Method for controlling a photometric measuring unit of a measuring device for obtaining and examining a bodily fluid sample and measuring system

• US 8,514,397 B2
• Filed: 03/14/2012
• Issued: 08/20/2013
• Est. Priority Date: 09/30/2009
• Status: Active Grant

• Current Assignee: Roche Diabetes Care Inc. (Roche Holding AG)
• Original Assignee: Roche Diagnostics Operations Incorporated (Roche Holding AG)
• Inventors: Wehowski, Frederic, Harttig, Herbert, Hoenes, Joachim
• Primary Examiner(s): Punnoose, Roy M
• Application Number:
  US13/419,533
• Publication Number:
  US 20120229810A1
• Time in Patent Office: 524 Days
• Field of Search: 356/39, 356/436, 422/82.05, 422/82.09
• US Class Current: 356/436
• CPC Class Codes: G01N 21/8483 Investigating reagent band test-element handling not specific to a test method G01N33/4875; analytical elements specific to chemical analysis of biological material G01N33/52; autometer with reagent band G01N35/04

Abstract

There is disclosed a method for controlling a photometric measuring unit of a measuring device for a bodily fluid sample, wherein a test field partially wetted by a bodily fluid sample is illuminated and light from a measuring area that covers a portion of the test field of the measuring unit is fed to a detector of the measuring unit, and the measuring area is displaced relative to the test field toward a partial surface wetted by the fluid sample and past the partial surface. The intensity of a detector signal is detected during the displacement, an extreme value in the course of the detector signal is determined, the measuring area is brought back to the position in which an extreme detector signal was previously measured, and the position of the measuring area in which the detector signal is extreme is used for a photometric determination of concentration.

Claims

1. A method for controlling a photometric measuring unit of a measuring device for examining a human or animal bodily fluid sample obtained by way of lancing, wherein:

a test field partially wetted by a bodily fluid sample is illuminated and light from a measuring area that covers a portion of the test field is fed to a detector of the measuring unit;

the measuring area is displaced relative to the test field toward a partial surface wetted by the bodily fluid sample and past the partial surface;

during the displacement, the intensity of a detector signal is measured and an extreme value in the course of the detector signal is determined;

the measuring area is returned to a position in which the extreme value of the detector signal was previously measured; and

the position of the measuring area in which the extreme value of the detector signal was measured is used for a photometric determination of analyte concentration.

2. The method according to claim 1, wherein the measuring area is positioned on the wetted partial surface of the test field by displacing the measuring area into the position in which the extreme value of the detector signal was previously measured, and then a photometric measurement is carried out to determine analyte concentration.

3. The method according to claim 1, wherein the measuring area is moved back and forth periodically on the test field such that the measuring area periodically passes over the wetted partial surface and a periodic detector signal is generated, wherein the photometric determination of analyte concentration is carried out by evaluating the intensity of the detector signal at the extreme value.

4. The method according to claim 2, wherein in order to determine the extreme value of the detector signal, the test field is illuminated with light having a spectral distribution that differs from a spectral distribution used for the photometric measurement to determine the analyte concentration.

5. The method according to claim 4, wherein a detector signal that was generated by light having the spectral distribution used to adjust the measuring unit is used to correct a measuring signal that was generated by light having the spectral distribution used for the photometric measurement.

6. The method according to claim 1, wherein the measuring area is displaced by moving a component of the measuring unit.

7. The method according to claim 1, wherein the measuring area is displaced by moving a carrier of the measuring unit which carries the detector and at least one light source.

8. The method according to claim 1, wherein the measuring area is displaced by moving the test field.

9. The method according to claim 1, wherein the measuring area is displaced in one direction by moving the test field, and is displaced in another direction by moving a component of the measuring unit.

10. The method according to claim 1, wherein the measuring unit performs a remission measurement.

11. The method according to claim 1, wherein the course of the detector signal measured during displacement of the measuring area is evaluated to determine whether the wetting is sufficient for a determination of concentration.

12. A measuring system for the photometric determination of an analyte concentration in a bodily fluid sample, comprising:

test fields having detection reagents which, upon contact with bodily fluid, induce a detection reaction which can be evaluated photometrically; and

a measuring device for measuring, by way of a test field, the analyte concentration in a bodily fluid sample obtained from a lanced site, wherein the measuring device includes a measuring unit for performing a photometric measurement of a color change of a test field, wherein the measuring unit has a light source and a detector, and the measuring unit defines a beam path for light from the light source to the detector, wherein the beam path limits the sensitivity of the detector to a partial region of a test field fed to the measuring unit, the test field partial region from which the beam path directs light to the detector is adjustable using at least one actuator, the actuator is controlled by a control unit which is operable to evaluate a detector signal and use an actuator setting at which the detector signal is extreme for a photometric determination of the analyte concentration.

13. The measuring system according to claim 12, wherein the lancing elements comprise a capillary channel that brings about the wetting of an elongated partial surface of a test field.

14. The measuring system according to claim 12, wherein the measuring unit comprises a plurality of light sources which are switched on in alternation by the control unit.

15. The measuring system according to claim 12, wherein the measuring unit comprises, in addition to the detector having the detector signal which is used for the adjustment of said measuring unit and for the subsequent photometric determination of concentration on a bodily fluid sample, a further detector for performing a reference measurement on an unwetted partial surface of the test field.