 acyclic
• CPC Class Codes: A61K 31/451 having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 17/04 Antipruritics
• CPC Class Codes: A61P 17/06 Antipsoriatics
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 37/08 Antiallergic agents antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14

Abstract

The subject application provides a method of treating pruritus comprising administering to the skin of a subject afflicted with pruritus an amount of a perfluorocarbon effective to treat the pruritus. The subject application also provides a method of alleviating a symptom of psoriasis comprising administering to the skin of a subject afflicted with psoriasis an amount of a perfluorocarbon effective to alleviate the symptom of psoriasis. The subject application also provides a perfluorocarbon composition for use in treating a subject afflicted with pruritus or psoriasis. The subject application further provides a pharmaceutical composition comprising an amount of a perfluorocarbon for use in treating pruritus or psoriasis.

Claims

1. A method of treating pruritus comprising administering to the skin of a subject afflicted with pruritus an amount of a perfluorocarbon effective to treat the pruritus.

2. The method of claim 1, wherein the pruritus is induced by histamine, a burn, an infection or hemodialysis.

3. The method of claim 1, wherein the pruritus is a symptom of an inflammatory skin condition, xerosis, an insect bite, a dermatological allergic response, allergic dermatitis, allergic contact dermatitis, photodermatitis, hand dermatitis, miliaria rubra, eczema, atopic dermatitis or contact dermatitis.

4. The method of claim 3, wherein the inflammatory skin condition is psoriasis or allergic vulvovaginitis.

5. The method of claim 1, wherein the pruritus is anal pruritus, uremic pruritus or aquagenic pruritus.

8. The method of claim 1, wherein the molecular formula of the perfluorocarbon consists 9-12 carbon atoms.

9. The method of claim 1, wherein the perfluorocarbon is perfluoro(tert-butylcyclohexane) perfluoro-n-butylcyclohexane, perfluorodecalin, trimethyl perfluorodecalin, perfluoroisopropyldecalin, perfluoro-tripropylamine, perfluorotributylamine, perfluoro-methylcyclohexylpiperidine, perfluoro-octylbromide, perfluoro-decylbromide, perfluoro-dichlorooctane, perfluorohexane, dodecafluoropentane, or a mixture thereof.

10. The method of claim 9, wherein the perfluorocarbon is perfluoro(tert-butylcyclohexane) or perfluoro-n-butylcyclohexane.

11. The method of claim 1, wherein the perfluorocarbon is in a perfluorocarbon gel or emulsion.

12. The method of claim 1, wherein the subject is afflicted with edema, erythema or erythematous lesion.

13. The method of claim 1, wherein the administration of the perfluorocarbon reduces subject-perceived itching.

14. The method of claim 1, wherein the administration of the perfluorocarbon relieves the subject'"'"'s pruritus for 3 hours or more.

15. The method of claim 1, wherein the administration of the perfluorocarbon relieves the subject'"'"'s pruritus within 1 minute of the administration.

16. The method of claim 1, wherein the subject is human.

6. A method of alleviating a symptom of psoriasis comprising administering to the skin of a subject afflicted with psoriasis an amount of a perfluorocarbon effective to alleviate the symptom of psoriasis.

7. The method of claim 6, wherein the symptom is pruritus.

17. The method of claim 6, wherein the perfluorocarbon is perfluoro(tert-butylcyclohexane) or perfluoro-n-butylcyclohexane.

18. The method of claim 6, wherein the perfluorocarbon is in a perfluorocarbon gel or emulsion.

19. The method of claim 7, wherein the administration of the perfluorocarbon relieves the subject'"'"'s pruritus for 3 hours or more.

20. The method of claim 7, wherein the administration of the perfluorocarbon relieves the subject'"'"'s pruritus within 1 minute of the administration.