Analyte monitoring

• US 8,515,518 B2
• Filed: 12/28/2005
• Issued: 08/20/2013
• Est. Priority Date: 12/28/2005
• Status: Active Grant

• Current Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Inventors: Ouyang, Tianmei, Liu, Zenghe, Cho, Hyun, Feldman, Benjamin J.
• Primary Examiner(s): Mallari, Patricia
• Assistant Examiner(s): JANG, CHRISTIAN YONGKYUN
• Application Number:
  US11/322,165
• Publication Number:
  US 20070149875A1
• Time in Patent Office: 2,792 Days
• Field of Search: 600/365, 600/345, 600/347
• US Class Current: 600/347
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors

Abstract

Devices and methods for determining the concentration of an analyte are provided. Embodiments of the subject devices include analyte monitoring systems that include an analyte sensor capable of providing clinically accurate analyte data without a substantial time delay after operably positioning the sensor in a patient. Embodiments of the subject methods include operably positioning an analyte sensor in a patient and obtaining clinically accurate analyte data without a substantial time delay after the positioning. Also provided are systems and kits for use in analyte monitoring.

Claims

1. An analyte sensor, comprising:

a working electrode comprising a sensing layer disposed thereon, wherein the sensing layer comprises an analyte responsive enzyme;

a membrane disposed over at least a portion of the sensing layer comprising an antiglycolytic agent or precursor thereof; and

a counter electrode;

wherein the antiglycolytic agent or precursor thereof is glyceraldehyde, mannose, glucosamine, mannoheptulose, sorbose-6-phosphate, trehalose-6-phosphate, or trehalose-6-phosphate synthase.

2. The sensor of claim 1, wherein the antiglycolytic agent or precursor thereof is the antiglycolytic agent glyceraldehyde and the glyceraldehyde is present in an amount that ranges from about 1 microgram to about 1 milligram.

3. The sensor of claim 1, wherein the antiglycolytic agent or precursor thereof is coated on a surface of the membrane.

4. The sensor of claim 1, wherein the antiglycolytic agent or precursor thereof is incorporated into the membrane.

5. The sensor of claim 1, wherein the antiglycolytic agent or precursor thereof comprises a time-release formulation.

6. The sensor of claim 1, wherein the antiglycolytic agent or precursor thereof comprises the antiglycolytic agent precursor and the antiglycolytic agent precursor is trehalose-6-phosphate synthase.

7. The sensor of claim 1, wherein the analyte responsive enzyme is a glucose responsive enzyme.

8. The sensor of claim 1, wherein the analyte sensor is an in vivo analyte sensor.

9. The sensor of claim 1, wherein the working electrode is configured for positioning at least a portion thereof subcutaneously.

10. A method for determining the concentration of an analyte, the method comprising:

contacting an antiglycolytic agent or precursor thereof to an analyte determination site, wherein the antiglycolytic agent or precursor thereof is glyceraldehyde, mannose, glucosamine, mannoheptulose, sorbose-6-phosphate, or trehalose-6-phosphate;

positioning at least a portion of an analyte sensor at the site in a subcutaneous space, wherein the analyte sensor comprises;

a working electrode comprising a sensing layer disposed proximate thereto, wherein the sensing layer comprises an analyte responsive enzyme;

a membrane disposed over at least a portion of the sensing layer; and

a counter electrode; and

determining the concentration of an analyte with the sensor.

11. The method of claim 10, wherein the antiglycolytic agent or precursor thereof is the antiglycolytic agent glyceraldehyde and the glyceraldehyde is present in an amount that ranges from about 1 microgram to about 1 milligram.

12. A glucose monitoring device, the device comprising:

a glucose sensor comprising;

a working electrode comprising a sensing layer disposed thereon, wherein the sensing layer comprises an analyte responsive enzyme;

a membrane disposed over at least a portion of the sensing layer; and

a counter electrode;

wherein said glucose sensor is capable of providing clinically accurate analyte levels immediately following positioning of at least a portion of the sensor in a patient.

13. The device of claim 12, wherein the sensor comprises an antiglycolytic agent or precursor thereof, wherein the antiglycolytic agent or precursor thereof is glyceraldehyde, mannose, glucosamine, mannoheptulose, sorbose-6-phosphate, or trehalose-6-phosphate.

14. The device of claim 13, wherein the membrane comprises the antiglycolytic agent or precursor thereof.