Analyte monitoring
First Claim
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1. An analyte sensor, comprising:
- a working electrode comprising a sensing layer disposed thereon, wherein the sensing layer comprises an analyte responsive enzyme;
a membrane disposed over at least a portion of the sensing layer comprising an antiglycolytic agent or precursor thereof; and
a counter electrode;
wherein the antiglycolytic agent or precursor thereof is glyceraldehyde, mannose, glucosamine, mannoheptulose, sorbose-6-phosphate, trehalose-6-phosphate, or trehalose-6-phosphate synthase.
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Abstract
Devices and methods for determining the concentration of an analyte are provided. Embodiments of the subject devices include analyte monitoring systems that include an analyte sensor capable of providing clinically accurate analyte data without a substantial time delay after operably positioning the sensor in a patient. Embodiments of the subject methods include operably positioning an analyte sensor in a patient and obtaining clinically accurate analyte data without a substantial time delay after the positioning. Also provided are systems and kits for use in analyte monitoring.
210 Citations
14 Claims
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1. An analyte sensor, comprising:
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a working electrode comprising a sensing layer disposed thereon, wherein the sensing layer comprises an analyte responsive enzyme; a membrane disposed over at least a portion of the sensing layer comprising an antiglycolytic agent or precursor thereof; and a counter electrode; wherein the antiglycolytic agent or precursor thereof is glyceraldehyde, mannose, glucosamine, mannoheptulose, sorbose-6-phosphate, trehalose-6-phosphate, or trehalose-6-phosphate synthase. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method for determining the concentration of an analyte, the method comprising:
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contacting an antiglycolytic agent or precursor thereof to an analyte determination site, wherein the antiglycolytic agent or precursor thereof is glyceraldehyde, mannose, glucosamine, mannoheptulose, sorbose-6-phosphate, or trehalose-6-phosphate; positioning at least a portion of an analyte sensor at the site in a subcutaneous space, wherein the analyte sensor comprises; a working electrode comprising a sensing layer disposed proximate thereto, wherein the sensing layer comprises an analyte responsive enzyme; a membrane disposed over at least a portion of the sensing layer; and a counter electrode; and determining the concentration of an analyte with the sensor. - View Dependent Claims (11)
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12. A glucose monitoring device, the device comprising:
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a glucose sensor comprising; a working electrode comprising a sensing layer disposed thereon, wherein the sensing layer comprises an analyte responsive enzyme; a membrane disposed over at least a portion of the sensing layer; and a counter electrode; wherein said glucose sensor is capable of providing clinically accurate analyte levels immediately following positioning of at least a portion of the sensor in a patient. - View Dependent Claims (13, 14)
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Specification